Developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatography separation of nimodipine and impurities in tablets using experimental design methodology

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 5, 2009, Pages 1192-1202

  Barmpalexis, Panagiotis ^a   Kanaze, Feras Imad ^b   Georgarakis, Emanouil ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Pharmaceutical Industry   (Greece)

Author keywords

Impurities; Multiple response optimization; Nimodipine; Reversed phase HPLC; Statistical experimental design

Indexed keywords

NIMODIPINE;

ARTICLE; DRUG DETERMINATION; DRUG IMPURITY; EXPERIMENTAL DESIGN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TABLET FORMULATION;

CALCIUM CHANNEL BLOCKERS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; NIMODIPINE; PHARMACEUTICAL PREPARATIONS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET; TABLETS; TIME FACTORS;

EID: 67349218443     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.03.003     Document Type: Article

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