Down modulation of IFN-γ signaling in alveolar macrophages isolated from smokers

Toxicology and Applied Pharmacology

Volumn 237, Issue 1, 2009, Pages 22-28

  Dhillon, Navneet K ^a   Murphy, William J ^a   Filla, Michael B ^a   Crespo, Ana J ^b   Latham, Heath A ^a   O'Brien Ladner, Amy ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Cytokine receptors; Inflammation; Monocytes macrophage; Signal transduction; Transcription factor

Indexed keywords

CELL SURFACE RECEPTOR; CIGARETTE SMOKE; CYTOKINE; CYTOKINE RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERFERON REGULATORY FACTOR 1; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MONOCYTE; RECEPTOR DOWN REGULATION; RESPIRATORY TRACT DISEASE; SIGNAL TRANSDUCTION; TOBACCO; WESTERN BLOTTING;

ADULT; CASE-CONTROL STUDIES; DOWN-REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON-GAMMA; MACROPHAGES, ALVEOLAR; RECEPTORS, INTERFERON; REFERENCE VALUES; SIGNAL TRANSDUCTION; SMOKING; STAT1 TRANSCRIPTION FACTOR;

NICOTIANA TABACUM;

EID: 67349194920     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.021     Document Type: Article

References (52)

1. Bach E.A., Aguet M., and Schreiber R.D. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15 (1997) 563-591
2. Ball E.D., Sorenson G.D., and Pettengill O.S. Expression of myeloid and major histocompatibility antigens on small cell carcinoma of the lung cell lines analyzed by cytofluorography: modulation by gamma-interferon. Cancer Res. 46 (1986) 2335-2339
3. Barbers R.G., Gong Jr. H., Tashkin D.P., Oishi J., and Wallace J.M. Differential examination of bronchoalveolar lavage cells in tobacco cigarette and marijuana smokers. Am. Rev. Respir. Dis. 135 (1987) 1271-1275
4. Braun K.M., Cornish T., Valm A., Cundiff J., Pauly J.L., and Fan S. Immunotoxicology of cigarette smoke condensates: suppression of macrophage responsiveness to interferon gamma. Toxicol. Appl. Pharmacol. 149 (1998) 136-143
5. Brown G.P., Iwamoto G.K., Monick M.M., and Hunninghake G.W. Cigarette smoking decreases interleukin 1 release by human alveolar macrophages. Am. J. Physiol. 256 (1989) C260-264
6. Bruder D., Srikiatkhachorn A., and Enelow R.I. Cellular immunity and lung injury in respiratory virus infection. Viral. Immunol. 19 (2006) 147-155
7. Celada A., and Schreiber R.D. Internalization and degradation of receptor-bound interferon-gamma by murine macrophages. Demonstration of receptor recycling. J. Immunol. 139 (1987) 147-153
8. Chesler D.A., and Reiss C.S. The role of IFN-gamma in immune responses to viral infections of the central nervous system. Cytokine Growth Factor Rev. 13 (2002) 441-454
9. Darnell Jr. J.E. Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway. J. Interferon Cytokine Res. 18 (1998) 549-554
10. Edwards K., Braun K.M., Evans G., Sureka A.O., and Fan S. Mainstream and sidestream cigarette smoke condensates suppress macrophage responsiveness to interferon gamma. Hum. Exp. Toxicol. 18 (1999) 233-240
11. Fischer T., Thoma B., Scheurich P., and Pfizenmaier K. Glycosylation of the human interferon-gamma receptor. N-linked carbohydrates contribute to structural heterogeneity and are required for ligand binding. J. Biol. Chem. 265 (1990) 1710-1717
12. Gao J.J., Filla M.B., Fultz M.J., Vogel S.N., Russell S.W., and Murphy W.J. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J. Immunol. 161 (1998) 4803-4810
13. Gattoni A., Parlato A., Vangieri B., Bresciani M., and Derna R. Interferon-gamma: biologic functions and HCV therapy (type I/II) (2 of 2 parts). Clin. Ter. 157 (2006) 457-468
14. Gattoni A., Parlato A., Vangieri B., Bresciani M., and Derna R. Interferon-gamma: biologic functions and HCV therapy (type I/II) (1 of 2 parts). Clin. Ter. 157 (2006) 377-386
15. Ghio A.J., Pritchard R.J., Dittrich K.L., and Samet J.M. Non-heme (Fe3+) in the lung increases with age in both humans and rats. J. Lab. Clin. Med. 129 (1997) 53-61
16. Gifford G.E., and Lohmann-Matthes M.L. Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide. J. Natl. Cancer Inst. 78 (1987) 121-124
17. Greenlund A.C., Farrar M.A., Viviano B.L., and Schreiber R.D. Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). Embo J. 13 (1994) 1591-1600
18. Halme M., Maasilta P., Repo H., Ristola M., Taskinen E., Mattson K., and Cantell K. Inhaled recombinant interferon gamma in patients with lung cancer: pharmacokinetics and effects on chemiluminescence responses of alveolar macrophages and peripheral blood neutrophils and monocytes. Int. J. Radiat. Oncol. Biol. Phys. 31 (1995) 93-101
19. Harris J.O., Swenson E.W., and Johnson III J.E. Human alveolar macrophages: comparison of phagocytic ability, glucose utilization, and ultrastructure in smokers and nonsmokers. J. Clin. Invest. 49 (1970) 2086-2096
20. Hayes M.P., and Zoon K.C. Priming of human monocytes for enhanced lipopolysaccharide responses: expression of alpha interferon, interferon regulatory factors, and tumor necrosis factor. Infect. Immun. 61 (1993) 3222-3227
21. Hong W.S., Jett J.R., Sasaki Y., Takahashi H., Nakano H., Nakagawa K., Hoshi A., and Saijo N. Colony inhibitory effect of recombinant human tumor necrosis factor (rH-TNF) and/or recombinant human interferon (rH-IFN)-alpha, -beta and -gamma on human lung cancer cell lines. Jpn. J. Clin. Oncol. 17 (1987) 49-55
22. HuangFu W.C., Liu J., Harty R.N., and Fuchs S.Y. Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor. FEBS Lett. 582 (2008) 3206-3210
23. Jabbar S.A., and Twentyman P.R. The use of clonogenic assays in assessing the response of human lung cancer cell lines to alpha and gamma interferons alone or in combination with adriamycin. Int. J. Cancer. 46 (1990) 546-551
24. Janoff A., Pryor W.A., and Bengali Z.H. NHLBI workshop summary. Effects of tobacco smoke components on cellular and biochemical processes in the lung. Am. Rev. Respir. Dis. 136 (1987) 1058-1064
25. Jett J.R., Maksymiuk A.W., Su J.Q., Mailliard J.A., Krook J.E., Tschetter L.K., Kardinal C.G., Twito D.I., Levitt R., and Gerstner J.B. Phase III trial of recombinant interferon gamma in complete responders with small-cell lung cancer. J. Clin. Oncol. 12 (1994) 2321-2326
26. Krakauer T., and Oppenheim J.J. IL-1 and tumor necrosis factor-alpha each up-regulate both the expression of IFN-gamma receptors and enhance IFN-gamma-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1). J. Immunol. 150 (1993) 1205-1211
27. Lackmann M., Harpur A.G., Oates A.C., Mann R.J., Gabriel A., Meutermans W., Alewood P.F., Kerr I.M., Stark G.R., and Wilks A.F. Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes. Growth factors (Chur, Switzerland) 16 (1998) 39-51
28. McGowan S.E., and Henley S.A. Iron and ferritin contents and distribution in human alveolar macrophages. J. Lab. Clin. Med. 111 (1988) 611-617
29. Merlin G., van der Leede B.J., McKune K., Knezevic N., Bannwarth W., Romquin N., Viegas-Pequignot E., Kiefer H., Aguet M., and Dembic Z. The gene for the ligand binding chain of the human interferon gamma receptor. Immunogenetics 45 (1997) 413-421
30. Muller M., Briscoe J., Laxton C., Guschin D., Ziemiecki A., Silvennoinen O., Harpur A.G., Barbieri G., Witthuhn B.A., Schindler C., et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366 (1993) 129-135
31. Murray H.W. Interferon-gamma, the activated macrophage, and host defense against microbial challenge. Ann. Intern. Med. 108 (1988) 595-608
32. O'Brien-Ladner A.R., Blumer B.M., and Wesselius L.J. Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron. J. Lab. Clin. Med. 132 (1998) 497-506
33. Prior, C., Thaler, J., and Huber, H. (1998). Comments on Role of recombinant interferon-gamma maintenance in responding patients with small cell lung cancer. A randomised phase III study of the EORTC Lung Cancer Cooperative Group, van Zandwijk et al., Eur J Cancer 1997, 33, 1759-1766. Eur J Cancer 34, 1638.
34. Rahman I., and MacNee W. Role of oxidants/antioxidants in smoking-induced lung diseases. Free Radic. Biol. Med. 21 (1996) 669-681
35. Rhee S., Ebensperger C., Dembic Z., and Pestka S. The structure of the gene for the second chain of the human interferon-gamma receptor. J. Biol. Chem. 271 (1996) 28947-28952
36. Sakatsume M., and Finbloom D.S. Modulation of the expression of the IFN-gamma receptor beta-chain controls responsiveness to IFN-gamma in human peripheral blood T cells. J. Immunol. 156 (1996) 4160-4166
37. Sakatsume M., Igarashi K., Winestock K.D., Garotta G., Larner A.C., and Finbloom D.S. The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. J. Biol. Chem. 270 (1995) 17528-17534
38. Sanceau J., Merlin G., and Wietzerbin J. Tumor necrosis factor-alpha and IL-6 up-regulate IFN-gamma receptor gene expression in human monocytic THP-1 cells by transcriptional and post-transcriptional mechanisms. J. Immunol. 149 (1992) 1671-1675
39. Scheibenbogen C., and Andreesen R. Developmental regulation of the cytokine repertoire in human macrophages: IL-1, IL-6, TNF-alpha, and M-CSF. J. Leukoc. Biol. 50 (1991) 35-42
40. Schiller J.H., Storer B., Dreicer R., Rosenquist D., Frontiera M., and Carbone P.P. Randomized phase II-III trial of combination beta and gamma interferons and etoposide and cisplatin in inoperable non-small cell cancer of the lung. J. Natl. Cancer Inst. 81 (1989) 1739-1743
41. Schindler C., Fu X.Y., Improta T., Aebersold R., and Darnell Jr. J.E. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 7836-7839
42. Shuai K., Ziemiecki A., Wilks A.F., Harpur A.G., Sadowski H.B., Gilman M.Z., and Darnell J.E. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 366 (1993) 580-583
43. Skrenta H., Yang Y., Pestka S., and Fathman C.G. Ligand-independent down-regulation of IFN-gamma receptor 1 following TCR engagement. J. Immunol. 164 (2000) 3506-3511
44. Soliman D.M., and Twigg III H.L. Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages. Am. J. Physiol. 263 (1992) L471-478
45. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., and Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67 (1998) 227-264
46. Starr R., Willson T.A., Viney E.M., Murray L.J., Rayner J.R., Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A., and Hilton D.J. A family of cytokine-inducible inhibitors of signalling. Nature 387 (1997) 917-921
47. Thompson A.B., Bohling T., Heires A., Linder J., and Rennard S.I. Lower respiratory tract iron burden is increased in association with cigarette smoking. J. Lab. Clin. Med. 117 (1991) 493-499
48. van Zandwijk N., Groen H.J., Postmus P.E., Burghouts J.T., ten Velde G.P., Ardizzoni A., Smith I.E., Baas P., Sahmoud T., Kirkpatrick A., Dalesio O., and Giaccone G. Role of recombinant interferon-gamma maintenance in responding patients with small cell lung cancer. A randomised phase III study of the EORTC Lung Cancer Cooperative Group. Eur. J. Cancer. 33 (1997) 1759-1766
49. Williams M.A., Newland A.C., and Kelsey S.M. The potential for monocyte-mediated immunotherapy during infection and malignancy. Part I: apoptosis induction and cytotoxic mechanisms. Leuk. Lymphoma. 34 (1999) 1-23
50. Yamaguchi E., Itoh A., Furuya K., Miyamoto H., Abe S., and Kawakami Y. Release of tumor necrosis factor-alpha from human alveolar macrophages is decreased in smokers. Chest 103 (1993) 479-483
51. Yamaguchi E., Okazaki N., Itoh A., Abe S., Kawakami Y., and Okuyama H. Interleukin 1 production by alveolar macrophages is decreased in smokers. Am. Rev. Respir. Dis. 140 (1989) 397-402
52. Yanagawa H., Haku T., Hiramatsu K., Nokihara H., Takeuchi E., Yano S., Hanibuchi M., and Sone S. Intrapleural instillation of interferon gamma in patients with malignant pleurisy due to lung cancer. Cancer. Immunol. Immunother. 45 (1997) 93-99