Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine model. Electrophysiological and histological characterisation

Experimental Eye Research

Volumn 88, Issue 6, 2009, Pages 1100-1106

  Kyhn, Maria Voss ^a   Warfvinge, Karin ^c,d   Scherfig, Erik ^a,b   Kiilgaard, Jens F ^a   Prause, Jan Ulrik ^b   Klassen, Henry ^e   Young, Michael ^f   la Cour, Morten ^g  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^g Copenhagen University Hospital ^*  (Denmark)

Author keywords

acute glaucoma; anaesthesia; induced components; low perfusion pressure; multifocal ERG; pig; retinal ischemia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CLOSED ANGLE GLAUCOMA; CONTROLLED STUDY; ELECTRORETINOGRAM; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; MEAN ARTERIAL PRESSURE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RETINA AMACRINE CELL; RETINA BLOOD FLOW; RETINA GANGLION CELL; RETINA HORIZONTAL NERVE CELL; RETINA ISCHEMIA; SWINE;

ACUTE DISEASE; AMACRINE CELLS; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; FEMALE; INTRAOCULAR PRESSURE; ISCHEMIA; RETINAL DISEASES; RETINAL GANGLION CELLS; RETINAL HORIZONTAL CELLS; RETINAL VESSELS; SUS SCROFA;

EID: 67349188922     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.01.016     Document Type: Article

References (26)

1. Ball S.L., and Petry H.M. Noninvasive assessment of retinal function in rats using multifocal electroretinography. Investig. Ophthalmol. Vis. Sci. 41 (2000) 610-617
2. Bui B.V., Edmunds B., Cioffi G.A., and Fortune B. The gradient of retinal functional changes during acute intraocular pressure elevation. Investig. Ophthalmol. Vis. Sci. 46 (2005) 202-213
3. Colotto A., Falsini B., Salgarello T., Buzzonetti L., Cermola S., and Porrello G. Transiently raised intraocular pressure reveals pattern electroretinogram losses in ocular hypertension. Investig. Ophthalmol. Vis. Sci. 37 (1996) 2663-2670
4. Fortune B., Cull G., Wang L., Van Buskirk E.M., and Cioffi G.A. Factors affecting the use of multifocal electroretinography to monitor function in a primate model of glaucoma. Doc. Ophthalmol. 105 (2002) 151-178
5. Garca M., Ruiz-Ederra J., Hernandez-Barbachano H., and Vecino E. Topography of pig retinal ganglion cells. J. Comp. Neurol. 486 (2005) 361-372
6. Gerke Jr. C.G., Hao Y., and Wong F. Topography of rods and cones in the retina of the pig. Hong Kong Med. J. 1 (2008) 302-308
7. Gjorloff K.W., Andreasson S., and Ghosh F. mfERG in normal and lesioned rabbit retina. Graefe's Arch. Clin. Exp. Ophthalmol. 244 (2006) 83-89
8. Grozdanic S.D., Matic M., Betts D.M., Sakaguchi D.S., and Kardon R.H. Recovery of canine retina and optic nerve function after acute elevation of intraocular pressure: implications for canine glaucoma treatment. Vet. Ophthalmol. 10 Suppl. 1 (2007) 101-107
9. Grozdanic S.D., Sakaguchi D.S., Kwon Y.H., Kardon R.H., and Sonea I.M. Functional characterization of retina and optic nerve after acute ocular ischemia in rats. Investig. Ophthalmol. Vis. Sci. 44 (2003) 2597-2605
10. Hasegawa S., Takagi M., Usui T., Takada R., and Abe H. Waveform changes of the first-order multifocal electroretinogram in patients with glaucoma. Investig. Ophthalmol. Vis. Sci. 41 (2000) 1597-1603
11. He Z., Bui B.V., and Vingrys A.J. The rate of functional recovery from acute IOP elevation. Investig. Ophthalmol. Vis. Sci. 47 (2006) 4872-4880
12. He Z., Bui B.V., and Vingrys A.J. Effect of repeated IOP challenge on rat retinal function. Investig. Ophthalmol. Vis. Sci. 49 (2008) 3026-3034
13. Hood D.C., Bearse Jr. M.A., Sutter E.E., Viswanathan S., and Frishman L.J. The optic nerve head component of the monkey's (Macaca mulatta) multifocal electroretinogram (mERG). Vision Res. 41 (2001) 2029-2041
14. Hood D.C., Greenstein V., Frishman L., Holopigian K., Viswanathan S., Seiple W., Ahmed J., and Robson J.G. Identifying inner retinal contributions to the human multifocal ERG. Vision Res. 39 (1999) 2285-2291
15. Hood D.C., Bach M., Brigell M., Keating D., Kondo M., Lyons J.S., and Palmowski-Wolfe A.M. ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc. Ophthalmol 116 (2008) 1-11
16. Jehle T., Wingert K., Dimitriu C., Meschede W., Lasseck J., Bach M., and Lagreze W.A. Quantification of ischemic damage in the rat retina: a comparative study using evoked potentials, electroretinography, and histology. Investig. Ophthalmol. Vis. Sci. 49 (2008) 1056-1064
17. Kyhn M.V. Multifocal electroretinography (mfERG) in porcine eyes: establishment, sensitivity and functional implications of induced retinal lesions. Acta Ophthalmol. Scand. Thesis 3, 85 (2007) 1-24
18. Kyhn M.V., Kiilgaard J.F., Scherfig E., Prause J.U., and la C.M. The spatial resolution of the porcine multifocal electroretinogram for detection of laser-induced retinal lesions. Acta Ophthalmol 86 7 (2008) 786-793
19. la Cour M., Kiilgaard J.F., Eysteinsson T., Wiencke A.K., Bang K., Dollerup J., Jensen P.K., and Stefansson E. Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide. Br. J. Ophthalmol. 84 (2000) 1045-1049
20. Lalonde M.R., Chauhan B.C., and Tremblay F. Retinal ganglion cell activity from the multifocal electroretinogram in pig: optic nerve section, anaesthesia and intravitreal tetrodotoxin. J. Physiol. 570 (2006) 325-338
21. Palmowski A.M., Sutter E.E., Bearse Jr. M.A., and Fung W. Mapping of retinal function in diabetic retinopathy using the multifocal electroretinogram. Investig. Ophthalmol. Vis. Sci. 38 (1997) 2586-2596
22. Raz D., Seeliger M.W., Geva A.B., Percicot C.L., Lambrou G.N., and Ofri R. The effect of contrast and luminance on mfERG responses in a monkey model of glaucoma. Investig. Ophthalmol. Vis. Sci. 43 (2002) 2027-2035
23. Shimada Y., Li Y., Bearse Jr. M.A., Sutter E.E., and Fung W. Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br. J. Ophthalmol. 85 (2001) 414-419
24. Stefansson E., Pedersen D.B., Jensen P.K., la Cour M., Kiilgaard J.F., Bang K., and Eysteinsson T. Optic nerve oxygenation. Prog. Retin. Eye Res. 24 (2005) 307-332
25. Sutter E.E., and Tran D. The field topography of ERG components in man-I. The photopic luminance response. Vision Res. 32 (1992) 433-446
26. Voss K.M., Kiilgaard J.F., Lopez A.G., Scherfig E., Prause J.U., and la Cour M. The multifocal electroretinogram (mfERG) in the pig. Acta Ophthalmol. Scand. 85 (2007) 438-444