Effect of Increasing Dialyzer Mass Transfer Area Coefficient and Dialysate Flow on Clearance of Protein-Bound Solutes: A Pilot Crossover Trial

American Journal of Kidney Diseases

Volumn 53, Issue 6, 2009, Pages 1042-1049

  Luo, Frank J G ^a   Patel, Kajal P ^a   Marquez, Ilian O ^a   Plummer, Natalie S ^a   Hostetter, Thomas H ^b   Meyer, Timothy W ^a  

^a STANFORD UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Clearance; hemodialysis; protein bound solutes

Indexed keywords

HIPPURIC ACID; INDICAN; KYNURENIC ACID; NITROGEN; PARA CRESOL; PARA CRESOL SULFATE; PLASMA PROTEIN; UNCLASSIFIED DRUG; UREA;

ARTICLE; ARTIFICIAL KIDNEY; BLOOD FLOW; CLEARANCE; CLINICAL ARTICLE; CONTROLLED STUDY; DIALYSATE; DIALYSIS; HEMODIALYSIS; HUMAN; LONG TERM CARE; PROTEIN BINDING; SOLUTE;

BLOOD UREA NITROGEN; CROSS-OVER STUDIES; DIALYSIS SOLUTIONS; HUMANS; KIDNEY DISEASES; KYNURENIC ACID; METABOLIC CLEARANCE RATE; PILOT PROJECTS; PROTEIN BINDING; PROTEINS; RENAL DIALYSIS;

EID: 67349182892     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.01.265     Document Type: Article

References (20)

1. Vanholder R., De Smet R., and Lameire N. Protein-bound uremic solutes: The forgotten toxins. Kidney Int Suppl 78 (2001) S266-S270
2. Bammens B., Evenepoel P., Verbeke K., and Vanrenterghem Y. Removal of the protein-bound solute p-cresol by convective transport: A randomized crossover study. Am J Kidney Dis 44 (2004) 278-285
3. De Smet R., Dhondt A., Eloot S., Galli F., Waterloos M.A., and Vanholder R. Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes. Nephrol Dial Transplant 22 (2007) 2006-2012
4. Martinez A.W., Recht N.S., Hostetter T.H., and Meyer T.W. Removal of p-cresol sulfate by hemodialysis. J Am Soc Nephrol 16 (2005) 3430-3436
5. Brunet P., Dou L., Cerini C., and Berland Y. Protein-bound uremic retention solutes. Adv Ren Replace Ther 10 (2003) 310-320
6. Meyer T.W., Leeper E.C., Bartlett D.W., et al. Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes. J Am Soc Nephrol 15 (2004) 1927-1935
7. Meyer T.W., Walther J.L., Pagtalunan M.E., et al. The clearance of protein-bound solutes by hemofiltration and hemodiafiltration. Kidney Int 68 (2005) 867-877
8. Mackay G.M., Forrest C.M., Stoy N., et al. Tryptophan metabolism and oxidative stress in patients with chronic brain injury. Eur J Neurol 13 (2006) 30-42
9. Michaels A.S. Operating parameters and performance criteria for hemodialyzers and other membrane-separation devices. Trans Am Soc Artif Intern Organs 12 (1966) 387-392
10. Fagugli R.M., De Smet R., Buoncristiani U., Lameire N., and Vanholder R. Behavior of non-protein-bound and protein-bound uremic solutes during daily hemodialysis. Am J Kidney Dis 40 (2002) 339-347
11. Lesaffer G., De Smet R., Lameire N., Dhondt A., Duym P., and Vanholder R. Intradialytic removal of protein-bound uraemic toxins: Role of solute characteristics and of dialyser membrane. Nephrol Dial Transplant 15 (2000) 50-57
12. Langsdorf L.J., Krankel L.G., and Zydney A.L. Effect of blood-membrane interactions on solute clearance during hemodialysis. ASAIO J 39 (1993) M767-M772
13. 0A and true blood flow determined from a model of cross-dialyzer urea extraction. ASAIO J 50 (2004) 85-93
14. Eloot S., Torremans A., De Smet R., et al. Complex compartmental behavior of small water-soluble uremic retention solutes: Evaluation by direct measurements in plasma and erythrocytes. Am J Kidney Dis 50 (2007) 279-288
15. Meijers B.K., Weber V., Bammens B., et al. Removal of the uremic retention solute p-cresol using fractionated plasma separation and adsorption. Artif Organs 32 (2008) 214-219
16. De Smet R., Van Kaer J., Van Vlem B., et al. Toxicity of free p-cresol: A prospective and cross-sectional analysis. Clin Chem 49 (2003) 470-478
17. Bammens B., Evenepoel P., Keuleers H., Verbeke K., and Vanrenterghem Y. Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int 69 (2006) 1081-1087
18. Schepers E., Meert N., Glorieux G., Goeman J., Van der Eycken J., and Vanholder R. p-Cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production. Nephrol Dial Transplant 22 (2007) 592-596
19. Dou L., Jourde-Chiche N., Faure V., et al. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J Thromb Haemost 5 (2007) 1302-1308
20. Taki K., Tsuruta Y., and Niwa T. Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients. Am J Nephrol 27 (2007) 30-35