Elevated plasma chromogranin a is the first indication of recurrence in radically operated midgut carcinoid tumors

Neuroendocrinology

Volumn 89, Issue 3, 2009, Pages 302-307

  Welin, Staffan ^a   Stridsberg, Mats ^a   Cunningham, Janet ^a   Granberg, Dan ^a   Skogseid, Britt ^a   Öberg, Kjell ^a   Eriksson, Barbro ^a   Janson, Eva T ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chromogranin A; Midgut carcinoid tumor; Tumor recurrences

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 5 HYDROXYTRYPTOPHAN; CHROMOGRANIN A; SOMATOSTATIN RECEPTOR;

ADULT; AGED; ARTICLE; CANCER SURGERY; CARCINOID; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ECHOGRAPHY; FEMALE; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MIDGUT; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCINTIGRAPHY; TUMOR RECURRENCE; URINE LEVEL;

5-HYDROXYTRYPTOPHAN; ADULT; AGED; AGED, 80 AND OVER; CARCINOID TUMOR; CHROMOGRANIN A; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, SOMATOSTATIN; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MARKERS, BIOLOGICAL; ULTRASONOGRAPHY;

EID: 67349181854     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000179900     Document Type: Article

References (18)

1. Janson ET, Holmberg L, Stridsberg M, Eriksson B, Theodorsson E, Wilander E, Oberg K: Carcinoid tumors: analysis of prognostic factors and survival in 301 patients from a referral center. Ann Oncol 1997; 8: 685-690.
2. Oberg K: The ultimate biochemical diagnosis of gastro-enteropancreatic tumours. Digestion 1996; 57(suppl 1):45-47.
3. Grahame-Smith DG, Peart WS, Ferriman DG: Carcinoid syndrome. Proc R Soc Med 1965; 58: 701-702.
4. Akerstrom G, Hellman P, Hessman O, Osmak L: Management of midgut carcinoids. J Surg Oncol 2005; 89: 161-169.
5. Moertel CG: Karnofsky Memorial Lecture. An odyssey in the land of small tumors. J Clin Oncol 1987; 5: 1502-1522.
6. Wangberg B, Westberg G, Tylen U, Tisell L, Jansson S, Nilsson O, Johansson V, Schersten T, Ahlman H: Survival of patients with disseminated midgut carcinoid tumors after aggressive tumor reduction. World J Surg 1996; 20: 892-899.
7. Doherty GM, Olson JA, Frisella MM, Lairmore TC, Wells SA Jr, Norton JA: Lethality of multiple endocrine neoplasia type I. World J Surg 1998; 22: 581-587.
8. Norton JA, Fraker DL, Alexander HR, Gibril F, Liewehr DJ, Venzon DJ, Jensen RT: Surgery increases survival in patients with gastrinoma. Ann Surg 2006; 244: 410-419.
9. Stridsberg M, Hellman U, Wilander E, Lundqvist G, Hellsing K, Oberg K: Fragments of chromogranin A are present in the urine of patients with carcinoid tumours: development of a specific radioimmunoassay for chromogranin A and its fragments. J Endocrinol 1993; 139: 329-337.
10. Granberg D, Stridsberg M, Seensalu R, Eriksson B, Lundqvist G, Oberg K, Skogseid B: Plasma chromogranin A in patients with multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 1999; 84: 2712-2717.
11. Stridsberg M, Eriksson B, Oberg K, Janson ET: A comparison between three commercial kits for chromogranin A measurements. J Endocrinol 2003; 177: 337-341.
12. Kolby L, Bernhardt P, Sward C, Johanson V, Ahlman H, Forssell-Aronsson E, Stridsberg M, Wangberg B, Nilsson O: Chromogranin A as a determinant of midgut carcinoid tumour volume. Regul Pept 2004; 120: 269-273.
13. Eriksson B, Oberg K: Peptide hormones as tumor markers in neuroendocrine gastrointestinal tumors. Acta Oncol 1991; 30: 477-483.
14. Pirker RA, Pont J, Pohnl R, Schutz W, Griesmacher A, Muller MM: Usefulness of chromogranin A as a marker for detection of relapses of carcinoid tumours. Clin Chem Lab Med 1998; 36: 837-840.
15. Hsiao RJ, Mezger MS, O'Connor DT: Chromogranin A in uremia: progressive retention of immunoreactive fragments. Kidney Int 1990; 37: 955-964.
16. Borch K, Stridsberg M, Burman P, Rehfeld JF: Basal chromogranin A and gastrin concentrations in circulation correlate to endocrine cell proliferation in type-A gastritis. Scand J Gastroenterol 1997; 32: 198-202.
17. Sanduleanu S, Stridsberg M, Jonkers D, Hameeteman W, Biemond I, Lundqvist G, Lamers C, Stockbrugger RW: Serum gastrin and chromogranin A during medium- and longterm acid suppressive therapy: a case-control study. Aliment Pharmacol Ther 1999; 13: 145-153.
18. Orlefors H, Sundin A, Garske U, Juhlin C, Oberg K, Skogseid B, Langstrom B, Bergstrom M, Eriksson B: Whole-body 11 C-5-hydroxytryptophan positron emission tomography as a universal imaging technique for neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and computed tomography. J Clin Endocrinol Metab 2005; 90: 3392-3400.