Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: A case report

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 1, 2009, Pages 177-181

  Bharthuar, Anubha ^a   Egloff, Lori ^a   Becker, Joanne ^a   George, Marina ^a   Lohr, James W ^a   Deeb, George ^a   Iyer, Renuka V ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Chemotherapy; Gemcitabine; HUS; Pancreatic cancer; Rituximab

Indexed keywords

ANTIHYPERTENSIVE AGENT; BEVACIZUMAB; CAPECITABINE; CREATININE; DEXAMETHASONE; DIURETIC AGENT; FUROSEMIDE; GEMCITABINE; LABETALOL; METHYLPREDNISOLONE; PHENYTOIN; RITUXIMAB; VINCRISTINE;

ABDOMINAL SWELLING; ADULT; ARTICLE; BLOOD SMEAR; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CASE REPORT; CLINICAL FEATURE; CONGESTIVE HEART FAILURE; CREATININE BLOOD LEVEL; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FACE EDEMA; FEMALE; FLUID RETENTION; GRAND MAL EPILEPSY; HEMATOLOGICAL PARAMETERS; HEMODIALYSIS; HEMOLYTIC UREMIC SYNDROME; HUMAN; HYPERTENSION; KIDNEY FAILURE; LIFE EXPECTANCY; METASTASIS; METASTATIC PANCREATIC ADENOCARCINOMA; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; NEPHROTIC SYNDROME; NEUTROPENIA; OUTCOME ASSESSMENT; PANCREAS ADENOCARCINOMA; PERIPHERAL EDEMA; PLASMAPHERESIS; PLEURA EFFUSION; PRIORITY JOURNAL; PROTEINURIA; RETROSPECTIVE STUDY; SIDE EFFECT; SURVIVAL; THROMBOCYTOPENIA;

ADENOCARCINOMA; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; FEMALE; GLUCOCORTICOIDS; HEMOLYTIC-UREMIC SYNDROME; HUMANS; IMMUNOLOGIC FACTORS; MIDDLE AGED; PANCREATIC NEOPLASMS; PLASMAPHERESIS; RETROSPECTIVE STUDIES; VINCRISTINE;

EID: 67349159820     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0900-x     Document Type: Article

References (25)

1. ES Casper MR Green DP Kelsen 1994 Phase II trial of gemcitabine (2, 2′-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas Invest New Drugs 12 29 34 (Pubitemid 24209062)
2. MC Fung AM Storniolo B Nguyen M Arning W Brookfield J Vigil 1999 A review of hemolytic uremic syndrome in patients treated with gemcitabine therapy Cancer 85 2023 2032 (Pubitemid 29202779)
3. J Desrame C Duvic C Bredin 2005 Hemolytic uremic syndrome as a complication of gemcitabine treatment: report of six cases and review of the literature Rev Med Interne 26 179 188 (Pubitemid 40500883)
4. M Gross C Hiesse F Kriaa F Goldwasser 1999 Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine Anticancer Drugs 10 533 536 (Pubitemid 29410799)
5. L Teixeira P Debourdeau C Zammit JL Estival M Pavic B Colle 2002 Gemcitabine-induced thrombotic microangiopathy Presse Med 31 740 742 (Pubitemid 34475173)
6. T Brodowicz S Breiteneder C Wiltschke CC Zielinski 1997 Gemcitabine-induced hemolytic uremic syndrome: a case report J Natl Cancer Inst 89 1895 1896 (Pubitemid 28009827)
7. K Lhotta T Kuhr HJ Rumpelt E Woll J Thaler P Konig 1999 Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy Am J Nephrol 19 590 593
8. L Venat-Bouvet K Ly JC Szelag 2003 Thrombotic microangiopathy and digital necrosis: two unrecognized toxicities of gemcitabine Anticancer Drugs 14 829 832 (Pubitemid 38339788)
9. GA Hosler AM Cusumano GM Hutchins 2003 Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases Arch Pathol Lab Med 127 834 839 (Pubitemid 36792310)
10. P Ruggenenti M Noris G Remuzzi 2001 Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura Kidney Int 60 831 846 (Pubitemid 34205784)
11. H von Baeyer 2002 Plasmapheresis in thrombotic microangiopathy-associated syndromes: review of outcome data derived from clinical trials and open studies Ther Apher 6 320 328 (Pubitemid 34184548)
12. M Furlan R Robles M Galbusera 1998 von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome N Engl J Med 339 1578 1584 (Pubitemid 28536132)
13. SK Yassa G Blessios G Marinides RC Venuto 2005 Anti-CD20 monoclonal antibody (Rituximab) for life-threatening hemolytic-uremic syndrome Clin Transpl 19 423 426 (Pubitemid 40711981)
14. M Ostronoff F Ostronoff R Calixto 2007 Life-threatening hemolytic-uremic syndrome treated with rituximab in an allogeneic bone marrow transplant recipient Bone Marrow Transplant 39 649 651 (Pubitemid 46722846)
15. F Fakhouri L Teixeira R Delarue JP Grunfeld A Veyradier 2004 Responsiveness of thrombotic thrombocytopenic purpura to rituximab and cyclophosphamide Ann Intern Med 140 314 315 (Pubitemid 38200541)
16. M Galbusera E Bresin M Noris 2005 Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report Blood 106 925 928 (Pubitemid 41076435)
17. H Kaneko M Matsumoto K Okamoto 2007 Refractory thrombotic thrombocytopenic purpura successfully treated with a combination of rituximab and vincristine Rinsho Ketsueki 48 144 147
18. F Fakhouri JP Vernant A Veyradier 2005 Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases Blood 106 1932 1937 (Pubitemid 41291703)
19. P Therasse SG Arbuck EA Eisenhauer 2000 New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 205 216
20. H Burris AM Storniolo 1997 Assessing clinical benefit in the treatment of pancreas cancer: gemcitabine compared to 5-fluorouracil Eur J Cancer 331 Suppl 1 S18 S22 (Pubitemid 27117676)
21. JL Moake CK Rudy JH Troll 1982 Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura N Engl J Med 307 1432 1435 (Pubitemid 13234018)
22. HW Snyder Jr A Mittelman A Oral 1993 Treatment of cancer chemotherapy-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome by protein A immunoadsorption of plasma Cancer 71 1882 1892 (Pubitemid 23067409)
23. M Bohm C Betz W Miesbach 2005 The course of ADAMTS-13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine Br J Haematol 129 644 652 (Pubitemid 40825826)
24. NT O'Connor P Bruce-Jones LF Hill 1992 Vincristine therapy for thrombotic thrombocytopenic purpura Am J Hematol 39 234 236
25. HA Burris 3rd MJ Moore J Andersen 1997 Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 2403 2413 (Pubitemid 27251144)