Cerebral metabolic rate of oxygen (CMRO2) in pig brain determined by PET after resuscitation from cardiac arrest

Resuscitation

Volumn 80, Issue 6, 2009, Pages 701-706

  Mörtberg, Erik ^a   Cumming, Paul ^b   Wiklund, Lars ^a   Rubertsson, Sten ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cardiopulmonary resuscitation; Cerebral blood flow; Cerebral oxygen metabolism; Positron emission tomography

Indexed keywords

OXYGEN; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; HEART ARREST; HEART VENTRICLE FIBRILLATION; ISCHEMIA; METABOLIC RATE; NONHUMAN; PERFUSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RESUSCITATION; SWINE;

ANIMALS; BRAIN; CARDIOPULMONARY RESUSCITATION; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; HEART ARREST; OXYGEN; OXYGEN CONSUMPTION; POSITRON-EMISSION TOMOGRAPHY; SWINE;

EID: 67349148571     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2009.03.005     Document Type: Article

References (41)

1. Westal R.E., Reissman S., and Doering G. Out-of-hospital cardiac arrests: an 8-year New York City experience. Am J Emerg Med 14 (1996) 364-368
2. Nolan J.P., Neumar R.W., Adrie C., et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation 79 (2008) 350-379
3. Mortberg E., Cumming P., Wiklund L., Wall A., and Rubertsson S. A PET study of regional cerebral blood flow after experimental cardiopulmonary resuscitation. Resuscitation 75 (2007) 98-104
4. Fischer M., and Hossmann K.A. No-reflow after cardiac arrest. Intens Care Med 21 (1995) 132-141
5. Hossmann K.A., Fischer M., Bockhorst K., and Hoehn-Berlage M. NMR imaging of the apparent diffusion coefficient (ADC) for the evaluation of metabolic suppression and recovery after prolonged cerebral ischemia. J Cereb Blood Flow Metab 14 (1994) 723-731
6. Nozari A., Rubertsson S., Gedeborg R., Nordgren A., and Wiklund L. Maximisation of cerebral blood flow during experimental cardiopulmonary resuscitation does not ameliorate post-resuscitation hypoperfusion. Resuscitation 40 (1999) 27-35
7. Gedeborg R., Silander H.C., Rubertsson S., and Wiklund L. Cerebral ischaemia in experimental cardiopulmonary resuscitation-comparison of epinephrine and aortic occlusion. Resuscitation 50 (2001) 319-329
8. Gervais H.W., Schleien C.L., Koehler R.C., Berkowitz I.D., Shaffner D.H., and Traystman R.J. Effect of adrenergic drugs on cerebral blood flow, metabolism, and evoked potentials after delayed cardiopulmonary resuscitation in dogs. Stroke 22 (1991) 1554-1561
9. Kirsch J.R., Helfaer M.A., Blizzard K., Toung T.J., and Traystman R.J. Age-related cerebrovascular response to global ischemia in pigs. Am J Physiol 259 (1990) H1551-H1558
10. Sterz F., Leonov Y., Safar P., et al. Multifocal cerebral blood flow by Xe-CT and global cerebral metabolism after prolonged cardiac arrest in dogs. Reperfusion with open-chest CPR or cardiopulmonary bypass. Resuscitation 24 (1992) 27-47
11. Chien J.C., Jeng M.J., Chang H.L., et al. Cerebral oxygenation during hypoxia and resuscitation by using near-infrared spectroscopy in newborn piglets. J Chin Med Assoc 70 (2007) 47-55
12. Bein B., Cavus E., Stadlbauer K.H., et al. Monitoring of cerebral oxygenation with near infrared spectroscopy and tissue oxygen partial pressure during cardiopulmonary resuscitation in pigs. Eur J Anaesthesiol 23 (2006) 501-509
13. Gopinath S.P., Valadka A.B., Uzura M., and Robertson C.S. Comparison of jugular venous oxygen saturation and brain tissue Po2 as monitors of cerebral ischemia after head injury. Crit Care Med 27 (1999) 2337-2345
14. Schaafsma A., de Jong B.M., Bams J.L., Haaxma-Reiche H., Pruim J., and Zijlstra J.G. Cerebral perfusion and metabolism in resuscitated patients with severe post-hypoxic encephalopathy. J Neurol Sci 210 (2003) 23-30
15. Edgren E., Enblad P., Grenvik A., et al. Cerebral blood flow and metabolism after cardiopulmonary resuscitation. A pathophysiologic and prognostic positron emission tomography pilot study. Resuscitation 57 (2003) 161-170
16. Frykholm P., Andersson J.L., Valtysson J., et al. A metabolic threshold of irreversible ischemia demonstrated by PET in a middle cerebral artery occlusion-reperfusion primate model. Acta Neurol Scand 102 (2000) 18-26
17. Sakoh M., Ostergaard L., Rohl L., et al. Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequential multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 h after stroke in pigs. J Neurosurg 93 (2000) 647-657
18. Steen S., Liao Q., Pierre L., Paskevicius A., and Sjoberg T. Evaluation of LUCAS, a new device for automatic mechanical compression and active decompression resuscitation. Resuscitation 55 (2002) 285-299
19. Herscovitch P., Markham J., and Raichle M.E. Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis. J Nucl Med 24 (1983) 782-789
20. Raichle M.E., Martin W.R., Herscovitch P., Mintun M.A., and Markham J. Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation. J Nucl Med 24 (1983) 790-798
21. Frackowiak R.S., Lenzi G.L., Jones T., and Heather J.D. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomo 4 (1980) 727-736
22. Lammertsma A.A., Baron J.C., and Jones T. Correction for intravascular activity in the oxygen-15 steady-state technique is independent of the regional hematocrit. J Cereb Blood Flow Metab 7 (1987) 372-374
23. Lammertsma A.A., and Jones T. Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain. 1. Description of the method. J Cereb Blood Flow Metab 3 (1983) 416-424
24. Martin W.R., Powers W.J., and Raichle M.E. Cerebral blood volume measured with inhaled C15O and positron emission tomography. J Cereb Blood Flow Metab 7 (1987) 421-426
25. Watanabe H., Andersen F., Simonsen C.Z., Evans S.M., Gjedde A., and Cumming P. MR-based statistical atlas of the Gottingen minipig brain. Neuroimage 14 (2001) 1089-1096
26. Program for Registration of Images (REGISTER). Montreal, Canada: McConnell Brain Imaging Center, Montreal Neurological Institute; 1996.
27. Johansson J., Gedeborg R., Basu S., and Rubertsson S. Increased cortical cerebral blood flow by continuous infusion of adrenaline (epinephrine) during experimental cardiopulmonary resuscitation. Resuscitation 57 (2003) 299-307
28. Nozari A., Rubertsson S., and Wiklund L. Differences in the pharmacodynamics of epinephrine and vasopressin during and after experimental cardiopulmonary resuscitation. Resuscitation 49 (2001) 59-72
29. Beckstead J.E., Tweed W.A., Lee J., and MacKeen W.L. Cerebral blood flow and metabolism in man following cardiac arrest. Stroke 9 (1978) 569-573
30. Geraghty M.C., and Torbey M.T. Neuroimaging and serologic markers of neurologic injury after cardiac arrest. Neurol Clin 24 (2006) 107-121 vii
31. Martin L.J., Brambrink A., Koehler R.C., and Traystman R.J. Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. J Comp Neurol 377 (1997) 262-285
32. Siesjo B.K., and Siesjo P. Mechanisms of secondary brain injury. Eur J Anaesthesiol 13 (1996) 247-268
33. Kirino T., and Sano K. Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol 62 (1984) 201-208
34. Liachenko S., Tang P., Hamilton R.L., and Xu Y. Regional dependence of cerebral reperfusion after circulatory arrest in rats. J Cereb Blood Flow Metab 21 (2001) 1320-1329
35. Krep H., Breil M., Sinn D., Hagendorff A., Hoeft A., and Fischer M. Effects of hypertonic versus isotonic infusion therapy on regional cerebral blood flow after experimental cardiac arrest cardiopulmonary resuscitation in pigs. Resuscitation 63 (2004) 73-83
36. Xu Y., Liachenko S., and Tang P. Dependence of early cerebral reperfusion and long-term outcome on resuscitation efficiency after cardiac arrest in rats. Stroke 33 (2002) 837-843
37. Pantano P., Baron J.C., Samson Y., Bousser M.G., Derouesne C., and Comar D. Crossed cerebellar diaschisis. Further studies. Brain 109 (1986) 677-694 Pt 4
38. Gold L., and Lauritzen M. Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proc Natl Acad Sci USA 99 (2002) 7699-7704
39. Ristagno G., Sun S., Tang W., Castillo C., and Weil M.H. Effects of epinephrine and vasopressin on cerebral microcirculatory flows during and after cardiopulmonary resuscitation. Crit Care Med 35 (2007) 2145-2149
40. Hayashi Y., Hiraide A., Morita H., et al. Three year longitudinal study for out-of-hospital cardiac arrest in Osaka Prefecture. Resuscitation 63 (2004) 161-166
41. Finn J.C., Jacobs I.G., Holman C.D., and Oxer H.F. Outcomes of out-of-hospital cardiac arrest patients in Perth, Western Australia, 1996-1999. Resuscitation 51 (2001) 247-255