Complement upregulation in photodynamic therapy-treated tumors: Role of Toll-like receptor pathway and NFκB

Cancer Letters

Volumn 281, Issue 2, 2009, Pages 232-238

  Korbelik, Mladen ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

Complement system; Mouse SCCVII tumor cells; NF B; Photodynamic therapy; Toll like receptors 2 and 4; Tumor associated macrophages

Indexed keywords

HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOTOFRIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; COMPLEMENT SYSTEM; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HEAD AND NECK CARCINOMA; INNATE IMMUNITY; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MODEL; UPREGULATION;

ANIMALS; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; DIHEMATOPORPHYRIN ETHER; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; NEOPLASMS, EXPERIMENTAL; NF-KAPPA B; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 67349144676     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.02.049     Document Type: Article

References (38)

1. Dougherty T.J., Gomer C.J., Henderson B.W., Jori G., Kessel D., Korbelik M., Moan J., and Peng Q. Photodynamic therapy. J. Natl. Cancer Inst. 90 (1998) 889-905
2. Huang Z. A review of progress in clinical photodynamic therapy. Technol. Cancer Res. Treat. 4 (2005) 283-294
3. Henderson B.W., and Dougherty T.J. How does photodynamic therapy work?. Photochem. Photobiol. 55 (1992) 145-157
4. Korbelik M., and Cecic I. Mechanism of tumor destruction by photodynamic therapy. Handbook of Photochemistry and Photobiology. In: Nalwa H.S. (Ed). Photobiology vol. 4 (2003), American Scientific Publishers, Stevenson Ranch, CA, USA 39-77
5. Korbelik M. PDT-associated host response and its role in the therapy outcome. Lasers Surg. Med. 38 (2006) 500-508
6. Castano A.P., Mroz P., and Hamblin M.R. Photodynamic therapy and anti-tumor immunity. Nat. Rev. Cancer 6 (2006) 535-545
7. Walport M.J. Complement. New Engl. J. Med. 344 (2001) 1058-1066 1140-1144
8. Cecic I., and Korbelik M. Mediators of peripheral blood neutrophilia induced by photodynamic therapy of solid tumors. Cancer Lett. 183 (2002) 43-51
9. Cecic I., Serrano K., Gyongyossy-Issa M., and Korbelik M. Characteristics of complement activation in mice bearing Lewis lung carcinomas treated by photodynamic therapy. Cancer Lett. 225 (2005) 215-223
10. Cecic I., and Korbelik M. Deposition of complement proteins on cells treated by photodynamic therapy in vitro. J. Environ. Pathol. Toxicol. Oncol. 25 (2006) 189-203
11. Cecic I., Sun J., and Korbelik M. Role of complement anaphylatoxin C3a in photodynamic therapy-elicited engagement of neutrophils and other immune cells. Photochem. Photobiol. 82 (2006) 558-562
12. Cecic I., Minchinton A.I., and Korbelik M. The impact of complement activation on tumor oxygenation during photodynamic therapy. Photochem. Photobiol. 83 (2007) 1049-1055
13. Hawlisch H., and Köhl J. Complement and Toll-like receptors: key regulators of adaptive immune responses. Mol. Immunol. 43 (2006) 13-21
14. Zhang X., Kimura Y., Fang C., Zhou L., Sfyroera G., Lambris J.D., Wetsel R.A., Miwa T., and Song W.C. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110 (2007) 228-236
15. Ip W.K., Takahashi K., Moore K.J., Stuart L.M., and Ezekowitz R.A. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J. Exp. Med. 205 (2008) 169-181
16. Stott B., and Korbelik M. Activation of complement C3, C5, and C9 genes in tumors treated by photodynamic therapy. Cancer Immunol. Immunother. 56 (2007) 649-658
17. Korbelik M. PDT and inflammation. In: Hamblin M.R., and Mroz P. (Eds). Advances in Photodynamic Therapy: Basic, Translational, and Clinical (2008), Artech House, Boston 255-266
18. Suit H.D., Sedlacek R.S., Silver G., and Dosoretz D. Phenobarbital anaesthesia and response of tumor and normal tissue in the C3Hf/Sed mouse to radiation. Radiat. Res. 104 (1985) 47-65
19. Khurana D., Martin E.A., Kasperbauer J.L., O'Malley Jr. B.W., Salomao D.R., Chen L., and Strome S.E. Characterization of spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy. Head Neck 23 (2001) 899-906
20. Korbelik M., Krosl G., Olive P.L., and Chaplin D.J. Distribution of Photofrin between tumour cells and tumour associated macrophages. Br. J. Cancer 64 (1991) 508-512
21. Korbelik M. Distribution of disulfonated and tetrasulfonated aluminium phthalocyanine between malignant and host cell populations of a murine fibrosarcoma. Photochem. Photobiol. B: Biol. 20 (1993) 173-181
22. Korbelik M., Sun J., and Cecic I. Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response. Cancer Res. 65 (2005) 1018-1026
23. Cecic I., Stott B., and Korbelik M. Acute phase response-associated systemic neutrophil mobilization in mice bearing tumors treated by photodynamic therapy. Int. Immunopharmacol. 6 (2006) 1259-1266
24. Paterson H.M., Murphy T.J., Purcell E.J., Shelley O., Kriynovich S.J., Lien E., Mannick J.A., and Lederer J.A. Injury primes the innate immune system for enhanced Toll-like receptor activity. J. Immunol. 171 (2003) 1473-1483
25. Matroule J.-Y., Volanti C., and Piette J. NF-B in photodynamic therapy: discrepancies of a master regulator. Photochem. Photobiol. 82 (2006) 1241-1246
26. Korbelik M. Role of Toll-like receptors in photodynamic therapy-elicited host response. Proc. SPIE 5319 (2004) 87-95
27. Beg A.A. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 23 (2002) 509-512
28. Maison C.M., Villiers C.L., and Colomb M.G. Secretion, cleavage and binding of complement component C3 by the human monocytic cell line U937. Biochem J. 261 (1989) 407-413
29. Erdei A., Köhler V., Schäfer H., and Burger R. Macrophage-bound C3 fragments as adhesion molecules modulate presentation of exogenous antigens. Immunobiol. 185 (1992) 314-326
30. Kerekes K., Cooper P.D., Prechl J., Joszi M., Bajtay Z., and Erdei A. Adjuvant effect of-inulin is mediated by C3 fragments deposited on antigen-presenting cells. J. Leukoc. Biol. 69 (2001) 69-74
31. Korbelik M., and Krosl G. Enhanced macrophage cytotoxicity against tumor cells treated with photodynamic therapy. Photochem. Photobiol. 60 (1994) 497-502
32. Asprodites N., Zheng L., Geng D., Velasco-Gonzales C., Sanchez-Perez L., and Davila E. Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J. 22 (2008) 3628-3637
33. Carroll M.C. The complement system in regulation of adaptive immunity. Nat. Immunol. 5 (2004) 981-986
34. Morgan B.P., Marchbank K.J., Longhi M.P., Harris C.L., and Gallimore A.M. Complement: central to innate immunity and bridging to adaptive responses. Immunol. Lett. 97 (2005) 171-179
35. Kemper C., and Atkinson J.P. T-cell regulation: with complements from innate immunity. Nat. Rev. Immunol. 7 (2007) 9-18
36. Korbelik M., Sun J., Cecic I., and Serrano K. Adjuvant treatment for complement activation increases the effectiveness of photodynamic therapy of solid tumors. Photochem. Photobiol. Sci. 3 (2004) 812-816
37. Korbelik M., and Cooper P.D. Potentiation of photodynamic therapy of cancer by complement: the effect of-inulin. Br. J. Cancer 96 (2007) 67-72
38. Korbelik M., and Cecic I. Complement activation cascade and its regulation: relevance for the response of solid tumors to photodynamic therapy. J. Photochem. Photobiol. B: Biol. 93 (2008) 53-59