Molecular mechanism of SugR-mediated sugar-dependent expression of the ldhA gene encoding l-lactate dehydrogenase in Corynebacterium glutamicum

Applied Microbiology and Biotechnology

Volumn 83, Issue 2, 2009, Pages 315-327

  Toyoda, Koichi ^a   Teramoto, Haruhiko ^a   Inui, Masayuki ^a   Yukawa, Hideaki ^a  

^a RESEARCH INSTITUTE OF INNOVATIVE TECHNOLOGY FOR THE EARTH   (Japan)

Author keywords

Corynebacterium glutamicum; Lactate dehydrogenase; Transcriptional regulation

Indexed keywords

CORYNEBACTERIUM GLUTAMICUM; DE REPRESSIONS; DNA AFFINITIES; ELECTROPHORETIC MOBILITY SHIFT ASSAYS; EXPRESSION LEVELS; FOOTPRINT ANALYSIS; IN-VITRO; L LACTATES; LACTATE DEHYDROGENASE; MOLECULAR MECHANISMS; MUTANT CELLS; PROMOTER ACTIVITIES; PROMOTER REGIONS; PROTEIN BINDINGS; REPRESSOR ACTIVITIES; START POINTS; TRANSCRIPTIONAL REGULATION; WILD-TYPE CELLS;

BIOCHEMISTRY; CELL MEMBRANES; ELECTROPHORETIC MOBILITY; ENCODING (SYMBOLS); ENZYMES; FRUCTOSE; GLUCOSE; NUCLEIC ACIDS; SUGAR (SUCROSE); TRANSCRIPTION;

GENE ENCODING;

DEOXYRIBONUCLEASE; DNA; FRUCTOSE; FRUCTOSE 1 PHOSPHATE; GLUCOSE; LACTATE DEHYDROGENASE; PROTEIN; SUGAR;

BACTERIUM; CELL ORGANELLE; DNA; ENZYME; GENE EXPRESSION; GROWTH; MOLECULAR ANALYSIS; SUGAR;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BINDING AFFINITY; BINDING ASSAY; CELL MUTANT; CORYNEBACTERIUM GLUTAMICUM; DNA PURIFICATION; ELECTROPHORETIC MOBILITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLYCOLYSIS; IN VITRO STUDY; LDHA GENE; MOLECULAR MECHANICS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN BINDING; REPRESSOR GENE; SUGAR TRANSPORT; SUGR GENE; TRANSCRIPTION REGULATION; WILD TYPE;

BACTERIAL PROTEINS; CORYNEBACTERIUM GLUTAMICUM; GENE EXPRESSION REGULATION, BACTERIAL; HEXOSES; L-LACTATE DEHYDROGENASE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; UP-REGULATION;

CORYNEBACTERIUM GLUTAMICUM;

EID: 67349140941     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-1887-x     Document Type: Article

References (39)

1. N Asanuma T Yoshii T Hino 2004 Molecular characterization of CcpA and involvement of this protein in transcriptional regulation of lactate dehydrogenase and pyruvate formate-lyase in the ruminal bacterium Streptococcus bovis Appl Environ Microbiol 70 5244 5251 (Pubitemid 39279596)
2. + redox poise in Streptomyces coelicolor A3(2) EMBO J 22 4856 4865 (Pubitemid 37162921)
3. PK Bunch F Mat-Jan N Lee DP Clark 1997 The ldhA gene encoding the fermentative lactate dehydrogenase of Escherichia coli Microbiology 143 187 195 (Pubitemid 27072974)
4. DP Clark 1989 The fermentation pathways of Escherichia coli FEMS Microbiol Rev 63 223 234
5. H Cruz Ramos T Hoffmann M Marino H Nedjari E Presecan-Siedel O Dreesen P Glaser D Jahn 2000 Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression J Bacteriol 182 3072 3080 (Pubitemid 30326920)
6. H Dominguez ND Lindley 1996 Complete sucrose metabolism requires fructose phosphotransferase activity in Corynebacterium glutamicum to ensure phosphorylation of liberated fructose Appl Environ Microbiol 62 3878 3880 (Pubitemid 26329628)
7. H Dominguez C Rollin A Guyonvarch JL Guerquin-Kern M Cocaign-Bousquet ND Lindley 1998 Carbon-flux distribution in the central metabolic pathways of Corynebacterium glutamicum during growth on fructose Eur J Biochem 254 96 102 (Pubitemid 28255074)
8. V Engels VF Wendisch 2007 The DeoR-Type regulator SugR represses expression of ptsG in Corynebacterium glutamicum J Bacteriol 189 2955 2966 (Pubitemid 46697384)
9. V Engels S Lindner VF Wendisch 2008 The global repressor SugR controls expression of genes of glycolysis and of the l-lactate dehydrogenase LdhA in Corynebacterium glutamicum J Bacteriol 190 8033 8044
10. L Gaigalat JP Schlueter M Hartmann S Mormann A Tauch A Pühler J Kalinowski 2007 The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum BMC Mol Biol 8 104
11. T Georgi V Engels VF Wendisch 2008 Regulation of l-lactate utilization by the FadR-type regulator LldR of Corynebacterium glutamicum J Bacteriol 190 963 971
12. T Hermann 2003 Industrial production of amino acids by coryneform bacteria J Biotechnol 104 155 172 (Pubitemid 37011355)
13. M Inui S Murakami S Okino H Kawaguchi AA Vertès H Yukawa 2004 Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions J Mol Microbiol Biotechnol 7 182 196 (Pubitemid 39294707)
14. M Inui M Suda S Okino H Nonaka LG Puskás AA Vertès H Yukawa 2007 Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions Microbiology 153 2491 2504 (Pubitemid 47262039)
15. GR Jiang S Nikolova DP Clark 2001 Regulation of the ldhA gene, encoding the fermentative lactate dehydrogenase of Escherichia coli Microbiology 147 2437 2446
16. B Jungwirth D Emer I Brune N Hansmeier A Pühler BJ Eikmanns A Tauch 2008 Triple transcriptional control of the resuscitation promoting factor 2 (rpf2) gene of Corynebacterium glutamicum by the regulators of acetate metabolism RamA and RamB and the cAMP-dependent regulator GlxR FEMS Microbiol Lett 281 190 197
17. P Kiefer E Heinzle C Wittmann 2002 Influence of glucose, fructose and sucrose as carbon sources on kinetics and stoichiometry of lysine production by Corynebacterium glutamicum J Ind Microbiol Biotechnol 28 338 343 (Pubitemid 34753757)
18. HJ Kim TH Kim Y Kim HS Lee 2004 Identification and characterization of glxR, a gene involved in regulation of glyoxylate bypass in Corynebacterium glutamicum J Bacteriol 186 3453 3460 (Pubitemid 38661542)
19. S Kinoshita S Udaka M Shimono 1957 Studies on the amino acid fermentation. Part 1. Production of l-glutamic acid by various microorganisms J Gen Appl Microbiol 3 193 205 (Pubitemid 40667507)
20. TA Kohl J Baumbach B Jungwirth A Pühler A Tauch 2008 The GlxR regulon of the amino acid producer Corynebacterium glutamicum: in silico and in vitro detection of DNA binding sites of a global transcription regulator J Biotechnol 135 340 350
21. UK Laemmli 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 680 685
22. JT Larsson A Rogstam C von Wachenfeldt 2005 Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis Microbiology 151 3323 3335 (Pubitemid 41488915)
23. M Letek N Valbuena A Ramos E Ordóñez JA Gil LM Mateos 2006 Characterization and use of catabolite-repressed promoters from gluconate genes in Corynebacterium glutamicum J Bacteriol 188 409 423 (Pubitemid 43100528)
24. M Marino HC Ramos T Hoffmann P Glaser D Jahn 2001 Modulation of anaerobic energy metabolism of Bacillus subtilis by arfM (ywiD) J Bacteriol 183 6815 6821 (Pubitemid 33064195)
25. F Mat-Jan KY Alam DP Clark 1989 Mutants of Escherichia coli deficient in the fermentative lactate dehydrogenase J Bacteriol 171 342 348
26. Miller JH (1972) Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
27. C Péquignot CG Dussap JB Gros 1997 Intra- and extracellular concentrations of glutamate, lactate and acetate during growth of Corynebacterium glutamicum on different media J Ind Microbiol Biotechnol 18 312 318 (Pubitemid 27468890)
28. H Reents R Munch T Dammeyer D Jahn E Härtig 2006 The Fnr Regulon of Bacillus subtilis J Bacteriol 188 1103 1112 (Pubitemid 43146426)
29. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
30. M Schau Y Chen FM Hulett 2004 Bacillus subtilis YdiH is a direct negative regulator of the cydABCD operon J Bacteriol 186 4585 4595 (Pubitemid 38891021)
31. FW Studier BA Moffatt 1986 Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes J Mol Biol 189 113 130
32. Y Tanaka H Teramoto M Inui H Yukawa 2008 Regulation of expression of general components of the phosphoenolpyruvate: carbohydrate phosphotransferase system (PTS) by the global regulator SugR in Corynebacterium glutamicum Appl Microbiol Biotechnol 78 309 318
33. A Tauch O Kaiser T Hain A Goesmann B Weisshaar A Albersmeier T Bekel N Bischoff I Brune T Chakraborty J Kalinowski F Meyer O Rupp S Schneiker P Viehoever A Pühler 2005 Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora J Bacteriol 187 4671 4682 (Pubitemid 40880980)
34. K Toyoda H Teramoto M Inui H Yukawa 2008 Expression of the gapA gene encoding glyceraldehyde-3-phosphate dehydrogenase of Corynebacterium glutamicum is regulated by the global regulator SugR Appl Microbiol Biotechnol 81 291 301
35. K Toyoda H Teramoto M Inui H Yukawa 2009 Involvement of the LuxR-type transcriptional regulator, RamA, in regulation of expression of the gapA gene encoding glyceraldehyde-3-phosphate dehydrogenase of Corynebacterium glutamicum J Bacteriol 191 968 977
36. PTC van den Bogaard M Kleerebezem OP Kuipers WM de Vos 2000 Control of lactose transport, β-galactosidase activity, and glycolysis by CcpA in Streptococcus thermophilus: evidence for carbon catabolite repression by a non-phosphoenolpyruvate-dependent phosphotransferase system sugar J Bacteriol 182 5982 5989
37. AA Vertès M Inui M Kobayashi Y Kurusu H Yukawa 1993 Presence of mrr- and mcr-like restriction systems in coryneform bacteria Res Microbiol 144 181 185 (Pubitemid 23151408)
38. E Wang MC Bauer A Rogstam S Linse DT Logan C von Wachenfeldt 2008 Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex Mol Microbiol 69 466 478
39. H Yukawa CA Omumasaba H Nonaka P Kós N Okai N Suzuki M Suda Y Tsuge J Watanabe Y Ikeda AA Vertès M Inui 2007 Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R Microbiology 153 1042 1058 (Pubitemid 46605802)