Single molecule detection in nanofluidic digital array enables accurate measurement of DNA copy number

Analytical and Bioanalytical Chemistry

Volumn 394, Issue 2, 2009, Pages 457-467

  Bhat, Somanath ^a   Herrmann, Jan ^a   Armishaw, Paul ^a   Corbisier, Philippe ^a,b   Emslie, Kerry R ^a  

^a NATIONAL MEASUREMENT INSTITUTE   (Australia)

^b JOINT RESEARCH CENTRE   (Italy)

Author keywords

Bioanalytical methods; Biochips high throughput screening; Clinical biomedical analysis; Nucleic acids (DNA|RNA); PCR

Indexed keywords

ACCURATE MEASUREMENTS; BIOANALYTICAL METHODS; BIOCHIPS/HIGH THROUGHPUT SCREENING; CLINICAL/BIOMEDICAL ANALYSIS; COPY NUMBERS; DNA CONCENTRATIONS; DNA FRAGMENTS; DNA MOLECULES; PCR; PCR MEASUREMENTS; POLYMERASE CHAIN REACTIONS; RELATIVE UNCERTAINTIES; SINGLE MOLECULE AMPLIFICATIONS; SINGLE-MOLECULE DETECTIONS; SPATIAL DISTRIBUTION ANALYSIS; TEMPLATE MOLECULES; UNCERTAINTY ESTIMATES;

AMPLIFICATION; DNA; GENES; MOLECULES; NANOFLUIDICS; NUCLEIC ACIDS; RNA; TARGETS;

UNCERTAINTY ANALYSIS;

DNA;

ARTICLE; COMPUTER SIMULATION; DNA MICROARRAY; GENE DOSAGE; GENETICS; METHODOLOGY; MICROFLUIDICS;

COMPUTER SIMULATION; DNA; GENE DOSAGE; MICROFLUIDICS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 67349135284     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-009-2729-5     Document Type: Article

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