Mechanism of action of Rhodiola imbricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats

Food and Chemical Toxicology

Volumn 47, Issue 6, 2009, Pages 1239-1245

  Gupta, Vanita ^a   Lahiri, S S ^b   Sultana, S ^c   Kumar, Ratan ^a  

^a DEFENCE INSTITUTE OF PHYSIOLOGY AND ALLIED SCIENCES   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^c HAMDARD UNIVERSITY   (India)

Author keywords

Cold; Energy fuels; Glycolysis; Hypoxia; Krebs's cycle; Rhodiola

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CITRATE SYNTHASE; FATTY ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; HEXOKINASE; LACTIC ACID; RHODIOLA EXTRACT;

AEROBIC METABOLISM; ANAEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; COLD EXPOSURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; GLYCOGEN LIVER LEVEL; HYPOTHERMIA; HYPOXIA; IMMOBILIZATION STRESS; LACTATE BLOOD LEVEL; LIVER; MALE; MUSCLE TISSUE; NONHUMAN; PLANT ROOT; RAT; SINGLE DRUG DOSE;

ANIMALS; ANOXIA; BLOOD GLUCOSE; COLD TEMPERATURE; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; GLYCOGEN; GLYCOLYSIS; HYPOTHERMIA; LACTIC ACID; MALE; PLANT EXTRACTS; PLANT ROOTS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; RHODIOLA; STRESS, PSYCHOLOGICAL;

ANIMALIA; RATTUS; RHODIOLA;

EID: 67349131893     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.02.017     Document Type: Article

References (36)

1. Arora R., Chawla R., Sagar R., Prasad J., Sing S., Kumar R., Sharma A., Singh S., and Sharma R.K. Evaluation of radioprotective activities of Rhodiola imbricata Edgew - A high altitude plant. Mol. Cellular Biochem. 273 (2005) 209-223
2. Axelrod J., and Reisine T.D. Stress hormones their interaction and regulation. Science 224 (1984) 452-459
3. Balkrishna, and Bhatia B. Biophysical and physiological basis of human cold acclimatization. Defence Sci. J. 18 (1968) 29-38
4. Bergmeyer H.U., Grassl M., and Walter H. In: Bergmeyer H.U., Bergmeyer J., and Grassl M. (Eds). Methods of Enzymatic Analysis (1983), Verlag Chemie, Veinheim 185-186
5. Braun J.E.A., and Severson D.L. Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochemistry Journal 287 (1992) 337-347
6. Brekhman, I.I., 1980. Man and Biologically Active Substances. Pergmon Press, Oxford, 120 p.
7. Brekhman I.I., and Dardymov I.V. New substances of plant origin which increase non-specific resistance. Annu. Rev. Pharmacol. 9 (1969) 419-430
8. Brown R.P., Gerbarg P.L., and Ramazanov Z. Rhodiola rosea: a phytomedicinal overview. Herbalgram 56 (2002) 40-52
9. Chattopadhyay D.P. Adipose tissue metabolism during hypobaria. Defence Sci. J. 24 (1974) 155-162
10. Dede S., Deger Y., and Meral I. Effect of short-term hypothermia on lipid peroxidation and antioxidant enzyme activity in rats. J. Vet. Med. A. Physiol. Pathol. Clin. Med. 49 (2002) 286-288
11. Doubek J., Slosarkova S., Fleischer P., Mala G., and Skrivanek M. Metabolic and hormonal profiles of potentiated cold stress in lambs during early postnatal period. Czech. J. Anim. Sci. 48 10 (2003) 403-411
12. Good C.A., Kramer H., and Somogyi M. The determination of glycogen. J. Biol. Chem. 100 (1933) 485-491
13. Gumuslu S., Sarikcioglu S.B., Sahin E., Yargicoglu P., and Agar A. Influences of different stress models on the antioxidant status and lipid peroxidation in rat erythrocytes. Free Radic. Res. 36 (2002) 1277-1282
14. Gupta A., Kumar R., Upadhayay N.K., Pal K., Kumar R., and Sawhney R.C. Effects of Rhodiola imbricata on dermal wound healing. Planta Med. 73 (2007) 774-777
15. Gupta V., Saggu S., Tulsawani R.K., Sawhney R.K., and Kumar R. A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome. Food Chem. Toxicol. 46 (2008) 1645-1652
16. Hisao K., Ikuko N., Sadao S., Seiki H., and Yoshihori I. Mechanism of oxidative stress in skeletal muscle atrophied by immobilization. Am. J. Physiol. 265 (1993) E839-E844
17. Huguet F., Guerraoui A., Barrier L., Guilloteau D., Tallineau C., and Chalon S. Changes in excitatory amino acid levels and tissue energy metabolites of neonate rat brain after hypoxia and hypoxia-ischemia. Neurosci. Lett. 240 2 (1998) 102-106
18. Kanupriya, Prasad D., Sairam M., Kumar R., Sawhney R.C., Sharma S.K., Illavazhagan G., Kumar D., and Banerjee PK. Cytoprotective and antioxidant activity of Rhodiola imbricata against tert-butyl hydroperoxide induced oxidative injury in U-937 human macrophage. Mol. Cell. Biochem. 275 (2005) 1-6
19. Kumar R., Divekar H.M., Gupta A.K., Shyam R., and Srivastava K.K. Enhanced thermogenesis in rats by Panax ginseng, multivitamins and minerals. Int. J. Biometeorol. 39 (1996) 187-191
20. Kumar R., Grover S.K., Shyam R., Divekar H.M., Gupta A.K., and Srivastava K.K. Enhanced thermogenesis in rats by a Composite Indian Herbal Preparation-I (CIHP-I) and its mechanism of action. J. Altern. Complement. Med. 5 (1999) 245-251
21. Kumar R., Shyam R., Divekar H.M., Pahwa M.L., and Srivastava K.K. Mechanism of increased tolerance to hypothermia after Composite Indian Herbal Preparation II administration. J. Altern. Complement. Med. 6 (2000) 509-517
22. Kumar R., Divekar H.M., Gupta V., and Srivastava K.K. Antistress and adaptogenic activity of lecithin supplementation. J. Altern. Complement. Med. 8 (2002) 487-492
23. Lohr G.W., and Waller H.D. Glucose-6-phosphate dehydrogenase. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis (1974), Verlag Chemie, Weinheim 636-643
24. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
25. Mishra K.P., Padwad Y.S., Jain M., Karan D., Ganju L., and Sawhney R.C. Aqueous extract of Rhodiola imbricata rhizome stimulates proinflammatory mediators via phosphorylated 1 kB and transcription factor nuclear factor-kB. Immunopharmacol. Immunotoxicol. 28 (2006) 201-212
26. Nelson N. A photometric adaptation of the Somogyi method for the determination of glucose. J. Biol. Chem. 153 (1944) 375-380
27. Norberg K., Quistorff B., and Siesjo B.K. Effect of hypoxia of 10-45 seconds duration on energy metabolism in the cerebral cortex of unanesthetized and anesthetized rats. Acta Physiol. Scand. 95 (1975) 301-310
28. Ramachandran U., Divekar H.M., Grover S.K., and Srivastava K.K. New experimental model for evaluation of adaptogenic products. J. Ethnopharmacol. 29 (1990) 275-281
29. Riley V. Adaptation of orbital bleeding technique to rapid serial blood studies. Proc. Soc. Exp. Biol. Med. 104 (1960) 751-754
30. Saggu, S., 2007. Adaptogenic and anti-stress activity of Seabuckthorn leaf. Ph.D Thesis submitted to Jamia Hamdard University, Delhi, India.
31. Saggu S., Gupta V., Sawhney R.C., Rai P.K., and Kumar R. Analysis of heavy metal in herbal extracts of high altitude growing plants Hippophae rhamnoides and Rhodiola imbricata. Toxicol. Int. 13 (2006) 111-117
32. Selye H. The Stress of Life (1950), Mc Graw Hill Book Co., New York
33. Shepherd D., and Garland P.B. Citrate synthase from rat liver. In: Lowenstein J.M. (Ed). Methods in Enzymology vol. 13 (1969), Academic Press, New York 1-16
34. Supowit, S.C., Harris, B.G., 1982. Hexokinase from Ascaris suum muscle. In: Wood, W. (Ed.), Methods in Enzymology (Carbohydrate Metabolism), vol. 90, part C, pp. 21-25.
35. Talwar, G.P., Srivastava, L.M., Moudgil, K.D. (Eds.), 1989. Textbook of Biochemistry and Human Biology, second ed., Prentice Hall of India Private Limited, New Delhi.
36. Zhang, H.H., Pu, W.R., Jia, S.N., Sun, Q., 2004. The effect of Rhodiola kirillowii on the lactic acid content of heart and brain tissue in hypoxia mice. The Qing Hai Provincial Hospital of Traditional Chinese Medicine, Xining, Qinghai, PR China. High Altitude Medicine & Biology, Abstract No. 64, Vol. 5, No. 2.