Kochujang, a Korean fermented red pepper plus soybean paste, improves glucose homeostasis in 90% pancreatectomized diabetic rats

Nutrition

Volumn 25, Issue 7-8, 2009, Pages 790-799

  Kwon, Dae Young ^a   Hong, Sang Mee ^b   Ahn, Il Sung ^b   Kim, Young Suk ^c   Shin, Dong Wha ^c   Park, Sunmin ^b  

^a Korea Food Research Institute   (South Korea)

^b Hoseo University   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Insulin secretion; Insulin sensitivity; Insulin signaling; Red pepper; Soybeans

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; GLYCOGEN; INSULIN; LEPTIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS PARASITICUS; BACILLUS SUBTILIS; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DIABETES MELLITUS; FERMENTATION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HOMEOSTASIS; IMMUNOBLOTTING; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; KOCHUJANG; KOREA; LIPID DIET; MALE; MALT; NONHUMAN; NUTRIENT; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PEPPER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RICE; SOYBEAN;

ANIMALS; BODY WEIGHT; CAPSICUM; CEREALS; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; FERMENTATION; GLUCOSE; GLYCOGEN; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LEPTIN; MALE; ORYZA SATIVA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHORYLATION; PLANT PREPARATIONS; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SOY FOODS; SOYBEANS; STAT3 TRANSCRIPTION FACTOR; TRIGLYCERIDES;

ASPERGILLUS SOJAE; CAPSICUM ANNUUM VAR. ANNUUM; GLYCINE MAX; RATTUS;

EID: 67349128571     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2008.12.006     Document Type: Article

References (39)

1. DeFronzo R.A., and Ferrannini E. Regulation of intermediary metabolism during fasting and feeding. In: DeGroot L.J., and Jameson J.L. (Eds). Endocrinology (2001), WB Saunders, Philadelphia 737-775
2. Taylor S.I. Deconstructing type 2 diabetes. Cell 97 (1999) 9-12
3. Kim J.K., Kim Y.J., Fillmore J.J., Chen Y., Moore I., Lee J., et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108 (2001) 437-446
4. Cockram C.S. The epidemiology of diabetes mellitus in the Asia-Pacific region. Hong Kong Med J 6 (2000) 43-52
5. Park S., Park C.H., and Jang J.S. Antecedent intake of traditional Asian-style diets exacerbates pancreatic β-cell function, growth and survival after Western-style diet feeding in weaning male rats. J Nutr Biochem 17 (2006) 307-318
6. Bessesen D.H. The role of carbohydrates in insulin resistance. J Nutr 131 (2001) 2782S-2786
7. Kahn S.E. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46 (2003) 3-19
8. Ahuja K.D., Robertson I.K., Geraghty D.P., and Ball M.J. Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am J Clin Nutr 84 (2006) 63-69
9. Spiller F., Alves M.K., Vieira S.M., Carvalho T.A., Leite C.E., Lunardelli A., et al. Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation. J Pharm Pharmacol 60 (2008) 473-478
10. Suri A., and Szallasi A. The emerging role of TRPV1 in diabetes and obesity. Trends Pharmacol Sci 29 (2008) 29-36
11. Razavi R., Chan Y., Afifiyan F.N., Liu X.J., Wan X., Yantha J., et al. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes. Cell 127 (2006) 1123-1135
12. Alevizos A., Mihas C., Mariolis A., and Larios G. Insulin secretion and capsaicin. Am J Clin Nutr 85 (2007) 1165-1166
13. Kwon D.Y., Jang J.S., Hong S.M., Lee J.E., Sung S.R., Park H.R., et al. Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. Eur J Nutr 46 (2007) 44-52
14. Nikander E., Tiitinen A., Laitinen K., Tikkanen M., and Ylikorkala O. Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women. J Clin Endocrinol Metab 89 (2004) 3567-3572
15. Veloso R.V., Latorraca M.Q., Arantes V.C., Reis M.A., Ferreira F., Boschero A.C., et al. Soybean diet improves insulin secretion through activation of cAMP/PKA pathway in rats. J Nutr Biochem 19 (2008) 778-784
16. Hosokawa Y.A., Hosokawa H., Chen C., and Leahy J.L. Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagons like peptide-1 (7-37). J Clin Invest 97 (1996) 180-186
17. Choi S.B., Jang J.S., and Park S. Estrogen and exercise may enhance beta-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats. Endocrinology 146 (2005) 4786-4794
18. American Institute of Nutrition. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123 (1993) 1939-1951
19. Rossetti L., Shulman G.I., Zawalich W., and DeFronzo R.A. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 80 (1987) 1037-1044
20. Frontoni S., Choi S.B., Banduch D., and Rossetti L. In vivo insulin resistance induced by amylin primarily through inhibition of insulin-stimulated glycogen synthesis in skeletal muscle. Diabetes 40 (1991) 568-573
21. Sebokova E., Klimes I., Moss R., Stolba P., Wiersma M.M., and Mitkova A. Muscle GLUT 4 protein levels and impaired triglyceride metabolism in streptozotocin diabetic rats. Effect of a high sucrose diet and fish oil supplementation. Ann N Y Acad Sci 683 (1993) 218-227
22. Choi S.H., Suh B.S., Kozukue E., Kozukue N., Levin C.E., and Friedman M. Analysis of the contents of pungent compounds in fresh Korean red peppers and in pepper-containing foods. J Agric Food Chem 54 (2006) 9024-9032
23. Shin D.H., Kim D.H., Choi U., Lim M.S., and An E.Y. Taste components of traditional kochujang prepared with various raw materials. Korean J Food Sci Technol 29 (1997) 913-918
24. Lee S.H., Gong G.L., Jeong G.O., and Park K.Y. Decreasing effect of kochujang on body weight and lipid levels of adipose tissues and serum in rats fed a high-fat diet. Korean J Food Sci Nutr 32 (2003) 882-886
25. Karlsson S., Scheurink A.J., Steffens A.B., and Ahrén B. Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice. Am J Physiol Regul Integr Comp Physiol 267 (1994) R1071-R1077
26. Choi Y.M., and Suh H.J. Pharmacological effects of fermented red pepper. Phytother Res 18 (2004) 884-888
27. Diepvens K., Westerterp K.R., and Westerterp-Plantenga M.S. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 292 (2007) R77-R85
28. Ahuja K.D., Robertson I.K., Geraghty D.P., and Ball M.J. The effect of 4-week chilli supplementation on metabolic and arterial function in humans. Eur J Clin Nutr 61 (2007) 326-333
29. Gram D.X., Ahrén B., Nagy I., Olsen U.B., Brand C.L., Sundler F., et al. Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. Eur J Neurosci 25 (2007) 213-223
30. Wagner J.D., Zhang L., Shadoan M.K., Kavanagh K., Chen H., Tresnasari K., et al. Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys. Metabolism 57 (2008) S24-S31
31. Torre-Villalvazo I., Tovar A.R., Ramos-Barragán V.E., Cerbón-Cervantes M.A., and Torres N. Soy protein ameliorates metabolic abnormalities in liver and adipose tissue of rats fed a high fat diet. J Nutr 138 (2008) 462-468
32. de Arruda Oliveira E., Gomes Cheim L.M., Veloso R.V., Arantes V.C., Reis M.A., Carneiro E.M., et al. Nutritional recovery with a soybean flour diet improves the insulin response to a glucose load without modifying glucose homeostasis. Nutrition 24 (2008) 76-83
33. Veloso R.V., Latorraca M.Q., Arantes V.C., Reis M.A., Ferreira F., Boschero A.C., et al. Soybean diet improves insulin secretion through activation of cAMP/PKA pathway in rats. J Nutr Biochem 19 (2008) 778-784
34. Gram D.X., Hansen A.J., Wilken M., Elm T., Svendsen O., Carr R.D., et al. Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur J Endocrinol 153 (2005) 963-969
35. Tolan I., Ragoobirsingh D., and Morrison E.Y. The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models. Phytother Res 15 (2001) 391-394
36. Viollet B., Mounier R., Leclerc J., Yazigi A., Foretz M., and Andreelli F. Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders. Diabetes Metab 33 (2007) 395-402
37. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 13 (2007) 332-339
38. Andreelli F., Foretz M., Knauf C., Cani P.D., Perrin C., Iglesias M.A., et al. Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology 147 (2006) 2432-2441
39. Long Y.C., and Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116 (2006) 1776-1783