Free-flow isoelectric focusing microfluidic device with glass coating by sol-gel methods

Current Applied Physics

Volumn 9, Issue 2 SUPPL., 2009, Pages

  Yang, Kwang Suk ^a   Clementz, Philippe ^a   Park, Tae Jung ^a,b   Lee, Seok Jae ^c   Park, Jong Pil ^a,b   Kim, Do Hyun ^a   Lee, Sang Yup ^a,b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c National Nano Fab Center (NNFC)   (South Korea)

Author keywords

Free flow isoelectric focusing; Isoelectric point; Lab on a chip; PDMS microchannel

Indexed keywords

COATED DEVICES; FOCUSING CONDITIONS; FOCUSING TIME; FREE-FLOW ISOELECTRIC FOCUSING; GLASS COATING; GLASS SUBSTRATES; ISOELECTRIC FOCUSING; ISOELECTRIC POINT; LAB-ON-A-CHIP; MICRO-FLUIDIC DEVICES; MICROFLUIDIC CHANNEL; MODEL PROTEINS; PALLADIUM ELECTRODES; PDMS MICROCHANNEL; PDMS MICROCHANNELS; PDMS REPLICA; PH GRADIENTS; PH INDICATOR; PRE-CONCENTRATION; PREFRACTIONATION; PROTEIN MIXTURES; SOL-GEL METHODS;

COATINGS; ELECTRIC FIELDS; ELECTRIC POTENTIAL; ELECTRODES; ELECTROPHORESIS; FLUIDIC DEVICES; FOCUSING; GELATION; GLASS; MICROCHANNELS; PALLADIUM; PH EFFECTS; SILICONES; SOL-GEL PROCESS; SOLS;

GLASS BONDING;

EID: 67349125813     PISSN: 15671739     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cap.2008.12.032     Document Type: Article

References (20)

1. Reyes D.R., Iossifidis D., Auroux P.A., and Manz A. Micro total analysis systems. 1. Introduction, theory, and technology. Anal. Chem. 74 (2002) 2623-2636
2. Auroux P.-A., Iossifidis D., Reyes D.R., and Manz A. Micro total analysis systems. 2. Analytical standard operations and applications. Anal. Chem. 74 12 (2002) 2637-2652
3. Chin C.D., Linder V., and Sia S.K. Lab-on-a-chip devices for global health. Lab Chip 7 (2007) 41-57
4. Gao J., Yin X.F., and Fang Z.L. Integration of single cell injection, cell lysis, separation and detection of intracellular constituents on a microfluidic chip. Lab Chip 4 (2004) 47-52
5. Dittrich P.S., Tachikawa K., and Manz A. Micro total analysis systems. Latest advancements and trends. Anal. Chem. 78 (2006) 3887-3908
6. Broyles B.S., Jacobson S.C., and Ramsey J.M. Sample filtration, concentration, and separation integrated on microfluidic devices. Anal. Chem. 75 (2003) 2761-2767
7. Kohlheyer D., Eijkel J.C.T., van den Berg A., and Schasfoort R.B.M. Miniaturizing free-flow electrophoresis - A critical review. Electrophoresis 29 (2008) 977-993
8. Erickson D., Liu X., Krull D., and Li D. Electrokinetically controlled DNA hybridization microfluidic chip enabling rapid target analysis. Anal. Chem. 76 (2004) 7269-7277
9. Easley C.J., Karlinsey J.M., Bienvenue J.M., Legendre L.A., Roper M.G., Feldman S.H., Hughes M.A., Hewlett E.L., Merkel T.J., Ferrance J.P., and Landers J.P. A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability. Proc. Natl. Acad. Sci. 103 (2006) 19272-19277
10. Erickson D., and Li D.Q. Integrated microfluidic devices. Anal. Chim. Acta 507 (2004) 11-26
11. Albrecht J.W., and Jensen K.F. Micro free-flow IEF enhanced by active cooling and functionalized gels. Electrophoresis 27 (2006) 4960-4969
12. Quake S.R., and Scherer A. From micro-to nanofabrication with soft materials. Science 290 (2000) 1536-1540
13. Whitesides G.M. The origins and the future of microfluidics. Nature 442 (2006) 368-373
14. McDonald J.C., Duffy D.C., Anderson J.R., Chiu D.T., Wu H., Schueller O.J.A., and Whitesides G.M. Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21 (2000) 27-40
15. Kakuta K., Bessoth F.G., and Manz A. Microfabricated devices for fluid mixing and their application for chemical synthesis. Chem. Rec. 1 (2001) 395-405
16. Abate A.R., Lee D., Do T., Holtze C., and Weitz D.A. Glass coating for PDMS microfluidic channels by sol-gel methods. Lab Chip 8 (2008) 516-518
17. Brinker C.J., and Scherer G.W. Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing (1990), Academic Press, Boston
18. Sambrook J., and Russell D. Molecular Cloning: A Laboratory Manual. third ed. (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
19. Janasek D., Schilling M., Manz A., and Franzke J. Electrostatic induction of the electric field into free-flow electrophoresis devices. Lab Chip 6 (2006) 710-713
20. Cabrera C.R., Finlayson B.A., and Yager P. Formation of natural pH gradients in a microfluidic device under flow conditions: model and experimental validation. Anal. Chem. 73 3 (2001) 658-666