Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3318-3322

  Wang, Liutang ^a,b   Zhang, Bin ^b   Ji, Jianxin ^b   Li, Bogang ^b   Yan, Jufang ^b   Zhang, Weiyu ^b   Wu, Yong ^a   Wang, Xuechao ^b  

^a SICHUAN UNIVERSITY   (China)

^b Chengdu Di'Ao Pharmaceutical Company   (China)

Author keywords

2 Cyanopyrrolidine; Anti diabetic agent; Dipeptidyl peptidase IV inhibitors; Imidazolidin derivatives

Indexed keywords

1 [2 [2 [3 (3,4 DIMETHOXYPHENYL) 2 OXOIMIDAZOLIDIN 1 YL]ETHYLAMINO]ACETYL]PYRROLIDINE 2 CARBONITRILE; ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV; IMIDAZOLIDINE 2 CYANOPYRROLIDINE DERIVATIVE; IMIDAZOLIDINE DERIVATIVE; SAXAGLIPTIN; SITAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50;

ANTIGENS, CD26; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DESIGN; HUMANS; IMIDAZOLINES; INHIBITORY CONCENTRATION 50; PYRROLIDINES;

EID: 67349123804     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.021     Document Type: Article

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