Protein and glutamine kinetics during counter-regulatory failure in type 1 diabetes

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 19, Issue 5, 2009, Pages 352-357

  Battezzati, A ^a,b   Benedini, S ^a   Sereni, L P ^a   DeTaddeo, F ^a   Maffi, P ^a   Secchi, A ^a   Luzi, L ^a,c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Intl Ctr Assess of Nutr Status   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Glucagon; Gluconeogenesis; Glutamine; Hypoglycaemia

Indexed keywords

ADRENALIN; GLUCAGON; GLUCOSE; GLUTAMINE; INSULIN; LEUCINE;

ADULT; ARTICLE; BLOOD; CASE CONTROL STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METABOLIC CLEARANCE RATE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; BLOOD GLUCOSE; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; FEMALE; GLUCAGON; GLUCONEOGENESIS; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLUTAMINE; HUMANS; HYPOGLYCEMIA; INSULIN; LEUCINE; MALE; METABOLIC CLEARANCE RATE;

EID: 67349120972     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2008.03.009     Document Type: Article

References (30)

1. Battezzati A., Benedini S., Fattorini A., Piceni Sereni L., and Luzi L. Effect of hypoglycemia on amino acid and protein metabolism in healthy humans. Diabetes 49 9 (2000) 1543-1551
2. De Feo P., Perriello G., Santeusanio F., Brunetti P., Bolli G., and Haymond M.W. Differential effects of insulin-induced hypoglycaemia on the plasma branched-chain and non-branched-chain amino acid concentrations in humans. Diabetes Metab 18 (1992) 277-282
3. Meyer C., Dostou J.M., and Gerich J.E. Role of the human kidney in glucose counterregulation. Diabetes 48 (1999) 943-948
4. Fukagawa N.K., Minaker K.L., Rowe J.W., Goodman M.N., Matthews D.E., Bier D.M., et al. Insulin-mediated reduction of whole body protein break-down: dose-response effects of leucine metabolism in postabsorptive men. J Clin Invest 76 (1985) 2306-2311
5. Castellino P., Luzi L., Simonson D.C., Haymond M., and DeFronzo R.A. Effect of insulin and plasma amino acid concentrations on leucine metabolism in man: role of substrate availability on estimates of whole body protein synthesis. J Clin Invest 80 (1987) 1784-1793
6. Meyer C., Woerle H.J., and Gerich J. Paradoxical changes of muscle glutamine release during hyperinsulinemia euglycemia and hypoglycemia in humans: further evidence for the glucose-glutamine cycle. Metabolism 53 9 (2004) 1208-1214
7. Battezzati A., Simonson D.C., Luzi L., and Matthews D.E. Glucagon increases glutamine uptake without affecting glutamine release in humans. Metabolism 47 (1998) 713-723
8. Stumvoll M., Meyer C., Kreider M., Perriello G., and Gerich J. Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans. Metabolism 47 10 (1998) 1227-1232
9. Krishna M.G., Coker R.H., Lacy D.B., Zinker B.A., Halseth A.E., and Wasserman D.H. Glucagon response to exercise is critical for accelerated hepatic glutamine metabolism and nitrogen disposal. Am J Physiol Endocrinol Metab 279 3 (2000) E638-E645
10. Cryer P.E. The pathophysiology of hypoglycaemia in diabetes. Diabetes Nutr Metab 15 5 (2002) 330-333
11. Gerich J.E. Glucose counterregulation and its impact on diabetes mellitus. Diabetes 37 12 (1988 Dec) 1608-1617
12. Amiel S.A., Tamborlane W.V., Sacca L., and Sherwin R.S. Hypoglycemia and glucose counterregulation in normal and insulin-dependent diabetic subjects. Diabetes Metab Rev 4 1 (1988) 71-89
13. Bolli G.B. Counterregulatory mechanisms to insulin-induced hypoglycemia in humans: relevance to the problem of intensive treatment of IDDM. J Pediatr Endocrinol Metab 11 Suppl 1 (1998) 103-115
14. Cryer P.E. Hypoglycemia is the limiting factor in the management of diabetes. Diabetes Metab Res Rev 15 1 (1999) 42-46
15. Battezzati A., Caumo A., Fattorini A., Sereni L.P., Coppa J., Romito R., et al. Amino acid kinetics during the anhepatic phase of liver transplantation. Diabetes 51 6 (2002) 1690-1698
16. Grassi G., Seravalle G., Cattaneo B.M., Lanfranchi A., Vailati S., Giannattasio C., et al. Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation 92 (1995) 3206-3211
17. Steele R. Influences of glucose loading and of injected insulin of hepatic glucose output. Ann NY Acad Sci 82 (1959) 420-431
18. Battezzati A., Luzi L., Perseghin G., Bianchi E., Spotti D., Secchi A., et al. Persistence of counter-regulatory abnormalities in insulin-dependent diabetes mellitus after pancreas transplantation. Eur J Clin Invest 24 11 (1994) 751-758
19. Joseph S.E., Heaton N., Potter D., Pernet A., Umpleby M.A., and Amiel S.A. Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation. Diabetes 49 3 (2000) 450-456
20. Stumvoll M., Chintalapudi U., Perriello G., Welle S., Gutierrez O., and Gerich J. Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J Clin Invest 96 5 (1995) 2528-2533
21. Cersosimo E., Molina P.E., and Abumrad N.N. Renal lactate metabolism and gluconeogenesis during insulin-induced hypoglycemia. Diabetes 47 7 (1998) 1101-1106
22. Lacey J.M., and Wilmore D.W. Is glutamine a conditionally essential amino acid?. Nutr Rev 48 (1990) 297-309
23. Boyle P.J. Alterations in brain glucose uptake and hypoglycaemia unawareness. Diabetes Nutr Metab 15 5 (2002) 334-340
24. Nurjhan N., Bucci A., Perriello G., Stumvoll M., Dailey G., Bier D.M., et al. Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest 95 1 (1995) 272-277
25. Lecavalier L., Bolli G., Cryer P., and Gerich J. Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am J Physiol 256 (1989) E844-E851
26. Kelly A., Li C., Gao Z., Stanley C.A., and Matschinsky F.M. Glutaminolysis and insulin secretion: from bedside to bench and back. Diabetes 51 Suppl 3 (2002) S421-S426
27. Li C., Buettger C., Kwagh J., Matter A., Daikhin Y., Nissim I.B., et al. A signaling role of glutamine in insulin secretion. J Biol Chem 279 14 (2004 Apr 2) 13393-13401
28. Stanley C.A., Lieu Y.K., Hsu B.Y., Burlina A.B., Greenberg C.R., Hopwood N.J., et al. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 338 (1998) 1352-1357
29. Auer R.N. Hypoglycemic brain damage. Metab Brain Dis 19 3-4 (2004) 169-175
30. Battezzati A., and Bertoli S. Methods of measuring metabolism during surgery in humans: focus on the liver-brain relationship. Curr Opin Clin Nutr Metab Care 7 5 (2004) 523-530