Doppel gene polymorphisms in Portuguese sheep breeds: Insights on ram fertility

Animal Reproduction Science

Volumn 114, Issue 1-3, 2009, Pages 157-166

  Pereira, R M ^a   Mesquita, P ^a   Batista, M ^b   Baptista, M C ^a   Barbas, J P ^a   Pimenta, J ^a,b   Santos, I C ^d   Marques, M R ^c   Vasques, M I ^a   Silva Pereira, M ^a   Santos Silva, F ^a   Oliveira Sousa, M C ^a   Fontes, C M G ^b   Horta, A E M ^a   Prates, J A M ^b   Marques, C C ^a  

^a L INIA   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c UNIVERSIDADE CATÓLICA PORTUGUESA   (Portugal)

^d UNIVERSITY OF ALGARVE   (Portugal)

Author keywords

Fertility; Genetic variability; Polymorphism; Prion like protein Doppel; Ram

Indexed keywords

ACROSOME REACTION; ANIMAL; ARTICLE; FERTILITY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; MALE; PHYSIOLOGY; PORTUGAL; PRION; SHEEP; SPERMATOZOON;

ACROSOME REACTION; ANIMALS; FERTILITY; GENOTYPE; MALE; POLYMORPHISM, GENETIC; PORTUGAL; PRIONS; SHEEP; SPERMATOZOA;

ANIMALIA; DORCATRAGUS MEGALOTIS; GALEGA; MUS; OVIS; OVIS ARIES;

EID: 67349119029     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anireprosci.2008.10.003     Document Type: Article

References (33)

1. Alvarez, L., Fuertes, M., San Primitivo, F., Garcia-Marin, F., Arranz, J.J., 2006. Variabilidad genética en la región codificante del gen Doppel (PRND) en ovejas afectadas de scrapie en Castilla y León. XIII Reunion Nacional de Mejora Genética Animal, 28-30 de Junio, Gijon-Spain (http://www.dcam.upv.es/acteon/CONGRESOS/XIIIReunionMGGIJON/DocsXIII/LAl varez_XIII.pdf).
2. Baylis M., and Goldmann W. The genetics of scrapie in sheep and goats. Curr. Mol. Med. 4 (2004) 385-396
3. Behrens A., Brandner S., Genoud N., and Aguzzi A. Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel. EMBO Rep. 2 (2001) 347-352
4. Behrens A., Genoud N., Naumann H., Rülicke T., Janett F., Heppner F.L., Ledermann B., and Aguzzi A. Absence of the prion protein homologue Doppel causes male sterility. EMBO J. 21 (2002) 3652-3658
5. Carcangiu, V., Vacca, G.M., Mura, M.C., Dettori, M.L., Pazzola, M., Luridiana, S., Bini, P.P., in press. Relationship between MTNR1A melatonin receptor gene polymorphism and seasonal reproduction in different goat breeds. Anim. Reprod. Sci., doi:10.1016/j.animreprosci.2007.12.014
6. Chesebro B. Grand ideas floating freely. Conference of the new prion biology: basic science, diagnosis and therapy. Embo Rep. 3 (2002) 1123-1126
7. Comincini S., Foti M.G., Tranulis M.A., Hills D., Di Guardo G., Vaccari G., Williams J.L., Harbitz I., and Ferretti L. Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PRND). Mamm. Genome 12 (2001) 729-733
8. Duan J., Wainwright M.S., Comeron J.M., Saitou N., Alan R., Sanders A.R., Gelernter J., and Gejman P.V. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum. Mol. Genet. 12 (2003) 205-216
9. Ehling C., Rath D., Struckmann C., Frenzel A., Schindler L., and Niemann H. Utilization of frozen-thawed epididymal ram semen to preserve genetic diversity in Scrapie susceptible sheep breeds. Theriogenology 66 (2006) 2160-2164
10. Espenes A., Harbitz I., Skogtvedt S., Fuglestveit R., Berg K.A., Dick G., Krogenaes A., and Tranuli M.A. Dynamic expression of the prion-like protein Doppel in ovine testicular tissue. Int. J. Androl. 29 (2006) 400-408
11. Essalmani R., Taourit S., Besnard N., and Vilotte J.L. Sequence determination and expression of the ovine Doppel-encoding gene in transgenic mice. Gene 285 (2002) 287-290
12. Gama L.T., Carolino M.I., Santos-Silva M.F., Pimenta J., and Costa M.S. Prion protein genetic polymorphisms and breeding strategies in Portuguese breeds of sheep. Livest. Sci. 99 (2006) 175-184
13. Kimchi-Sarfaty C.A., Jung M.I., Kim I., Sauna Z.E., Calcagno A.M., Ambudkar S., and Gottesman M.M. "Silent" polymorphism in the MDR1 gene changes substrate specificity. Science 315 (2007) 525-528
14. Kretzschmar H.A., Stowring L.E., Westaway D., Stubblebine W.H., Prusiner S.B., and Dearmond S.J. Molecular cloning of a human prion protein Cdna. DNA 5 (1986) 315-324
15. Lipsky S., Brandt H., Lühken G., and Erhardt G. Analysis of prion protein genotypes in relation to reproduction traits in local and cosmopolitan German sheep breeds. Anim. Reprod. Sci. 103 (2008) 69-77
16. Marques C.C., Barbas J.P., Baptista M.C., Vasques M.I., Pereira R.M., Cavaco-Gonçalves S., Mascarenhas R.M., and Horta A.E.M. Reproduction in the local ovine Saloia breed-results on seasonal and individual factors affecting fresh and frozen semen performance, in vivo and in vitro fertility. In: Ramalho Ribeiro J., Horta A.E.M., Mosconi C., and Rosati A. (Eds). Animal Products from Mediterranean Area (2006), EAAP Publications 325-330
17. Mesquita P., Batista M., Marques M.R., Santos I.C., Pimenta J., Santos Silva F., Sousa C.O., Carolino M.I., Horta A.E.M., Prates J.A., and Pereira R.M. Doppel gene polymorphisms and their relation to scrapie susceptibility in Portuguese sheep breeds. In: EAAP (Ed). Proceedings of 58th Annual Meeting of the European Association for Animal Production. Dublin Ireland, August 26-29 (2007) 71
18. Mesquita P., Batista M., Marques M.R., Santos I.C., Pimenta J., Santos Silva F., Sousa C.O., Horta A.E.M., Prates J.A., and Pereira R.M. Doppel gene polymorphisms: differences between Portuguese goat and sheep breeds. In: SPRA (Ed). Proceedings of VI Symposium of the Portuguese Animal Reproduction Society. Évora, March 16-18 (2007) 66-67
19. Moore R.C., Lee I.Y., Silverman G.L., Harrison P.M., Strome R., Heinrich C., Karunaratne A., Pasternak S.H., Chishti M.A., Liang Y., Mastrangelo, Wang K., Smit A.F., Katamine S., Carlson G.A., Cohen F.E., Prusiner S.B., Melton D.W., Tremblay P., Hood L.E., and Westaway D. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel. J. Mol. Biol. 292 (1999) 797-817
20. Moore R.C., Mastrangelo P., Bouzamondo E., Heinrich C., Legname G., Prusiner S.B., Hood L., Westaway D., DeArmond S.J., and Tremblay P. Doppel-induced cerebellar degeneration in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 15288-15293
21. Morris L.H.A., Johnson W.H., Leibo S.P., and Buckrell B.C. Relationship between the characteristics of frozen-thawed ram spermatozoa and in vitro embryo production. Reprod. Fertil. Dev. 13 (2001) 193-201
22. Paisley D., Banks S., Selfridge J., McLennan N.F., Ritchie A.M., McEwan C., Irvine D.S., Saunders P.T., Manson J.C., and Melton D.W. Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am. J. Pathol. 164 (2004) 2279-2288
23. Peoc'h K., Serres C., Frobert Y., Martin C., Lehmann S., Chasseigneauc S., Sazdovitch V., Grassi J., Jouannet P., Launay J., and Laplanche J. The human "prion-like" protein Doppel is expressed in both Sertoli cells and spermatozoa. J. Biol. Chem. 277 (2002) 43071-43078
24. Perez L.J., Valcarcel A., de las Heras M.A., Moses D.F., and Baldassarre H. In vitro capacitation and induction of acrosomal exocytosis in ram spermatozoa as assessed by the chlortetracycline assay. Theriogenology 45 (1996) 1037-1046
25. Rivera-Milla E., Oidtmann B., Panagiotidis C.H., Baier M., Sklaviadis T., Hoffmann R., Zhou Y., Solis G.P., Stuermer C.A., and Málaga-Trillo E. Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons. FASEB J. 20 (2006) 317-319
26. Rondena M., Ceciliania F., Comazzia S., Pocacquaa V., Bazzocchia C., Luvonib C., Chigionib S., and Paltrinieri S. Identification of bovine Doppel protein in testis, ovary and ejaculated spermatozoa. Theriogenology 63 (2005) 1195-1206
27. Rousset F. Genepop'007: a complete re-implementation of the genepop software for Windows and Linux. Mol. Ecol. Resour. 8 (2008) 103-106
28. Statsoft Inc. STATISTICA for Windows [Computer program manual] (1995), Statsoft Inc., Tulsa, OK
29. Serres C., Peoc'h K., Courtot A.M., Lesaffre C., Jouannet P., and Laplanche J.L. Spatio-developmental distribution of the prion-like protein Doppel in mammalian testis: a comparative analysis focusing on its presence in the acrosome of spermatids. Biol. Reprod. 74 (2006) 816-823
30. Silverman G.L., Qin K., Moore R.C., Yang Y., Mastrangelo P., Tremblay P., Prusiner S.B., Cohen F.E., and Westaway D. Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss. J. Biol. Chem. 275 (2000) 26834-32641
31. Tranulis M.A., Espenes A., Comincini S., Skretting G., and Harbitz I. The PrP-like protein Doppel gene in sheep and cattle: cDNA sequence and expression. Mamm. Genome 12 (2001) 376-379
32. Uboldi C., Del Vecchio I., Foti M.G., Azzalin A., Paulis M., Raimondi E., Vaccari G., Agrimi U., Di Guardo G., Comincini S., and Ferretti L. Prion-like Doppel gene (PRND) in the goat: genomic structure, cDNA, and polymorphisms. Mamm. Genome 16 (2005) 963-971
33. Vaccari G., Di Bari M.A., Morelli L., Nonno R., Chiappini B., Antonucci G., Marcon S., Esposito E., Fazzi P., Palazzini N., Troiano P., Petrella A., Di Guardo G., and Agrimi U. Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie. J. Gen. Virol. 87 (2006) 1395-1402