Fusion of a cell penetrating peptide from HIV-1 TAT to the Theileria parva antigen Tp2 enhances the stimulation of bovine CD8+ T cell responses

Veterinary Immunology and Immunopathology

Volumn 130, Issue 1-2, 2009, Pages 107-113

  Tinega, Alex N ^a,b   Pellé, Roger ^a   Kang'a, Simon ^c   Gicheru, Michael M ^b   Taracha, Evans L N ^a   Nene, Vishvanath ^c   Graham, Simon P ^a  

^a INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

^b KENYATTA UNIVERSITY   (Kenya)

^c J CRAIG VENTER INSTITUTE   (United States)

Author keywords

CD8+ T cells; Cell penetrating peptide; Protein; Theileria parva

Indexed keywords

CD8 ANTIGEN; CELL PENETRATING PEPTIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PARASITE ANTIGEN; RECOMBINANT PROTEIN; THEILERIA PARVA ANTIGEN 2; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; COW; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE IMMUNITY; T LYMPHOCYTE ACTIVATION; THEILERIA PARVA;

ANIMALS; ANTIGENS, PROTOZOAN; CATTLE; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTERFERON-GAMMA; RECOMBINANT FUSION PROTEINS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; THEILERIA PARVA; THEILERIASIS;

ANIMALIA; BOVINAE; HUMAN IMMUNODEFICIENCY VIRUS 1; THEILERIA PARVA;

EID: 67349116815     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2009.01.008     Document Type: Article

References (28)

1. Barry M., and Bleackley R.C. Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2 (2002) 401-409
2. Fawell S., Seery J., Daikh Y., Moore C., Chen L.L., Pepinsky B., and Barsoum J. Tat-mediated delivery of heterologous proteins into cells. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 664-668
3. Frankel A.D., and Pabo C.O. Cellular uptake of the TAT protein from human immunodeficiency virus. Cell 55 (1988) 1189-1193
4. Gariepy J., and Kawamura K. Vectorial delivery of macromolecules into cells using peptide-based vehicles. Trends Biotechnol. 19 (2001) 21-28
5. Goddeeris B.M., and Morrison W.I. Techniques for the generation, cloning and characterization of bovine cytotoxic T cells specific for the protozoan Theileria parva. J. Tissue Cult. Methods 11 (1988) 101-110
6. Goddeeris B.M., Morrison W.I., Toye P.G., and Bishop R. Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC. Immunology 69 (1990) 38-44
7. Graham S.P., Pellé R., Honda Y., Mwangi D.M., Tonukari N.J., Yamage M., Glew E.J., Bishop R., de Villiers E.P., Shah T., Abuya E., Awino E., Gachanja J., Luyai A.E., Mbwika F., Muthiani A.M., Ndegwa D.M., Njahira M., Nyanjui J.K., Onono F.O., Osaso J., Saya R.M., Wildmann C., Fraser C.M., Maudlin I., Gardner M.J., Morzaria S.P., Loosmore S., Gilbert S.C., Audonnet J.C., van der Bruggen P., Nene V., and Taracha E.L.N. Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 3286-3291
8. Graham S.P., Honda Y., Pellé R., Mwangi D.M., Glew E.J., de Villiers E.P., Shah T., Bishop R., van der Bruggen P., Nene V., and Taracha E.L.N. A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology. Immunome Res. 3 (2007) 2
9. Graham S.P., Pellé R., Yamage M., Mwangi D.M., Honda Y., Mwakubambanya R.S., de Villiers E.P., Abuya E., Awino E., Gachanja J., Mbwika F., Muthiani A.M., Muriuki C., Nyanjui J.K., Onono F.O., Osaso J., Riitho V., Saya R.M., Ellis S.A., McKeever D.J., Machugh N.D., Gilbert S.C., Audonnet J.C., Morrison W.I., van der Bruggen P., and Taracha E.L.N. Characterization of the fine specificity of bovine CD8 T cell responses to defined antigens from the protozoan parasite Theileria parva. Infect. Immun. 76 (2008) 685-694
10. Ivanov A.I. Pharmacological inhibition of endocytic pathways: is it specific enough to be useful?. In: Ivanov A.I. (Ed). Exocytosis and Endocytosis Series: Methods in Molecular Biology vol. 440 (2008), Humana Press, Totowa, NJ 15-36
11. Jenne L., Schuler G., and Steinkasserer A. Viral vectors for dendritic cell-based immunotherapy. Trends Immunol. 22 (2001) 102
12. Kim D.T., Mitchell D.J., Brockstedt D.G., Fong L., Nolan G.P., Fathman C.G., Engleman E.G., and Rothbard J.B. Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide. J. Immunol. 159 (1997) 1666-1668
13. Laus R., Graddis T.J., Hakim I., and Vidovic D. Enhanced major histocompatibility complex class I-dependent presentation of antigens modified with cationic and fusogenic peptides. Nat. Biotechnol. 18 (2000) 1269-1272
14. Lindgren M., Hällbrink M., Prochiantz A., and Langel U. Cell-penetrating peptides. Trends Pharmacol. Sci. 21 (2000) 99-103
15. Mann D.A., and Frankel A.D. Endocytosis and targeting of exogenous HIV-1 Tat protein. EMBO J. 10 (1991) 1733-1739
16. McKeever D.J., Awino E., and Morrison W.I. Afferent lymph veiled cells prime CD4+ T cell responses in vivo. Eur. J. Immunol. 22 (1992) 3057-3061
17. + fraction of responding efferent lymph. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 1959-1963
18. Pellé R., McOdimba F., Chuma F., Wasawo D., Pearson T.W., and Murphy N.B. The African trypanosome cyclophilin A homologue contains unusual conserved central and N-terminal domains and is developmentally regulated. Gene 290 (2002) 181-191
19. Pooga M., Kut C., and Kihlmark M. Cellular translocation of proteins by transportan. FASEB J. 15 (2001) 1451-1453
20. Rock K.L., Gramm C., Rothstein L., Clark K., Stein R., Dick L., Hwang D., and Goldberg A.L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78 (1994) 761-771
21. Sampath P., and Pollard T.D. Effects of cytochalasin, phalloidin, and pH on the elongation of actin filaments. Biochemistry 30 (1991) 1973-1980
22. Schwarze S.R., Ho A., Vocero-Akbani A., and Dowdy S.F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285 (1999) 1569-1572
23. Shibagaki N., and Udey M.C. Dendritic cells transduced with TAT protein transduction domain-containing tyrosinase-related protein 2 vaccinate against murine melanoma. Eur. J. Immunol. 33 (2003) 850-860
24. Stephens D.J., and Pepperkok R. The many ways to cross the plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 4295-4298
25. Tanaka Y., Dowdy S.F., Linehan D.C., Eberlein T.J., and Goedegebuure P.S. Induction of antigen-specific CTL by recombinant HIV trans-activating fusion protein-pulsed human monocyte-derived dendritic cells. J. Immunol. 170 (2003) 1291-1298
26. Taracha E.L.N., Goddeeris B.M., Morzaria S.P., and Morrison W.I. Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva. Infect. Immun. 63 (1995) 1258-1262
27. Wadia J.S., and Dowdy S.F. Protein transduction technology. Curr. Opin. Biotechnol. 13 (2002) 52-56
28. Yewdell J.W., and Bennink J.R. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science 244 (1989) 1072-1075