NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells

Clinical and Experimental Metastasis

Volumn 26, Issue 5, 2009, Pages 447-456

  Kubota, Takeshi ^a   Taiyoh, Hiroaki ^a   Matsumura, Atsushi ^a   Murayama, Yasutoshi ^a   Ichikawa, Daisuke ^a   Okamoto, Kazuma ^a   Fujiwara, Hitoshi ^a   Ikoma, Hisashi ^a   Nakanishi, Masayoshi ^a   Kikuchi, Shojiro ^a   Sakakura, Chouhei ^a   Ochiai, Toshiya ^a   Kokuba, Yukihito ^a   Taniguchi, Hiroki ^a   Sonoyama, Teruhisa ^a   Matsumoto, Kunio ^b   Nakamura, Toshikazu ^c   Otsuji, Eigo ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

C Met; CT26; Endothelial cell; FAK; HGF; NK4; Pulmonary metastasis

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIMETASTATIC AGENT; FOCAL ADHESION KINASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN NK 4; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOIKIS; ARTICLE; CELL ADHESION; CELL CULTURE; CELL INTERACTION; CELL LINE; CELL LINE CT 26; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC TRANSFECTION; HUMAN; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL ADHESION; CELL COMMUNICATION; CELL LINE, TUMOR; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; FEMALE; HEPATOCYTE GROWTH FACTOR; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; SIGNAL TRANSDUCTION;

EID: 67349115229     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-009-9244-0     Document Type: Article

References (40)

1. T Nakamura T Nishizawa M Hagiya 1989 Molecular cloning and expression of human hepatocyte growth factor Nature 342 440 443 10.1038/342440a0
2. K Miyazawa H Tsubouchi D Naka 1989 Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor Biochem Biophys Res Commun 163 967 973 10.1016/0006-291X(89)92316-4
3. C Birchmeier W Birchmeier E Gherardi GF Vande Woude 2003 Met, metastasis, motility and more Nat Rev Mol Cell Biol 4 915 925 10.1038/nrm1261
4. WG Jiang TA Martin C Parr G Davies K Matsumoto T Nakamura 2005 Hepatocyte growth factor, its receptor, and their potential value in cancer therapies Crit Rev Oncol Hematol 53 35 69 10.1016/j.critrevonc.2004.09.004
5. K Matsumoto T Nakamura 1996 Emerging multipotent aspects of hepatocyte growth factor J Biochem 119 591 600 (Pubitemid 26131762)
6. K Fazekas O Csuka I Koves E Raso J Timar 2000 Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis Clin Exp Metastasis 18 639 649 10.1023/A:1013136303880
7. JM Otte F Schmitz K Kiehne 2000 Functional expression of HGF and its receptor in human colorectal cancer Digestion 61 237 246 10.1159/000007764 (Pubitemid 30418224)
8. K Date K Matsumoto H Shimura M Tanaka T Nakamura 1997 HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor FEBS Lett 420 1 6 10.1016/S0014-5793(97)01475-0
9. K Kuba K Matsumoto K Date H Shimura M Tanaka T Nakamura 2000 HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice Cancer Res 60 6737 6743
10. K Matsumoto T Nakamura 2005 Mechanism and significance of bifunctional NK4 in cancer treatment Biochem Biophys Res Commun 333 316 327 10.1016/j.bbrc.2005.05.131
11. H Fujiwara T Kubota H Amaike 2005 Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression Cancer Gene Ther 12 206 216 10.1038/sj.cgt.7700782
12. M Yoshimura H Fujiwara T Kubota 2005 Possible inhibition of cancer cell adhesion to the extracellular matrix in NK4-induced suppression of peritoneal implantation Anticancer Res 25 3847 3854 (Pubitemid 41665154)
13. T Kubota H Fujiwara H Amaike 2004 Reduced HGF expression in subcutaneous CT26 tumor genetically modified to secrete NK4 and its possible relation with antitumor effects Cancer Sci 95 321 327 10.1111/j.1349-7006.2004.tb03210.x
14. T Kushibiki K Matsumoto T Nakamura Y Tabata 2004 Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin Gene Ther 11 1205 1214 10.1038/sj.gt.3302285
15. M Saimura E Nagai K Mizumoto 2002 Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4 Clin Cancer Res 8 3243 3249 (Pubitemid 35155037)
16. EB Voura M Sandig CH Siu 1998 Cell-cell interactions during transendothelial migration of tumor cells Microsc Res Tech 43 265 275 10.1002/(SICI)1097-0029(19981101)43:3<265::AID-JEMT9>3.0.CO;2-Z
17. KV Honn DG Tang 1992 Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix Cancer Metastasis Rev 11 353 375 10.1007/BF01307187
18. RO Hynes 1992 Integrins: versatility, modulation, and signaling in cell adhesion Cell 69 11 25 10.1016/0092-8674(92)90115-S
19. EA Price DR Coombe JC Murray 1996 Beta-1 integrins mediate tumour cell adhesion to quiescent endothelial cells in vitro Br J Cancer 74 1762 1766 (Pubitemid 26401896)
20. IS Weimar D de Jong EJ Muller 1997 Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via alpha 4 beta 1 and alpha 5 beta 1 integrins Blood 89 990 1000
21. L Trusolino S Cavassa P Angelini 2000 HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity FASEB J 14 1629 1640 10.1096/fj.14.11.1629 (Pubitemid 30636566)
22. DJ Sieg CR Hauck DD Schlaepfer 1999 Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration J Cell Sci 112 2677 2691 (Pubitemid 29429791)
23. K Matsumoto K Matsumoto T Nakamura R Kramer 1994 Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125 FAK) and promotes migration and invasion by oral squamous cell carcinoma cells J Biol Chem 269 31807 31813 (Pubitemid 24379552)
24. HC Chen PC Chan MJ Tang CH Cheng TJ Chang 1998 Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation J Biol Chem 273 25777 25782 10.1074/jbc.273.40.25777
25. S Van Slambrouck C Grijelmo O De Wever 2007 Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion Int J Oncol 31 1501 1508
26. G von Wichert D Krndija H Schmid 2008 Focal adhesion kinase mediates defects in the force-dependent reinforcement of initial integrin-cytoskeleton linkages in metastatic colon cancer cell lines Eur J Cell Biol 87 1 16 10.1016/j.ejcb.2007.07.008
27. K Toda K Tsujioka Y Maruguchi 1990 Establishment and characterization of a tumorigenic murine vascular endothelial cell line (F-2) Cancer Res 50 5526 5530 (Pubitemid 20303014)
28. SM Frisch RA Screaton 2001 Anoikis mechanisms Curr Opin Cell Biol 13 555 562 10.1016/S0955-0674(00)00251-9
29. AF Chambers IC MacDonald EE Schmidt 1995 Steps in tumor metastasis: new concepts from intravital videomicroscopy Cancer Metastasis Rev 14 279 301 10.1007/BF00690599
30. IJ Fidler 1990 Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture Cancer Res 50 6130 6138 (Pubitemid 20323663)
31. F Bussolino MF Di Renzo M Ziche 1992 Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth J Cell Biol 119 629 641 10.1083/jcb.119.3.629
32. G Davies WG Jiang MD Mason 2001 Matrilysin mediates extracellular cleavage of E-Cadherin from prostate cancer cells. A key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion Clin Cancer Res 7 3289 3297 (Pubitemid 32963856)
33. Y Nakamura D Matsubara A Goto 2008 Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines Cancer Sci 99 14 22 10.1111/j.1349-7006.2008. 00838.x (Pubitemid 350239026)
34. EA Clark JS Brugge 1995 Integrins and signal transduction pathways: the road taken Science 268 233 239 10.1126/science.7716514
35. L Beviglia RH Kramer 1999 HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells Int J Cancer 83 640 649 10.1002/(SICI)1097-0215(19991126)83:5<640::AID-IJC13>3.0.CO;2-D
36. G Maulik T Kijima PC Ma 2002 Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer Clin Cancer Res 8 620 627 (Pubitemid 34193985)
37. V Thamilsevan DH Craig MD Basson 2007 FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway FASEB J 21 1730 1741 10.1096/fj.06-6545com
38. SM Frisch H Francis 1994 Disruption of epithelial cell-matrix interactions induces apoptosis J Cell Biol 124 619 626 10.1083/jcb.124.4.619 (Pubitemid 24064472)
39. Y Zhang H Lu P Dazin Y Kapila 2004 Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase J Biol Chem 279 48342 48349 10.1074/jbc.M407953200
40. S Kanayama Y Yamada R Kawaguchi Y Tsuji S Haruta H Kobayashi 2008 Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells Oncol Rep 19 117 122