Capillary injury in the ischemic brain of hyperlipidemic, apolipoprotein B-100 transgenic mice

Life Sciences

Volumn 84, Issue 25-26, 2009, Pages 935-939

  Süle, Zoltán ^a   Mracskó, Éva ^b   Bereczki, Erika ^c   Sántha, Miklós ^c   Csont, Tamás ^d,e   Ferdinandy, Péter ^d,e   Bari, Ferenc ^b   Farkas, Eszter ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c INSTITUTE OF BIOCHEMISTRY   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

^e PHARMAHUNGARY GROUP   (Hungary)

Author keywords

Apolipoprotein; Atherosclerosis; Brain; Cholesterol; Hyperlipidemia; Ischemia; Microvascular; Transgenic mouse; Unilateral carotid occlusion

Indexed keywords

APOLIPOPROTEIN B100;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD VESSEL DIAMETER; BRAIN CAPILLARY; BRAIN ISCHEMIA; CAPILLARY DENSITY; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR DISEASE; CHOLESTEROL DIET; COMMON CAROTID ARTERY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GENE OVEREXPRESSION; HYPERLIPIDEMIA; MALE; MICROANGIOPATHY; MICROVILLUS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; APOLIPOPROTEIN B-100; BRAIN; BRAIN ISCHEMIA; CAPILLARIES; CHOLESTEROL, DIETARY; FEMALE; GENE EXPRESSION; HUMANS; HYPERLIPIDEMIAS; LIPIDS; MALE; MICE; MICE, TRANSGENIC;

MUS; MUS MUSCULUS;

EID: 67349109736     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.04.011     Document Type: Article

References (38)

1. Amarenco P., Röther J., Michel P., Davis S.M., and Donnan G.A. Aortic arch atheroma and the risk of stroke. Current Atherosclerosis Reports 8 4 (2006) 343-346
2. Bereczki E., Bernát G., Csont T., Ferdinándy P., Scheich H., and Sántha M. Overexpression of human apolipoprotein B-100 induces severe neurodegeneration in transgenic mice. Journal of Proteome Research 7 6 (2008) 2246-2252
3. Bjelik A., Pákáski M., Bereczki E., Gonda S., Juhász A., Rimanóczy Á., Zana M., Janka Z., Sántha M., and Kálmán J. APP mRNA splicing is upregulated in the brain of biglycan transgenic mice. Neurochemistry International 50 1 (2007) 1-4
4. Blasiole D.A., Davis R.A., and Attie A.D. The physiological and molecular regulation of lipoprotein assembly and secretion. Molecular Biosystems 3 9 (2007) 608-619
5. Chiesa G., Johnson D.F., Yao Z., Innerarity T.L., Mahley R.W., Young S.G., Hammer R.H., and Hobbs H.H. Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA. The Journal of Biological Chemistry 268 32 (1993) 23747-23750
6. Csete K., Kovács G.L., and Szekeres L. Disturbance of motoric function as behavioral measure of impaired cerebral circulation in mice. Physiology and Behavior 36 3 (1986) 409-412
7. Csont T., Bereczki E., Bencsik P., Fodor G., Görbe A., Zvara A., Csonka C., Puskás L.G., Sántha M., and Ferdinandy P. Hypercholesterolemia increases myocardial oxidative and nitrosative stress thereby leading to cardiac dysfunction in apoB-100 transgenic mice. Cardiovascular Research 76 1 (2007) 100-109
8. Demchuk A.M., Hess D.C., Brass L.M., and Yatsu F.M. Is cholesterol a risk factor for stroke? Yes. Archives of Neurology 56 12 (1999) 1518-1520
9. Dietrich W.D., Ginsberg M.D., Busto R., Watson B.D., and Yoshida S. Vascular aspects and hemodynamic consequences of central nervous system injury. Central Nervous System Trauma 3 4 (1986) 265-280
10. Dore-Duffy P., and LaManna J.C. Physiologic angiodynamics in the brain. Antioxidants and Redox Signaling 9 9 (2007) 1363-1371
11. Farkas E., Süle Z., Tóth-Szu{double acute}ki V., Mátyás A., Antal P., Farkas I.G., Mihály A., and Bari F. Tumor necrosis factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric oxide in the rat brain. Microvascular Research 72 3 (2006) 113-119
12. Franklin K.B.J., and Paxinos G. The mouse brain in stereotaxic coordinates (1997), Academic Press, San Diego
13. Goldstein L.B. Statins for stroke prevention. Current Atherosclerosis Reports 9 4 (2007) 305-311
14. Grundy S.M., Vega G.L., and Kesäniemi Y.A. Abnormalities in metabolism of low density lipoproteins associated with coronary heart disease. Acta Medica Scandinavica. Supplementum 701 (1985) 23-37
15. Haseloff R.F., Blasig I.E., Bauer H.C., and Bauer H. In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro. Cellular and Molecular Neurobiology 25 1 (2005) 25-39
16. Ishikawa M., Stokes K.Y., Zhang J.H., Nanda A., and Granger D.N. Cerebral microvascular responses to hypercholesterolemia: roles of NADPH oxidase and P-selectin. Circulation Research 94 2 (2004) 239-244
17. Jang J.J., Ho H.K., Kwan H.H., Fajardo L.F., and Cooke J.P. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 102 12 (2000) 1414-1419
18. Kitagawa K., Matsumoto M., Yang G., Mabuchi T., Yagita Y., Hori M., and Yanagihara T. Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: evaluation of the patency of the posterior communicating artery. Journal of Cerebral Blood Flow and Metabolism 18 (1998) 570-579
19. Landau W.M. Is cholesterol a risk factor for stroke? No. Archives of Neurology 56 12 (1999) 1521-1524
20. Lee E.Y., Lee S.Y., Lee T.S., Chi J.G., Choi W., and Suh Y.H. Ultrastructural changes in microvessel with age in the hippocampus of senescence-accelerated mouse (SAM)-P/10. Experimental Aging Research 26 1 (2000) 3-14
21. Libby P. Fat fuels the flame: triglyceride-rich lipoproteins and arterial inflammation. Circulation Research 100 3 (2007) 299-301
22. Linton M.F., Farese R.V., Chiesa G., Grass D.S., Chin P., Hammer R.E., Hobbs H.H., and Young S.G. Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a). Journal of Clinical Investigation 92 6 (1993) 3029-3037
23. Mooradian A.D., Lung C.C., and Pinnas J.L. Cholesterol enriched diet enhances malondialdehyde modification of proteins in cerebral microvessels of rabbits. Neuroscience Letters 185 3 (1995) 211-213
24. Naganuma Y. Changes of the cerebral microvascular structure and endothelium during the course of permanent ischemia. The Keio Journal of Medicine 39 1 (1990) 26-31
25. Olofsson S.O., and Borèn J. Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis. Journal of Internal Medicine 258 5 (2005) 395-410
26. Persson J., Nilsson J., and Lindholm M.W. Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages. Lipids in Health and Disease 5 (2006) 17
27. Plaschke K., Staub J., Ernst E., and Marti H.H. VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion. Experimental Neurology 214 2 (2008) 285-292
28. Plate K.H. Mechanisms of angiogenesis in the brain. Journal of Neuropathology and Experimental Neurology 58 4 (1999) 313-320
29. Purcell-Huynh D.A., Farese R.V., Johnson D.F., Flynn L.M., Pierotti V., Newland D.L., Linton M.F., Sanan D.A., and Young S.G. Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. Journal of Clinical Investigation 95 5 (1995) 2246-2257
30. Robert A.M., Miskulin M., Godeau G., Tixier J.M., and Milhaud G. Action of calcitonin on the atherosclerotic modifications of brain microvessels induced in rabbits by cholesterol feeding. Experimental and Molecular Pathology 37 1 (1982) 67-73
31. Rudel L.L., Parks J.S., Johnson F.L., and Babiak J. Low density lipoproteins in atherosclerosis. Journal of Lipid Research 27 5 (1986) 465-474
32. Sasaki N., Saito Y., and Yosida S. Effect of hypercholesterolemia on cholinephosphotransferase activity in rabbit and rat vessel walls. Atherosclerosis 74 3 (1988) 241-246
33. Shahar E., Chambless L.E., Rosamond W.D., Boland L.L., Ballantyne C.M., McGovern P.G., Sharrett A.R., and Atherosclerosis Risk in Communities Study. Plasma lipid profile and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke 34 3 (2003) 623-631
34. Sharifkazemi M.B., Aslani A., Zamirian M., and Moaref A.R. Significance of aortic atheroma in elderly patients with ischemic stroke. A hospital-based study and literature review. Clinical Neurology and Neurosurgery 109 4 (2007) 311-316
35. Sherman, D.G., The carotid artery and stroke. American Family Physician 40(5 Suppl), 41S-44S, 47S-49S, 1989.
36. Ueno M., Akiguchi I., Hosokawa M., Shinnou M., Sakamoto H., Takemura M., and Higuchi K. Ultrastructural and permeability features of microvessels in the olfactory bulbs of SAM mice. Acta Neuropathologica (Berlin) 96 3 (1998) 261-270
37. Van Belle E., Rivard A., Chen D., Silver M., Bunting S., Ferrara N., Symes J.F., Bauters C., and Isner J.M. Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation 96 8 (1997) 2667-2674
38. Yoshizaki K., Adachi K., Kataoka S., Watanabe A., Tabira T., Takahashi K., and Wakita H. Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice. Experimental Neurology 210 2 (2008) 585-591