Protein kinases C isozymes are differentially expressed in human breast carcinomas

Life Sciences

Volumn 84, Issue 21-22, 2009, Pages 766-771

  Ali, Shadan ^a   Al Sukhun, Sana ^a   El Rayes, Bassel F ^a   Sarkar, Fazlul H ^b   Heilbrun, Lance K ^a   Philip, Philip A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Her 2 neu; Protein kinase C

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ISOENZYME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA INHIBITOR; PROTEIN KINASE C EPSILON; TISSUE EXTRACT;

ARTICLE; BREAST CANCER; BREAST REDUCTION; CARCINOMA CELL; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CYTOSOL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PARTIAL MASTECTOMY; PROTEIN EXPRESSION; WESTERN BLOTTING; WILCOXON SIGNED RANKS TEST;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; PROTEIN KINASE C; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN;

EID: 67349101767     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.03.007     Document Type: Article

References (36)

1. Benz C.C., Scott G.K., Sarup J.C., Johnson R.M., Tripathy D., Coronado E., Shepard H.M., and Osborne C.K. Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu. Breast Cancer Research and Treatment 24 2 (1992) 85-95
2. Blobe G.C., Obeid L.M., and Hannun Y.A. Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Reviews 13 3-4 (1994) 411-431
3. Borner C., Ueffing M., Jaken S., Parker P.J., and Weinstein I.B. Two closely related isoforms of protein kinase C produce reciprocal effects on the growth of rat fibroblasts. Possible molecular mechanisms. Journal of Biological Chemistry 270 1 (1995) 78-86
4. Cho Y., Tighe A.P., and Talmage D.A. Retinoic acid induced growth arrest of human breast carcinoma cells requires protein kinase C alpha expression and activity. Journal of Cellular Physiology 172 3 (1997) 306-313
5. Deacon E.M., Pongracz J., Griffiths G., and Lord J.M. Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. Molecular Pathology 50 3 (1997) 124-131
6. Dekker L.V., and Parker P.J. Protein kinase C-a question of specificity. Trends in Biochemical Sciences 19 2 (1994) 73-77
7. Dem P., Favre G., and Poirot M. Multiple targeting by the antitumor drug tamoxifen: a structure-activity study. Current Medical Chemistry Anticancer Agents 4 6 (2004) 491-508
8. El-Rayes B.F., Ali S., Philip P.A., and Sarkar F.H. Protein kinase C: a target for therapy in pancreatic cancer. Pancreas 36 4 (2008) 346-352
9. Engers R., Mrzyk S., Springer E., Fabbro D., Weissgerber G., Gernharz C.D., and Gabbert H.E. Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression. British Journal of Cancer 82 5 (2000) 1063-1069
10. Esparis-Ogando A., Az-Rodriguez E., and Pandiella A. Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and phosphatidylinositol 3-kinase. Biochemical Journal 344 Pt 2 (1999) 339-348
11. Gruvberger S., Ringner M., Chen Y., Panavally S., Saal L.H., Borg A., Ferno M., Peterson C., and Meltzer P.S. Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Research 61 16 (2001) 5979-5984
12. Gusterson B.A., Gelber R.D., Goldhirsch A., Price K.N., Save-Soderborgh J., Anbazhagan R., Styles J., Rudenstam C.M., Golouh R., and Reed R. Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. Journal of Clinical Oncology 10 7 (1992) 1049-1056
13. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 6 (1979) 65-70
14. Jaken S. Protein kinase C isozymes and substrates. Current Opinion in Cell Biology 8 2 (1996) 168-173
15. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., and Thun M.J. Cancer statistics, 2008. CA Cancer Journal for Clinicians 58 2 (2008) 71-96
16. Kazanietz M.G. Protein kinase C and novel receptors for the phorbol esters and the second messenger diacylglycerol. Medicina (B Aires) 60 5 Pt 2 (2000) 685-688
17. Le X.F., Marcelli M., McWatters A., Nan B., Mills G.B., O'Brian C.A., and Bast Jr. R.C. Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity. Oncogene 20 57 (2001) 8258-8269
18. Mackay H.J., and Twelves C.J. Protein kinase C: a target for anticancer drugs?. Endocrine-Related Cancer 10 3 (2003) 389-396
19. Manni A., Buckwalter E., Etindi R., Kunselman S., Rossini A., Mauger D., Dabbs D., and Demers L. Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression. Cell Growth and Differentiation 7 9 (1996) 1187-1198
20. Mischak H., Goodnight J.A., Kolch W., Martiny-Baron G., Schaechtle C., Kazanietz M.G., Blumberg P.M., Pierce J.H., and Mushinski J.F. Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. Journal of Biological Chemistry 268 9 (1993) 6090-6096
21. Morse-Gaudio M., Connolly J.M., and Rose D.P. Protein kinase C and its isoforms in human breast cancer cells: relationship to the invasive phenotype. International Journal of Oncology 12 6 (1998) 1349-1354
22. Murray N.R., Baumgardner G.P., Burns D.J., and Fields A.P. Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation. Evidence that beta II protein kinase C is required for proliferation. Journal of Biological Chemistry 268 21 (1993) 15847-15853
23. Osborne C.K. Steroid hormone receptors in breast cancer management. Breast Cancer Research and Treatment 51 3 (1998) 227-238
24. Paik S., Hazan R., Fisher E.R., Sass R.E., Fisher B., Redmond C., Schlessinger J., Lippman M.E., and King C.R. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. Journal of Clinical Oncology 8 1 (1990) 103-112
25. Philip P.A., and Zonder J.A. Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug. Expert Opinion on Investigational Drugs 8 12 (1999) 2189-2199
26. Ron D., and Kazanietz M.G. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB Journal 13 13 (1999) 1658-1676
27. Sauma S., Yan Z., Ohno S., and Friedman E. Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. Cell Growth and Differentiation 7 5 (1996) 587-594
28. Slaughter D.P., Southwick H.W., and Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6 5 (1953) 963-968
29. Sliva D., English D., Lyons D., and Lloyd Jr. F.P. Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB. Biochemical and Biophysical Research Communications 290 1 (2002) 552-557
30. Sprent P., and Smeeton N.C. Applied nonparametric statistical methods vol. 1 (1993), Chapman and Hall
31. Stranzl A., Schmidt H., Winkler R., and Kostner G.M. Low-density lipoprotein receptor mRNA in human breast cancer cells: influence by PKC modulators. Breast Cancer Research and Treatment 42 3 (1997) 195-205
32. Svensson K., Zeidman R., Troller U., Schultz A., and Larsson C. Protein kinase C beta1 is implicated in the regulation of neuroblastoma cell growth and proliferation. Cell Growth and Differentiation 11 12 (2000) 641-648
33. Ways D.K., Kukoly C.A., Devente J., Hooker J.L., Bryant W.O., Posekany K.J., Fletcher D.J., Cook P.P., and Parker P.J. MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. Journal of Clinical Investigation 95 4 (1995) 1906-1915
34. Williams C.L., and Noti J.D. Reduced expression of Wnt-1 and E-cadherin, and diminished beta-catenin stability in MCF-7 breast cancer cells that overexpress protein kinase C-alpha. International Journal of Oncology 19 6 (2001) 1227-1233
35. Yamamoto M., Patel N.A., Taggart J., Sridhar R., and Cooper D.R. A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-betaII. International Journal of Cancer 83 1 (1999) 98-106
36. Yao J., Xiong S., Klos K., Nguyen N., Grijalva R., Li P., and Yu D. Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene 20 56 (2001) 8066-8074