Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 3, 2009, Pages 473-483

  Hanada, Mitsuharu ^a   Baba, Akemi ^a   Tsutsumishita, Yasuyuki ^a   Noguchi, Toshihiro ^a   Yamaoka, Takashi ^a   Chiba, Nobuyoshi ^a   Nishikaku, Fumio ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Apoptosis; Hepatocellular carcinoma; Lipiodol; Miriplatin; Platinum DNA adducts

Indexed keywords

CISPLATIN; DICHLORO (1,2 CYCLOHEXANEDIAMINE N,N')PLATINUM; DNA; IODINATED POPPYSEED OIL; MIRIPLATIN; PLATINUM COMPLEX; SM 11355; UNCLASSIFIED DRUG; ZINOSTATIN MALEIC ACID STYRENE COPOLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GRAFT; CANCER INHIBITION; CHEMOEMBOLIZATION; CONTROLLED STUDY; DNA ADDUCT; DRUG DISPOSITION; DRUG RELEASE; DRUG TISSUE LEVEL; HEPATIC ARTERY; LIVER CANCER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CHEMOEMBOLIZATION, THERAPEUTIC; CISPLATIN; DELAYED-ACTION PREPARATIONS; DNA ADDUCTS; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; HEPATIC ARTERY; INFUSIONS, INTRA-ARTERIAL; IODIZED OIL; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOGRAPHY; MALE; NEOPLASM TRANSPLANTATION; ORGANOPLATINUM COMPOUNDS; RATS;

EID: 67349098189     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0895-3     Document Type: Article

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