Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children

Clinical Immunology

Volumn 131, Issue 3, 2009, Pages 410-414

  Ruel, Theodore ^a   Ssewanyana, Isaac ^b   Achan, Jane ^c   Gasasira, Anne ^d   Kamya, Moses R ^c   Kekitiinwa, Adeodata ^e   Wong, Joseph K ^a   Cao, Huyen ^f   Havlir, Diane ^a   Charlebois, Edwin D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOINT CLINICAL RESEARCH CENTRE   (Uganda)

^c MAKERERE UNIVERSITY   (Uganda)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MULAGO HOSPITAL   (Uganda)

^f CALIFORNIA DEPARTMENT OF PUBLIC HEALTH   (United States)

Author keywords

Antiretroviral treatment; Children; T cell activation; Uganda

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; CD4 ANTIGEN; EFAVIRENZ; HLA DR ANTIGEN; LAMIVUDINE; NEVIRAPINE; STAVUDINE; VIRUS RNA; ZIDOVUDINE;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; UGANDA;

ANTI-HIV AGENTS; ANTIGENS, CD38; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; HIV INFECTIONS; HLA-DR ANTIGENS; HUMANS; INFANT; LYMPHOCYTE ACTIVATION; UGANDA;

EID: 67349089235     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.01.016     Document Type: Article

References (21)

1. Plaeger-Marshall S., Isacescu V., O'Rourke S., Bertolli J., Bryson Y.J., and Stiehm E.R. T cell activation in pediatric AIDS pathogenesis: three-color immunophenotyping. Clin. Immunol. Immunopathol. 71 (1994) 19-26
2. Douek D.C., McFarland R.D., Keiser P.H., Gage E.A., Massey J.M., Haynes B.F., Polis M.A., Haase A.T., Feinberg M.B., Sullivan J.L., Jamieson B.D., Zack J.A., Picker L.J., and Koup R.A. Changes in thymic function with age and during the treatment of HIV infection. Nature 396 (1998) 690-695
3. Paul M.E., Shearer W.T., Kozinetz C.A., and Lewis D.E. Comparison of CD8+ T-cell subsets in HIV-infected rapid progressor children versus non-rapid progressor children. J. Allergy Clin. Immunol. 108 (2001) 258-264
4. Paul M.E., Mao C., Charurat M., Serchuck L., Foca M., Hayani K., Handelsman E.L., Diaz C., McIntosh K., and Shearer W.T. Predictors of immunologic long-term nonprogression in HIV-infected children: implications for initiating therapy. J. Allergy Clin. Immunol. 115 (2005) 848-855
5. Deeks S.G., Kitchen C.M., Liu L., Guo H., Gascon R., Narvaez A.B., Hunt P., Martin J.N., Kahn J.O., Levy J., McGrath M.S., and Hecht F.M. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 104 (2004) 942-947
6. Hunt P.W., Martin J.N., Sinclair E., Bredt B., Hagos E., Lampiris H., and Deeks S.G. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J. Infect. Dis. 187 (2003) 1534-1543
7. Resino S.E., Gutierrez M.D., Leon J.A., and Munoz Fernandez M.A. CD4+ T-cell immunodeficiency is more dependent on immune activation than viral load in HIV-infected children on highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 42 (2006) 269-276
8. Rizzardini G., Trabattoni D., Saresella M., Piconi S., Lukwiya M., Declich S., Fabiani M., Ferrante P., and Clerici M. Immune activation in HIV-infected African individuals. Italian-Ugandan AIDS cooperation program. AIDS 12 (1998) 2387-2396
9. Baker C.A., Emenyonu N., Ssewanyana I., Jones N.G., Elrefaei M., Nghania F., Nakiwala J., Andia I., Clark R., Martin J., Bangsberg D.R., and Cao H. Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy. AIDS Res. Hum. Retrovir. 23 (2007) 900-905
10. Ondoa P., Koblavi-Deme S., Borget M.Y., Nolan M.L., Nkengasong J.N., and Kestens L. Assessment of CD8 T cell immune activation markers to monitor response to antiretroviral therapy among HIV-1 infected patients in Cote d'Ivoire. Clin. Exp. Immunol. 140 (2005) 138-148
11. Kamya M.R., Gasasira A.F., Achan J., Mebrahtu T., Ruel T., Kekitiinwa A., Charlebois E.D., Rosenthal P.J., Havlir D., and Dorsey G. Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS 21 (2007) 2059-2066
12. Ssewanyana I., Elrefaei M., Dorsey G., Ruel T., Jones N.G., Gasasira A., Kamya M., Nakiwala J., Achan J., Charlebois E., Havlir D., and Cao H. Profile of T cell immune responses in HIV-infected children from Uganda. J. Infect. Dis. 196 (2007) 1667-1670
13. WHO, Antiretroviral therapy of HIV infection in infants and children in resource-limited settings: towards universal access. (www.who.int/hiv/pub/guidelines/paediatric020907.pdf) (2006) 158.
14. Dorsey G., Staedke S., Clark T.D., Njama-Meya D., Nzarubara B., Maiteki-Sebuguzi C., Dokomajilar C., Kamya M.R., and Rosenthal P.J. Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA 297 (2007) 2210-2219
15. Eggena M.P., Barugahare B., Okello M., Mutyala S., Jones N., Ma Y., Kityo C., Mugyenyi P., and Cao H. T cell activation in HIV-seropositive Ugandans: differential associations with viral load, CD4+ T cell depletion, and coinfection. J. Infect. Dis. 191 (2005) 694-701
16. Liu Z., Hultin L.E., Cumberland W.G., Hultin P., Schmid I., Matud J.L., Detels R., and Giorgi J.V. Elevated relative fluorescence intensity of CD38 antigen expression on CD8+ T cells is a marker of poor prognosis in HIV infection: results of 6 years of follow-up. Cytometry 26 (1996) 1-7
17. Shearer W.T., Rosenblatt H.M., Gelman R.S., Oyomopito R., Plaeger S., Stiehm E.R., Wara D.W., Douglas S.D., Luzuriaga K., and McFarland E.J. Lymphocyte subsets in healthy children from birth through 18 years of age: the pediatric AIDS clinical trials group P1009 study. J. Allergy Clin. Immunol. 112 (2003) 973-980
18. Borkowsky W., Stanley K., Douglas S., Lee S., Wiznia A., Pelton S., Yogev R., McIntosh K., and Nachman S. Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected children. J. Infect. Dis. 182 (2000) 96-103
19. Rosenblatt H.M., Stanley K.E., Song L.Y., Johnson G.M., Wiznia A.A., Nachman S.A., and Krogstad P.A. Immunological response to highly active antiretroviral therapy in children with clinically stable HIV-1 infection. J. Infect. Dis. 192 (2005) 445-455
20. Clerici B.S., Lukwiya M., Saresella M., Declich S., Trabattoni D., Pastori C., Piconi S., Fracasso C., Fabiani M., Ferrante P., Rizzardini G., and Lopalco L. Immune activation in Africa is environmentally-driven and is associated with upregulation of CCR5. AIDS 14 (2000) 2083-2092
21. Kalinkovich A., Weisman Z., Greenberg Z., Nahmias J., Eitan S., Stein M., and Bentwich Z. Decreased CD4 and increased CD8 counts with T cell activation is associated with chronic helminth infection. Clin. Exp. Immunol. 114 (1998) 414-421