Is Persistent Ketamine Use a Valid Model of the Cognitive and Oculomotor Deficits in Schizophrenia?

Biological Psychiatry

Volumn 65, Issue 12, 2009, Pages 1099-1102

  Morgan, Celia J A ^a   Huddy, Vyv ^b   Lipton, Michelle ^b   Curran, H Valerie ^a   Joyce, Eileen M ^b,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antisaccades; drug abuse; eye tracking; ketamine; schizophrenia; smooth pursuit; spatial working memory; verbal memory

Indexed keywords

KETAMINE; NEUROLEPTIC AGENT;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE MODEL; DRUG MISUSE; DRUG SELF ADMINISTRATION; EYE MOVEMENT DISORDER; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MALE; MEMORY; MENTAL TASK; PRIORITY JOURNAL; RECREATION; SCHIZOPHRENIA; TASK PERFORMANCE; WORKING MEMORY;

ADOLESCENT; ADULT; COGNITION DISORDERS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; INTELLIGENCE TESTS; KETAMINE; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OCULAR MOTILITY DISORDERS; PSYCHOMOTOR PERFORMANCE; PURSUIT, SMOOTH; SCHIZOPHRENIC PSYCHOLOGY; SPACE PERCEPTION; SUBSTANCE-RELATED DISORDERS; VERBAL LEARNING; YOUNG ADULT;

EID: 67349088731     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.10.045     Document Type: Article

References (20)

1. Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., et al. Subanesthetic effects of the non-competitive NMDA-antagonist, ketamine, in humans. Arch Gen Psychiatry 51 (1994) 199-214
2. Luby E.D., Cohen B.D., Rosenbaum G., Gottlieb J.S., and Kelley R. Study of a new schizophrenomimetic drug-sernyl. Arch Neurol Psychiatry 81 (2002) 363-369
3. Morgan C.J.A., Mofeez A., Brandner B., Bromley L., and Curran H.V. Acute effects of ketamine on memory systems and psychotic symptoms in healthy volunteers. Neuropsychopharmacology 29 (2004) 208-218
4. Morgan C.J.A., Ricelli M., Maitland C.H., and Curran H.V. Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users. Drug Alcohol Depend 75 (2004) 301-308
5. Jentsch J.D., and Roth R.H. The neuropsychopharmacology of phencyclidine: From NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 30 (1999) 201-225
6. Turetsky B.I., Calkins M.E., Light G.A., Olincy A., Radant A.D., and Swerdlow N.R. Neurophysiological endophenotypes of schizophrenia: The viability of selected candidate measures. Schizophr Bull 33 (2007) 69-94
7. Hutton S.B., and Ettinger U. The antisaccade task as a research tool in psychopathology: A critical review. Psychophysiology 43 (2006) 302-313
8. Radant A.D., Bowdle T.A., Cowley D.S., Kharasch E.D., and Roy-Byrne P.P. Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities?. Neuropsychopharmacology 19 (1998) 434-444
9. Weiler M.A., Thaker G.K., Lahti A.C., and Tamminga C.A. Ketamine effects on eye movements. Neuropsychopharmacology 23 (2000) 645-653
10. Avila M.T., Weiler M.A., Lahti A.C., Tamminga C.A., and Thaker G.K. Effects of ketamine on leading saccades during smooth-pursuit eye movements may implicate cerebellar dysfunction in schizophrenia. Am J Psychiatry 159 (2002) 1490-1496
11. Solowij N., Hall W., and Lee N. Recreational MDMA use in Sydney: A profile of "Ecstasy" users and their experience with the drug. Br J Addiction 87 (1992) 1161-1172
12. Nelson H.E. The National Adult Reading Test (1982), NFER-Nelson, Windsor, United Kingdom
13. Huddy V.C., Hodgson T.L., Kapasi M., Mutsatsa S.H., Harrison I., Barnes T.R., and Joyce E.M. Gaze strategies during planning in first-episode psychosis. J Abnorm Psychol 116 (2007) 589-598
14. Rey A. L'Examen clinique en psychologie [Clinical tests in psychology] (1964), Presses Universitaires de France, Paris
15. Owen A.M., Downes J.J., Sahakian B.J., Polkey C.E., and Robbins T.W. Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28 (1990) 1021-1034
16. Thaker G.K., Ross D.E., Buchanan R.W., Moran M.J., Lahti A., Kim C., and Medoff D. Does pursuit abnormality in schizophrenia represent a deficit in the predictive mechanism?. Psychiatry Res 59 (1996) 221-237
17. Hutton S., Crawford T., Puri B., Duncan L., Chapman M., Kennard C., et al. Smooth pursuit and saccadic abnormalities in first-episode schizophrenia. Psychol Med 28 (1998) 685-692
18. Hutton S., Crawford T., Gibbins H., Cuthbert I., Barnes T., Kennard C., and Joyce E. Short and long term effects of antipsychotic medication on smooth pursuit eye tracking in schizophrenia. Psychopharmacology 157 (2001) 284-291
19. Mohamed S., Paulsen J., O'Leary D., and Andreasen N. Generalised cognitive deficits in schizophrenia: a study of first episode patients. Arch Gen Psychiatry 56 (1999) 749-754
20. Goldstein R.Z., and Volkow N.D. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry 159 (2002) 1642-1652