Intralesional bleomycin in the treatment of cutaneous warts: A randomized clinical trial comparing it with cryotherapy

Indian Journal of Dermatology, Venereology and Leprology

Volumn 75, Issue 3, 2009, Pages 262-267

  Dhar, S B ^a,b   Rashid, M M ^a   Islam, A Z M M ^a   Bhuiyan, M S I ^a  

^a BANGABANDHU SHEIKH MUJIB MEDICAL UNIVERSITY   (Bangladesh)

^b Bismillah Tower Kharam Para ^*  (Bangladesh)

Author keywords

Bleomycin; Cryotherapy; Intralesional; Wart

Indexed keywords

BLEOMYCIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYOTHERAPY; DEPIGMENTATION; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; TREATMENT DURATION; TREATMENT RESPONSE; VERRUCA VULGARIS;

ADOLESCENT; ADULT; BLEOMYCIN; CHILD; CHILD, PRESCHOOL; CRYOTHERAPY; FEMALE; HUMANS; INJECTIONS, INTRALESIONAL; MALE; MIDDLE AGED; TREATMENT OUTCOME; WARTS; YOUNG ADULT;

EID: 67249153063     PISSN: 03786323     EISSN: None     Source Type: Journal    
DOI: 10.4103/0378-6323.48428     Document Type: Article

References (32)

1. th ed. New York: McGraw-Hill; 2003. p. 2119-30, 2358,2575-80.
2. Bacelieri R, Johnson SM. Cutaneous wart: An evidence based approach to therapy. Am Fam Physician 2005;72:647-52.
3. th ed. Philadelphia: Saunders Elsevier; 2006. p. 403-15.
4. nd ed. Mumbai: Bhalani Publishing House; 2001. p. 303-9.
5. th ed. Massachuesttes: Blackwell Science; 2004. p. 25.39-57.
6. Sterling JC, Handfield-Jones S, Hudson PM. Guidelines for the management of cutaneous warts. Br J Dermatol 2001;144:4-11.
7. Gibbs S, Harvey I. Topical treatments for cutaneous warts. Cochrane Library. Issue 4. Chichester: John Wiley and Sons; 2007.
8. Gibbs S, Harvey I, Sterling J, Sterk R. Local treatments for cutaneous warts: Systemic review. BMJ 2002 325:461-7.
9. Thomas KS, Keogh-Brown MR, Chalmers JR, Fordham RJ, Holland RC, Armstrong SJ, et al. Effectiveness and cost-effectiveness of salicylic acid and cryotherapy for cutaneous warts: An economic decision model. Health Technol Assess 2006;10:9-87.
10. Hutchinson PE, Bleiker TO. Liquid nitrogen cryotherapy of common warts: Cryo-spray vs. cotton wool bud. Br J Dermatol 2002;146:1110.
11. Connolly M, Bazmi K, O'Connell M, Lyons J F, Bourke J F. Cryotherapy of viral warts: A sustained 10-s freeze is more effective than the traditional method. Br J Dermatol 2001;145:554-7.
12. Bourke J F, Berth-Jones J, Hutchinson PE. Cryotherapy of common viral warts at intervals of 1, 2 and 3 weeks. Br J Dermatol 1995 132 433-6.
13. Berth-Jones J, Bourke J, Eglitis H, Harper C, Kirk P, Pavord S, et al. Value of a second freeze-thaw cycle in cryotherapy of common warts. Br J Dermatol 1994;131:883-6.
14. Young R, Sinclair R. Practical Cryosurgery. Aust Fam Physician 1997;26:1045-7.
15. Lewis TG, Nydorf ED. Intralesional bleomycin for wart: A review. J Drugs Dermatol 2006;5:499-504.
16. Yagoda A, Mukherji B, Young C. Bleomycin: An antitumor antibiotic. Ann Intern Med 1972;77:461-70.
17. Werner Y, Tornberg B. Cutaneous side effects of bleomycin therapy. Acta Derm Venereol 1976;56:155-8.
18. Templeton S F, Solomon SR, Swerlick RA. Intradermal bleomycin injections into normal human skin. Arch Dermatol 1994;130:577-83.
19. Koenig RD, Horwitz LR. Verrucae plantaris. J Foot Surg 1982;21:108-10.
20. Bremner RM. Warts: Treatment with intralesional bleomycin. Cutis 1976;188:264-6.
21. Abess A, Keel DM, Graham BS. Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca vulgaris. Arch Dermatol 2003:139:337-9.
22. Bunney MH, Nolan MW, Buxton PK, Going SM, Prescott RS. The treatment of resistant warts with intralesional bleomycin: A controlled clinical trial. Br J Dermatol 1984;11:197-207.
23. Hayes ME, O'keefe EJ. Reduced dose of bleomycin in the treatment of recalcitrant wart. J Am Acad Dermatol 1986;15:1002-6.
24. Munkavad M, Genner J, Staberg B, Kongsholm H. Locally injected bleomycin in the treatment of warts. Dermatologica 1983;167:86-9.
25. Salk R, Douglas TS. Intralesional bleomycin sulfate injection for the treatment of verruca plantaris. J Am Podiatr Med Assoc 2006;96:220-5.
26. Cordero AA, Guglielmi HA, Woscoff A. The common wart: Intralesional treatment with bleomycin sulfate. Cutis 1980;26:319-20,322,324.
27. Wong KS, Giam YC. Treatment of verruca vulgaris with intralesional bleomycin. Am Acad Med Singapore 1988;17:524-5.
28. Perez AR, Weiss E, Piquero MJ. Hypertonic saline solution vs intralesional bleomycin in the treatment of common warts. J Interferon Res 1982;2:235-43.
29. Adalatkhah H, Khalilollahi H, Amini N, Sadeghi-Bazargani H. Compared therapeutic efficacy between intralesional bleomycin and cryotherapy for common wart: A randomized clinical trial. Dermatol Online J 2007;13:4.
30. Agius E, Mooney JM, Bezzina AC, Yu RC. Dermojet delivery of bleomycin for the treatment of recalcitrant plantar warts. J Dermatol Treat 2006;17:112-6.
31. Munn SE, Higgins E, Marshall M, Clement M. A new method of intralesional bleomycin therapy in the treatment of recalcitrant warts. Br J Dermatol 1996;135:969-71.
32. Shelley WB, Shelley ED. Intralesional bleomycin sulfate therapy for warts: A novel bifurcated needle puncture technique. Arch Dermatol 1991;127:234-6.