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A study of the prognostic validity of inflammatory vertebral lesions on both baseline and follow-up MRI in both a clinical trial and an observational cohort of AS patients receiving anti-TNF therapy. This demonstrated not only an association between vertebral lesions and new syndesmophytes on radiography but also an association between lesions that resolve following treatment and new syndesmophytes. The authors propose the hypothesis that TNF may be important in a well established inflammatory lesion in preventing new bone formation driven by bone growth factors
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