The double danger of ethanol and hypoxia: Their effects on a hepatoma cell line

International Journal of Clinical and Experimental Pathology

Volumn 2, Issue 2, 2009, Pages 182-189

  Wang, Stephanie M ^a   Wu, Rongqian ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Adenosine triphosphate; Cytochrome P450 2E1; Ethanol; Hypoxia; Lactate dehydrogenase

Indexed keywords

EID: 67149102164     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Sommers MS, Dyehouse JM, Howe SR, Fleming M, Fargo JD and Schafer JC. Effectiveness of brief interventions after alcohol-related vehicular injury: A randomized controlled trial. J Trauma 2006;61:523-531.
2. Mitra SK, Varma SR, Godavarthi A and Nandakumar KS. Liv.52 regulates ethanol induced PPARgamma and TNF alpha expression in HepG2 cells. Mol Cell Biochem 2008;315:9-15.
3. Balasubramaniyan V, Shukla R, Murugaiyan G, Bhonde RR and Nalini N. Mouse recombinant leptin protects human hepatoma HepG2 against apoptosis, TNF-alpha response and oxidative stress induced by the hepatotoxin-ethanol. Biochim Biophys Acta 2007;1770: 1136-1144.
4. Itoh H, Takahashi A, Adachi K, Noji H, Yasuda R, Yoshida M and Kinosita K. Mechanically driven ATP synthesis by F1-ATPase. Nature 2004;427:465-468.
5. Baines CP, Kaiser RA, Sheiko T, Craigen WJ and Molkentin JD. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 2007;9: 550-555.
6. Saad LO, Mirandola SR, Maciel EN and Castilho RF. Lactate dehydrogenase activity is inhibited by methylmalonate in vitro. Neurochem Res 2006;31:541-548.
7. Lu Y and Cederbaum AI. CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 2008;44:723-738.
8. Windle M. Alcohol use among adolescents and young adults. Alcohol Res Health 2003; 27:79-85.
9. Schaffer M, Jeglic EL and Stanley B. The Relationship between Suicidal Behavior, Ideation, and Binge Drinking among College Students. Arch Suicide Res 2008;12:124-132.
10. Mantena SK, King AL, Andringa KK, Landar A, rley-Usmar V and Bailey SM. Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease. World J Gastroenterol 2007;13: 4967-4973.
11. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Goto M, Yamashina S, Schemmer P, Kitamura T, Oide H, Takei Y, Hirose M, Shimizu H, Miyazaki A, Brenner DA, Sato N and Thurman RG. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J Gastroenterol Hepatol 2000;15(Suppl):D20-D25.
12. Thurman RG. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998;275:G605-G611.
13. Hoek JB and Pastorino JG. Cellular signaling mechanisms in alcohol-induced liver damage. Semin Liver Dis 2004;24:257-272.
14. Bailey SM and Cunningham CC. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes. Hepatology 1998;28:1318-1326.
15. Bode C and Bode JC. Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol? Alcohol Clin Exp Res 2005;29:166S-171S.
16. Zima T and Kalousova M. Oxidative stress and signal transduction pathways in alcoholic liver disease. Alcohol Clin Exp Res 2005;29: 110S-115S.
17. Hoek JB, Cahill A and Pastorino JG. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002;122: 2049-2063.
18. Cunningham CC and Van Horn CG. Energy availability and alcohol-related liver pathology. Alcohol Res Health 2003;27:291-299.
19. Zhuge J and Cederbaum AI. Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1. Free Radic Biol Med 2006;41:1100-1112.
20. Zakhari S. Overview: how is alcohol metabolized by the body? Alcohol Res Health 2006;29:245-254.
21. Zhuge J and Cederbaum AI. Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. Arch Biochem Biophys 2007;466:177-185.
22. Koop DR. Alcohol metabolism's damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1. Alcohol Res Health 2006;29:274-280.