Identification of low HBV-DNA levels by nucleic acid amplification test (NAT) in blood donors

Journal of Infection

Volumn 59, Issue 2, 2009, Pages 128-133

  Dettori, Stefano ^a   Candido, Angela ^a   Kondili, Loreta A ^a   Chionne, Paola ^a   Taffon, Stefania ^a   Genovese, Domenico ^a   Iudicone, Paola ^b   Miceli, Michelina ^b   Rapicetta, Maria ^a  

^a Viral Hepatitis Unit   (Italy)

^b SAN CAMILLO FORLANINI HOSPITAL   (Italy)

Author keywords

Blood donors; HBsAg; HBV; HBV DNA; NAT

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; VIRUS DNA; VIRUS RNA;

ARTICLE; BLOOD DONOR; BLOOD TRANSFUSION; DNA SEQUENCE; ENDEMIC DISEASE; ENZYME IMMUNOASSAY; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; ITALY; MAJOR CLINICAL STUDY; NUCLEIC ACID AMPLIFICATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEROLOGY; ULTRACENTRIFUGATION;

ADULT; BLOOD; BLOOD DONORS; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPACIVIRUS; HEPATITIS B VIRUS; HIV-1; HUMANS; ITALY; MALE; MIDDLE AGED; NUCLEIC ACID AMPLIFICATION TECHNIQUES; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 67149097372     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2009.06.007     Document Type: Article

References (19)

1. Raimondo G., Navarra G., Mondello S., Costantino L., Colloredo G., Cucinotta E., et al. Occult hepatitis B virus in liver tissue of individuals without hepatic disease. J Hepatol 48 (2008) 743-746
2. Allain J.P. Occult hepatitis B virus infection and transfusion. J Hepatol 44 (2006) 617-618
3. Liu C.J., Lo S.C., Kao J.H., Tseng P.T., Lai M.Y., Ni Y.H., et al. Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan. J Hepatol 44 (2006) 39-46
4. Minuk G.Y., Sun D.F., Greenberg R., Zhang M., Hawkins K., Uhanova J., et al. Occult hepatitis B virus infection in a North American adult hemodialysis patient population. Hepatology 40 (2004) 1072-1077
5. Awerkiew S., Däumer M., Reiser M., Wend U.C., Pfister H., Kaiser R., et al. Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient. J Clin Virol 38 (2007) 83-86
6. Prati D., Gerosa A., and Porretti L. Occult HBV infection and blood transfusion. J Hepatol 44 (2006) 818
7. O'Brien S.F., Fearon M.A., Yi Q.L., Fan W., Scalia V., Muntz I.R., et al. Hepatitis B virus DNA-positive, hepatitis B surface antigen-negative blood donations intercepted by anti-hepatitis B core antigen testing: the Canadian Blood Services experience. Transfusion 47 (2007) 1809-1815
8. Chaudhuri V., Tayal R., Nayak B., Acharya S.K., and Panda S.K. Occult hepatitis B virus infection in chronic liver disease: full-length genome and analysis of mutant surface promoter. Gastroenterology 127 (2004) 1356-1371
9. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Res 41 (1999) 95-98
10. Zanetti A.R., Romanò L., Zappá A., and Velati C. Changing patterns of hepatitis B infection in Italy and NAT testing for improving the safety of blood supply. J Clin Virol 36 (2006) S51-S55
11. Mele A., Tosti M.E., Mariano A., Pizzuti R., Ferro A., Borrini B., et al. Acute hepatitis B 14 years after the implementation of universal vaccination in Italy: areas of improvement and emerging challenges. Clin Infect Dis 46 (2008) 868-875
12. Tosti M.E., Solinas S., Prati D., Salvaneschi L., Manca M., Francesconi M., et al. An estimate of the current risk of transmitting blood-borne infections through blood transfusion in Italy. Br J Haematol 117 (2002) 215-219
13. Coste J., Reesink H.W., Engelfriet C.P., Laperche S., Brown S., Busch M.P., et al. Implementation of donor screening for infectious agents transmitted by blood by nucleic acid technology: update to 2003. Vox Sang 88 (2005) 289-303
14. Manzini P., Girotto M., Borsotti R., Giachino O., Guaschino R., Lanteri M., et al. Italian blood donors with anti-HBc and occult hepatitis B virus infection. Haematologica 92 (2007) 1664-1670
15. Brojer E., Grabarczyk P., Liszewski G., Mikulska M., Allain J.P., and Letowska M. Characterization of HBV DNA+/HBsAg- blood donors in Poland identified by triplex NAT. Hepatology 44 (2006) 1666-1674
16. Reesink H.W., Engelfriet C.P., Henn G., Mayr W.R., Delage G., Bernier F., et al. Occult hepatitis B infection in blood donors. Vox Sang 94 (2008) 153-166
17. Gerlich W.H. Breakthrough of hepatitis B virus escape mutants after vaccination and virus reactivation. J Clin Virol 36 (2006) S18-S22
18. Satake M., Taira R., Yugi H., Hino S., Kanemitsu K., Ikeda H., et al. Infectivity of blood components with low hepatitis B virus DNA levels identified in a look back program. Transfusion 47 (2007) 1197-1205
19. Busch M.P. Prevention of transmission of hepatitis B, hepatitis C and human immunodeficiency virus infections through blood transfusion by anti-HBc testing. Vox Sang 74 (1998) 147-154