Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab

Science

Volumn 324, Issue 5933, 2009, Pages 1444-1447

  Aoki, Scott T ^a   Settembre, Ethan C ^a   Trask, Shane D ^a   Greenberg, Harry B ^b,c   Harrison, Stephen C ^a,e   Dormitzer, Philip R ^a,d,e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^d Novartis Vaccines and Diagnostics Inc   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROTEIN VP4; PROTEIN VP7; VIRUS ANTIGEN;

ANTIBODY; CALCIUM; CATION; CRYSTAL STRUCTURE; INFECTIVITY; MUTATION; NEUTRALIZATION; PHYSIOLOGY; PROTEIN; VIRUS;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE MUTATION; GENE REARRANGEMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE; ROTAVIRUS; VIRUS INFECTIVITY; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; BINDING SITES; BINDING SITES, ANTIBODY; CALCIUM; CAPSID PROTEINS; CRYSTALLOGRAPHY, X-RAY; EPITOPES; IMMUNOGLOBULIN FAB FRAGMENTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NEUTRALIZATION TESTS; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; ROTAVIRUS; SEROTYPING;

ROTAVIRUS;

EID: 67149095009     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1170481     Document Type: Article

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30. We thank M. Babyonyshev for help with protein preparations, the staff of the Northeastern Collaborative Access Team (Advanced Photon Source, Argonne National Laboratory) for assistance with x-ray data collection, R. Stanfield for the library of Fab structures, and J. Patton for help with sequence variability analysis. Supported by NIH grant CA-13202 (S.C.H.), by a VA Merit Award and NIH grants AI-21362 and DK-56339 (H.B.G.), and by an Ellison Medical Foundation New Investigators in Infectious Diseases Award (P.R.D.). S.C.H. is an Investigator of the Howard Hughes Medical Institute. Atomic coordinates and structure factor amplitudes for the VP7-4F8 Fab complex have been deposited in the Protein Data Bank (www.rcsb.org) with accession code 3FMG.