메뉴 건너뛰기




Volumn 21, Issue 4, 2009, Pages 369-373

Denosumab update

Author keywords

Fracture; Osteoporosis; RANKL; Rheumatoid arthritis; Treatment

Indexed keywords

ALENDRONIC ACID; CALCIUM; DENOSUMAB; METHOTREXATE; PLACEBO; VITAMIN D;

EID: 67149091085     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32832ca41c     Document Type: Review
Times cited : (36)

References (26)
  • 2
    • 11844251380 scopus 로고    scopus 로고
    • US Department of Health and Human Services. Rockville, MD: US Department of Health and Human Services, Office of the Surgeon General
    • US Department of Health and Human Services. Bone Health and osteoporosis: a report of the surgeon general. Rockville, MD: US Department of Health and Human Services, Office of the Surgeon General; 2004.
    • (2004) Bone Health and Osteoporosis: A Report of the Surgeon General
  • 3
    • 34247194211 scopus 로고    scopus 로고
    • Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025
    • Burge R, Dawson-Hughes B, Solomon DH, et al. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007; 22:465-475.
    • (2007) J Bone Miner Res , vol.22 , pp. 465-475
    • Burge, R.1    Dawson-Hughes, B.2    Solomon, D.H.3
  • 4
    • 28544448518 scopus 로고    scopus 로고
    • Rheumatic diseases: The effects of inflammation on bone
    • Walsh NC, Crotti TN, Goldring SR, et al. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev 2005; 208:228-251.
    • (2005) Immunol Rev , vol.208 , pp. 228-251
    • Walsh, N.C.1    Crotti, T.N.2    Goldring, S.R.3
  • 5
    • 34548496019 scopus 로고    scopus 로고
    • Economic consequences of established rheumatoid arthritis and its treatment
    • DOI 10.1016/j.berh.2007.05.005, PII S1521694207000617, Established Rheumatoid Arthritis
    • Kavanaugh A. Economic consequences of established rheumatoid arthritis and its treatment. Best Pract Res Clin Rheumatol 2007; 21:929-942. (Pubitemid 47377807)
    • (2007) Best Practice and Research in Clinical Rheumatology , vol.21 , Issue.5 , pp. 929-942
    • Kavanaugh, A.1
  • 7
    • 9344246863 scopus 로고    scopus 로고
    • Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin
    • DOI 10.1161/01.RES.0000149165.99974.12
    • Collin-Osdoby P. Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res 2004; 95:1046-1057. (Pubitemid 39557891)
    • (2004) Circulation Research , vol.95 , Issue.11 , pp. 1046-1057
    • Collin-Osdoby, P.1
  • 8
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997; 89:309-319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 9
    • 3242781731 scopus 로고    scopus 로고
    • Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases
    • DOI 10.1001/jama.292.4.490
    • Hofbauer LC, Schoppet M. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. J Am Med Assoc 2004; 292:490-495. (Pubitemid 38988958)
    • (2004) Journal of the American Medical Association , vol.292 , Issue.4 , pp. 490-495
    • Hofbauer, L.C.1    Schoppet, M.2
  • 10
    • 27744529640 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength
    • DOI 10.1016/j.coph.2005.06.005, PII S1471489205001499
    • Kostenuik PJ. Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 2005; 5:618-625. (Pubitemid 41614462)
    • (2005) Current Opinion in Pharmacology , vol.5 , Issue.6 SPEC. ISS , pp. 618-625
    • Kostenuik, P.J.1
  • 12
    • 38749105490 scopus 로고    scopus 로고
    • Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low bone mineral density
    • Lewiecki EM, Miller PD, McClung MR, et al. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low bone mineral density. J Bone Miner Res 2007; 22:1832-1841.
    • (2007) J Bone Miner Res , vol.22 , pp. 1832-1841
    • Lewiecki, E.M.1    Miller, P.D.2    McClung, M.R.3
  • 13
    • 52449112052 scopus 로고    scopus 로고
    • Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial
    • The effects of denosumab continuation, discontinuation, and restarting suggest that BMD and BTM effects are favorable with continuation, reversible with discontinuation, and recoverable with restarting
    • Miller PD, Bolognese MA, Lewiecki EM, et al. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone 2008; 43:222-229. The effects of denosumab continuation, discontinuation, and restarting suggest that BMD and BTM effects are favorable with continuation, reversible with discontinuation, and recoverable with restarting.
    • (2008) Bone , vol.43 , pp. 222-229
    • Miller, P.D.1    Bolognese, M.A.2    Lewiecki, E.M.3
  • 14
    • 33646374730 scopus 로고    scopus 로고
    • Phase 2 study of denosumab (AMG 162) in postmenopausal women: Subanalyses and supplemental safety
    • Cohen SB, Lewiecki EM, Liu Y, et al. Phase 2 study of denosumab (AMG 162) in postmenopausal women: subanalyses and supplemental safety. J Bone Miner Res 2005; 20 (Suppl 1):S295.
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Cohen, S.B.1    Lewiecki, E.M.2    Liu, Y.3
  • 16
    • 59349089191 scopus 로고    scopus 로고
    • A phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: Results from the FREEDOM trial
    • FREEDOM is the phase III registration trial for the treatment of PMO, showing reduction in the risk of vertebral, hip, and nonvertebral fracture risk
    • Cummings SR, McClung MR, Christiansen C, et al. A phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: results from the FREEDOM trial. J Bone Miner Res 2008; 23 (Suppl 1):S80. FREEDOM is the phase III registration trial for the treatment of PMO, showing reduction in the risk of vertebral, hip, and nonvertebral fracture risk.
    • (2008) J Bone Miner Res , vol.23 , Issue.SUPPL. 1
    • Cummings, S.R.1    McClung, M.R.2    Christiansen, C.3
  • 17
    • 67149109869 scopus 로고    scopus 로고
    • Accessed on 16 September 2008
    • Amgen Inc. Form 8-K. http://investors.amgen.com/phoenix.zhtml?c= 61656&p=irol-sec. Accessed on 16 September 2008.
    • Form 8-K
  • 18
    • 58149099647 scopus 로고    scopus 로고
    • Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: A randomized, blinded, phase 3 trial
    • DECIDE showed that denosumab increases BMD and suppresses BTMs more than alendronate, with a similar safety profile
    • Brown JP, Prince RL, Deal C, et al. Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res 2009; 24:153-161. DECIDE showed that denosumab increases BMD and suppresses BTMs more than alendronate, with a similar safety profile.
    • (2009) J Bone Miner Res , vol.24 , pp. 153-161
    • Brown, J.P.1    Prince, R.L.2    Deal, C.3
  • 19
    • 59349097396 scopus 로고    scopus 로고
    • Effects of denosumab vs. alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate
    • STAND demonstrated that patients switched from alendronate to denosumab have a greater BMD increase than those continuing to take alendronate
    • Kendler DL, Benhamou CL, Brown JP, et al. Effects of denosumab vs. alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate. J Bone Miner Res 2008; 23 (Suppl 1):S473. STAND demonstrated that patients switched from alendronate to denosumab have a greater BMD increase than those continuing to take alendronate.
    • (2008) J Bone Miner Res , vol.23 , Issue.SUPPL. 1
    • Kendler, D.L.1    Benhamou, C.L.2    Brown, J.P.3
  • 20
    • 43949139580 scopus 로고    scopus 로고
    • Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial
    • Denosumab was shown to have favorable effect on bone erosion scores in patients with RA who are also taking methotrexate
    • Cohen SB, Dore RK, Lane NE, et al. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum 2008; 58:1299-1309. Denosumab was shown to have favorable effect on bone erosion scores in patients with RA who are also taking methotrexate.
    • (2008) Arthritis Rheum , vol.58 , pp. 1299-1309
    • Cohen, S.B.1    Dore, R.K.2    Lane, N.E.3
  • 21
    • 8644234910 scopus 로고    scopus 로고
    • Antibody pharmacokinetics and pharmacodynamics
    • Lobo ED, Hansen RJ, Balthasar JP. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci 2004; 93:2645-2668.
    • (2004) J Pharm Sci , vol.93 , pp. 2645-2668
    • Lobo, E.D.1    Hansen, R.J.2    Balthasar, J.P.3
  • 23
    • 33745627615 scopus 로고    scopus 로고
    • The pharmacokinetics of denosumab (AMG 162) following various multiple subcutaneous dosing regimens in postmenopausal women with low bone mass
    • Peterson MC, Stouch BJ, Martin SW, et al. The pharmacokinetics of denosumab (AMG 162) following various multiple subcutaneous dosing regimens in postmenopausal women with low bone mass. J Bone Miner Res 2005; 20:S293.
    • (2005) J Bone Miner Res , vol.20
    • Peterson, M.C.1    Stouch, B.J.2    Martin, S.W.3
  • 24
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-324.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3
  • 26
    • 0033984107 scopus 로고    scopus 로고
    • How to read radiographs according to the Sharp/van der Heijde method
    • van der Heijde D. How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 2000; 27:261-263. (Pubitemid 30058662)
    • (2000) Journal of Rheumatology , vol.27 , Issue.1 , pp. 261-263
    • Van Der Heijde, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.