Development and characterization of new indomethacin self-nanoemulsifying formulations

Scientia Pharmaceutica

Volumn 77, Issue 2, 2009, Pages 443-451

  Taha, Ehab I ^a,b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Al Azhar University   (Egypt)

Author keywords

Dissolution; DSC; Indomethacin; Nanoemulsion; SNEDDF

Indexed keywords

CASTOR OIL; CREMOPHOR; GELATIN; INDOMETACIN; OCTANOIN;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; NANOEMULSION; TURBIDITY;

EID: 67149087355     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.0811-24     Document Type: Article

References (15)

1. Inoue K, Fujisawa H, Motonaga A, Inoue Y, Kyoi T, Ueda F,Kimura K. Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. Biol Pharm Bull. 1994; 17: 1577-1583. PMid:7735198
2. Al Za'abi MA, Dehghanzadeh GH, Norris RL, Charles BG. A rapid and sensitive microscale HPLC method for the determination of indomethacin in plasma of premature neonates with patent ductus arteriousus. J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 830: 364-367. doi:10.1016/j.jchromb.2005.11.025
3. Yokota A, Taniguchi M, Tanaka A, Takeuchi K. Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib. Inflammopharmacology. 2005; 13: 209-216. doi:10.1163/ 156856005774423755 (Pubitemid 41607381)
4. Dengiz GO, Odabasoglu F, Halici Z, Suleyman H, Cadirci E, Bayir Y. Gastroprotective and antioxidant effects of amiodarone on indomethacin induced gastric ulcers in rats. Arch Pharm Res. 2007; 30: 1426-1434. doi:10.1007/BF02977367 (Pubitemid 47469686)
5. Risty GM, Najarian MM, Shapiro SB. Multiple indomethacin induced jejunal ulcerations with perforation: a case report with histology. Am Surg. 2007; 73: 344-6. PMid:17439025
6. Charman SA, Charman WN, Rogge MC, Wilson TD, Dutko PJ, Pouton CW. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res. 1992; 9: 87-93. doi:10.1023/A:1018987928936
7. Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm. 2000; 50: 179-188. doi:10.1016/S0939-6411(00)00089-98 (Pubitemid 30326696)
8. Taha EI, Al-Saidan S, Samy AM, Khan MA. Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Int J Pharm. 2004; 285: 109-119. doi:10.1016/j. ijpharm.2004.03.034 (Pubitemid 39361541)
9. Craig DQ, Barker SA, Banning D, Booth SW. An investigation into the mechanism of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm. 1995. 114: 103-110. doi:10.1016/0378- 5173(94)00222-Q (Pubitemid 24377034)
10. Nazzal S, Smalyukh II, Lavrentovich OD, Mansoor AK. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formulation. Int J Pharm. 2002; 235: 247-265. doi:10.1016/S0378-5173(02)00003-10 (Pubitemid 34185455)
11. Gong K, Darr JA, Rehman IU. Supercritical fluid assisted impregnation of indomethacin into chitosan thermosets for controlled release applications. Int J Pharm. 2006; 315: 93-98. doi:10.1016/j.ijpharm.2006.02.030 (Pubitemid 43674107)
12. Pouton CW. Lipid formulations for oral administration of drug non-emulsifying, self-emulsifying and self-microemulsifying drug delivery system. Eur J Pharm Sci. 2000; 11 (Suppl 2), S93-S98. doi:10.1016/S0928-0987(00) 00167-176 (Pubitemid 30734421)
13. Reiss H. Entropy-induced dispersion of bulk liquids. J Colloid Interface Sci. 1975; 53: 61-70. doi:10.1016/0021-9797(75)90035-90041
14. Constantinides PP, Scalart JP. Formulation and physical characterisation of water in oil microemulsions containing long versus medium chain length glycerides. Int J Pharm. 1997; 158: 57-68. doi:10.1016/S0378-5173(97)00248-252 (Pubitemid 27504474)
15. Pouton CW. Self-emulsifying drug delivery systems. Assessment of the efficiency of emulsification. Int J Pharm. 1985; 27: 335-348. doi:10.1016/0378-5173(85) (Pubitemid 16218683)