Release mechanisms of a sparingly water-soluble drug from controlled porosity-osmotic pump pellets using sulfobutylether-β-cyclodextrin as both a solubilizing and osmotic agent

Journal of Pharmaceutical Sciences

Volumn 98, Issue 6, 2009, Pages 1992-2000

  Sotthivirat, Sutthilug ^a,d   Haslam, John L ^a   Lee, Ping I ^b   Rao, Venkatramana M ^c   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c BRISTOL MYERS SQUIBB   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Controlled release; Investigation; Mechanism; Pellet; Prednisolone; Sulfobutylether beta cyclodextrin

Indexed keywords

BETA CYCLODEXTRIN SULFOBUTYL ETHER; PREDNISOLONE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG SOLUBILITY; HYDRAULIC PERMEABILITY; INFUSION PUMP; MATERIAL COATING; MEMBRANE PERMEABILITY; OSMOLALITY; OSMOTIC PUMP; POROSITY; VISCOSITY; WATER PERMEABILITY;

EID: 67049169035     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21567     Document Type: Article

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