Upregulation of hypoxia-inducible factor-1αmRNA and its clinical significance in non-small cell lung cancer

Journal of Thoracic Oncology

Volumn 4, Issue 3, 2009, Pages 284-290

  Yohena, Tomofumi ^a,b   Yoshino, Ichiro ^c   Takenaka, Tomoyoshi ^a   Kameyama, Toshifumi ^a   Ohba, Taro ^a   Kuniyoshi, Yukio ^b   Maehara, Yoshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Hypoxia inducible factor; Non small cell lung carcinoma; Type II hexokinase; Vascular endothelial growth factor

Indexed keywords

HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN; TUMOR MARKER; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; CANCER STAGING; COHORT ANALYSIS; COMPARATIVE STUDY; DISEASE COURSE; GENETICS; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METABOLISM; MORTALITY; PATHOLOGY; PROBABILITY; SENSITIVITY AND SPECIFICITY; SURVIVAL; TISSUE CULTURE TECHNIQUE;

CARCINOMA, NON-SMALL-CELL LUNG; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; NEOPLASM STAGING; PROBABILITY; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TISSUE CULTURE TECHNIQUES; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67049165796     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31819852d5     Document Type: Article

References (58)

1. Dang CV, Semenza GL. Oncogenic alterations of metabolism. Trends Biochem Sci 1999;24:68-72.
2. Maxwell PH, Wiesener MS, Chang GW, et al. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999;399:271-275.
3. Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxiainducible factor 1α in common human cancers and their metastases. Cancer Res 1999;59:5830-5835.
4. Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 2002;8:S62-S67. Review.
5. Zhu H, Jackson T, Bunn HF. Detecting and responding to hypoxia. Nephrol Dial Transplant 2002;17(Suppl 1):3-7. Review. (Pubitemid 34157112)
6. 2 tension. Proc Natl Acad Sci USA 1995;92:5510-5514.
7. Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial and oxygen-regulated expression of hypoxia- inducible factor-1 in the lung. Am J Physiol 1998;275:L818-L826. (Pubitemid 28491865)
8. Huang LE, Arany Z, Livingston DM, Bunn HF. Activation of hypoxiainducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 1996;271:32253-32259. (Pubitemid 26422262)
9. 2 tension. Am J Physiol 1996;271:C1172-C1180. (Pubitemid 126757715)
10. Sutter CH, Laughner E, Semenza GL. Hypoxia inducible factor 1alpha protein expression is controlled by oxygen- regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000;97:4748-4753. (Pubitemid 30238629)
11. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;10:721-732. Review.
12. Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-induced factor 1alpha. Genes Dev 2000;14:34-44. (Pubitemid 30051577)
13. Ratcliffe PJ, O'Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducible factor-1 and regulation of mammalian gene expression. J Exp Biol 1998;201:1153-1162. (Pubitemid 28278320)
14. Matthews NE, Adams MA, Maxwell LR, Gofton TE, Graham CH. Nitric oxide-mediated regulation of chemosensitivity in cancer cells. J Natl Cancer Inst 2001;93:1879-1885. (Pubitemid 34048655)
15. Yasuda H, Yamaya M, Nakayama K, et al. Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer. J Clin Oncol 2006;24:688-694. (Pubitemid 46630435)
16. Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-890. (Pubitemid 33010557)
17. Volm M, Koomagi R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 2000;20:1527-1533. (Pubitemid 30628160)
18. Jones A, Fujiyama C, Blanche C, et al. Relation of vascular endothelial growth factor production to expression and regulation of hypoxiainducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines. Clin Cancer Res 2001;7:1263-1272. (Pubitemid 32708679)
19. Turner KJ, Moore JW, Jones A, et al. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res 2002;62:2957-2961. (Pubitemid 34525785)
20. Zhong H, Agani F, Baccala AA, et al. Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer. Cancer Res 1998;58:5280-5284. (Pubitemid 28551099)
21. Matsuyama T, Nakanishi K, Hayashi T, et al. Expression of hypoxiainducible factor-1alpha in esophageal squamous cell carcinoma. Cancer Sci 2005;96:176-182. (Pubitemid 40575919)
22. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E, Sobin LH. Histological Typing of Lung and Pleural Tumours: World Health Organization International Histological Classification of Tumours. Berlin, Germany: Springer, 1999.
23. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997;111:1710 -1717. (Pubitemid 27260107)
24. Bos R, Zhong H, Hanrahan CF, et al. Levels of hypoxia-inducible factor-1α during breast carcinogenesis. J Natl Cancer Inst 2001;93:309-314. (Pubitemid 32219818)
25. Lee CH, Lee MK, Kang CD, et al. Differential expression of hypoxia inducible factor-1 alpha and tumor cell proliferation between squamous cell carcinomas and adenocarcinomas among operable non-small cell lung carcinomas. J Korean Med Sci 2003;18:196-203.
26. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res 1996;88:986-994. (Pubitemid 26388091)
27. Gibson UE, Heid CA, Williams PM. A novel method for real time quantitative RT-PCR. Genome Res 1996;6:995-1000.
28. Bieche I, Laurendeau I, Tozlu S, et al. Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription- PCR assay. Cancer Res 1999;59:2759-2765. (Pubitemid 29283103)
29. Cox D. Regression model and life-tables. J R Stat Soc 1972;34:187-220.
30. Kaplan EL, Meyer P. Non parametric estimation from incomplete observation. J Am Stat Assoc 1958;53:457-481.
31. Saha S, Bardelli A, Buckhaults P, et al. A phosphatase associated with metastasis of colorectal cancer. Science 2001;294:1343-1346. (Pubitemid 33063101)
32. Bardelli A, Saha S, Sager JA, et al. PRL-3 expression in metastatic cancers. Clin Cancer Res 2003;9:5607-5615. (Pubitemid 37499481)
33. Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1 alpha is a marker for an unfavorable prognosis in early stage invasive cervical cancer. Cancer Res 2000;60:4693-4696. (Pubitemid 30701471)
34. Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1 alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-2916. (Pubitemid 32691934)
35. Birner P, Gatterbauer B, Oberhuber G, et al. Expression of Hypoxiainducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and neoangiogenesis. Cancer 2001;92:165-171. (Pubitemid 32623053)
36. Nakayama K, Kanzaki A, Hata K, et al. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma. Cancer Lett 2002;176:215-223. (Pubitemid 34136021)
37. Beasley NJ, Leek R, Alam M, et al. Hypoxia-inducible factors HIF- 1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res 2002;62:2493-2497. (Pubitemid 34462724)
38. Lau SK, Boutros PC, Pintilie M, et al. Three-gene prognostic classifier for early-stage non small-cell lung cancer. J Clin Oncol 2007;25:5562-5569.
39. Ryan HE, Poloni M, McNulty W, et al. Hypoxia-inducible factor-1 is a positive factor in solid tumor growth. Cancer Res 2000;60:4010-4015. (Pubitemid 30636574)
40. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev 1998;12: 149-162. (Pubitemid 28060446)
41. Ryan HE, Lo J, Johnson RS. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J 1998;17:3005-3015. (Pubitemid 28254373)
42. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α in hypoixiamediated apoptosis, cell proliferation, and tumour angiogenesis. Nature 1998;394:485-490. (Pubitemid 28373960)
43. Yoshino I, Baba H, Fukuyama S, et al. A time trend of profile and surgical results in 1123 patients with non-small cell lung cancer. Surgery 2002;131:S242-S248. (Pubitemid 34118648)
44. Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
45. Bruick RK, McKnight SL. A conserved family of prolyl-4- hydroxylases that modify HIF. Science 2001;294:1337-1340.
46. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 1998;95:7987-7992. (Pubitemid 28326053)
47. Kallio PJ, Wilson WJ, O' Brien S, Makino Y, Poellinger L. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J Biol Chem 1999;274:6519-6525. (Pubitemid 29111068)
48. Salceda S, Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: its stabilization by hypoxia depends upon redox-induced changes. J Biol Chem 1997;272:22642-22647. (Pubitemid 27386079)
49. Sutter CH, Laughner E, Semenza GL. HIF-1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000;97:4748-4753. (Pubitemid 30238629)
50. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 1998;17:5085-5094. (Pubitemid 28408474)
51. Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulinlike growth factor 2. Cancer Res 1999;59:3915-3918. (Pubitemid 29393552)
52. Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3 kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-1545. (Pubitemid 30183422)
53. Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Bürgel T. Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin- 1beta involves the phosphatidylinositol 3.-kinase pathway. FEBS Lett 2002;512:157-162. (Pubitemid 34164471)
54. Hellwig-Burgel T, Rutkowski K, Metzen E, et al. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 1999;94:1561-1567. (Pubitemid 29411306)
55. Sandau KB, Zhou J, Kietzmann T, Brüne B. Regulation of the hypoxiainducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide. J Biol Chem 2001;276:39805-39811. (Pubitemid 37391388)
56. Haddad JJ, Land SC. A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett 2001;505: 269-274.
57. Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L. Hypoxiainducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation. Biochem J 2003;370:1011-1017. (Pubitemid 36399095)
58. Zhou J, Schmid T, Brune B. Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor- kappaB- dependent pathway. Mol Biol Cell 2003;14:2216-2225. (Pubitemid 36724315)