Analysis of Foxp2 expression in the cerebellum reveals a possible sex difference

NeuroReport

Volumn 20, Issue 6, 2009, Pages 611-616

  Hamson, Dwayne K ^a   Csupity, Attila S ^a   Gaspar, John M ^a   Watson, Neil V ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Androgen insensitivity; Androgens; Purkinje cell layer; Sexual dimorphism; Testicular feminization mutation; Testosterone

Indexed keywords

ANDROGEN; TRANSCRIPTION FACTOR FOXP2; FORKHEAD TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; PUTAMEN; RAT; SEX DIFFERENCE; TESTICULAR FEMINIZATION; ANALYSIS OF VARIANCE; ANDROGEN INSENSITIVITY SYNDROME; ANIMAL; IMMUNOHISTOCHEMISTRY; METABOLISM; OVARIECTOMY; RAT STRAIN; SEXUAL DEVELOPMENT; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANDROGEN-INSENSITIVITY SYNDROME; ANDROGENS; ANIMALS; CAUDATE NUCLEUS; CEREBELLUM; ESTROUS CYCLE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOHISTOCHEMISTRY; MALE; OVARIECTOMY; PURKINJE CELLS; PUTAMEN; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS;

EID: 67049165175     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32832a0a44     Document Type: Article

References (25)

1. Kaestner KH, Knöchel W, Martinez DE. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Devel 2000; 14:142-146.
2. Vargha-Khadem F, Gadian DG, Copp A, Mishkin M. FOXP2 and the neuroanatomy of speech and language. Nat Rev Neurosci 2005; 6:131-138.
3. Shu W, Cho JY, Jiang Y, Zhang M, Weisz D, Elder GA, et al. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proc Natl Acad Sci USA 2006; 102:9643-9648.
4. Watkins KE, Vargha-Khadem F, Ashburner J, Passingham RE, Connelly A, Friston KJ, et al. MRI analysis of an inherited speech and language disorder: structural brain abnormalities. Brain 2002; 125:465-478.
5. Mcintosh TK, Barfield RJ, Geyer LA. Ultrasonic vocalizations facilitate sexual behavior of female rats. Nature 1978; 272:163-164.
6. Floody OR, Bauer GB. Selectivity in the responses of hamsters to conspecific vocalizations. Horm Behav 1987; 21:522-527.
7. McGinnis MY, Vakulenko M. Characterization of 50-kHz ultrasonic vocalizations in male and female rats. Physiol Behav 2003; 80:81-88.
8. Vagell ME, McGinnis MY. The role of gonadal steroid receptor activation in the restoration ofsociosexual behavior in adult male rats. HormBehav 1998; 33:163-179.
9. Yarbrough WG, Quarmby VE, Simental JA, Joseph DR, Sar M, Lubahn DB, et al. A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem 1990;265:8893-8900.
10. Beach FA, Buehler MG. Male rats with inherited insensitivity to androgen show reduced sexual behavior. Endocrinology1977; 100:197-200.
11. Breedlove SM, Arnold AP. Sexually dimorphic motor nucleus in the rat lumbar spinal cord: response to adult hormone manipulation, absence in androgen-insensitive rats. Brain Res 1981; 225:297-307.
12. Ferland RJ, Cherry TJ, Preware PO, Morrisey EE, Walsh CA. Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. J Comp Neurol 2003; 460:266-279.
13. Simerly RB, Chang C, Muramatsu M, Swanson LW. Distribution ofandrogen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 1990; 294:76-95.
14. Miller JE, Spiteri E, Condro MC, Dosumu-Johnson RT, Geschwind DH, White SA. Birdsong decreases protein levels of FoxP2, a molecule required for human speech. J Neurophysiol 2008; 100:2015-2025.
15. Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, et al. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet 2007;81:1144-1157.
16. Fujita E, Tanabe Y, Shiota A, Ueda M, Suwa K, Momoi MY, et al. Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells. Proc Natl Acad Sci U S A 2008; 105:3117-3122.
17. Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, et al. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 2006; 16:995-1004.
18. Arnold AP, Gorski RA. Gonadal steroid induction of structural sex differences in the central nervous system. Annu Rev Neurosci 1984;7:413-442.
19. Watson NV, Freeman LM, Breedlove SM. Neuronal size in the spinal nucleus of the bulbocavernosus: direct modulation by androgen in rats with mosaic androgen insensitivity. J Neurosci 2001; 21:1062-1066.
20. Roselli CE, Resko JA. The distribution and regulation of aromatase activity in the central nervous system. Steroids 1987; 50:495-508.
21. Li X, Schwartz PE, Rissman EF. Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain. Neuroendocrinology 1997; 66:63-67.
22. Ikeda Y, Nagai A. Differential expression of the estrogen receptors alpha and beta during postnatal development of the rat cerebellum. Brain Res 2006; 1083:39-49.
23. Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, et al. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proc Natl Acad Sci USA 2000; 97:14737-14741.
24. Floody OR. Dissociation of hypothalamic effects on ultrasound production and copulation. Physiol Behav 1989; 46:299-307.
25. Sipos ML, Nyby JG. Intracranial androgenic activation of male-typical behaviors in house mice: concurrent stimulation of the medial preoptic area and medial nucleus of the amygdala. J Neuroendocrinol 1998;10:577-586.