Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents

Magnetic Resonance in Medicine

Volumn 61, Issue 6, 2009, Pages 1489-1493

  Van Heeswijk, Ruud B ^a   Uffmann, Kai ^a   Comment, Arnaud ^a   Kurdzesau, Fiodar ^a,b   Perazzolo, Chiara ^a   Cudalbu, Cristina ^a   Jannin, Sami ^a   Konter, Jacobus A ^b   Hautle, Patrick ^b   Van Den Brandt, Ben ^b   Navon, Gil ^c   Van Der Klink, Jacques J ^a   Gruetter, Rolf ^a,d,e  

^a EPFL   (Switzerland)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c TEL AVIV UNIVERSITY   (Israel)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

^e UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

DNP; Hyperpolarization; Lithium 6; Relaxivity

Indexed keywords

MOLECULAR IMAGING; RELAXATION TIME;

6LI ISOTOPES; CONTRAST AGENT; HYPERPOLARIZATION; HYPERPOLARIZED; LITHIUM-6; LONGITUDINAL RELAXATION TIME; POLARIZATION DECAY; RELAXIVITY;

LITHIUM;

CONTRAST MEDIUM; DEUTERIUM OXIDE; GADOLINIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRA(METHYLENEPHOSPHONATE); LITHIUM; LITHIUM 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; DRUG BLOOD LEVEL; DRUG UPTAKE; DYNAMIC NUCLEAR POLARIZATION; HYPERPOLARIZATION; IMAGING SYSTEM; MAGNET; MALE; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHANTOM; RAT; SIGNAL NOISE RATIO; SPECTROMETER;

EID: 67049134873     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21952     Document Type: Article

References (20)

1. Cade JF. Lithium salts in the treatment of psychotic excitement. Med J Aust 1949;2:349-352.
2. Thase ME, Denko T. Pharmacotherapy of mood disorders. Annu Rev Clin Psychol 2008;4:53-91. (Pubitemid 351668611)
3. Brevard C, Granger P. Handbook of high resolution multinuclear NMR. New York: John Wiley & Sons; 1981. p 84-85.
4. Komoroski RA, Pearce JM, Newton JE. Lithium visibility in rat brain and muscle in vivo by 7Li NMR imaging. J Magn Reson 1998;133:98-103. (Pubitemid 128450615)
5. Ramaprasad S, Ripp E, Pi J, Lyon M. Pharmacokinetics of lithium in rat brain regions by spectroscopic imaging. Magn Reson Imaging 2005;23:859-863. (Pubitemid 41579028)
6. Villafranca JJ, Raushel FM. Biophysical applications of NMR to phosphoryl transfer enzymes and metal nuclei of metalloproteins. Annu Rev Biophys Bioeng 1980;9:363-392.
7. Wehrli FW. Temperature-dependent spin-lattice relaxation of 6Li in aqueous lithium chloride. J Magn Reson 1976;23:527-532.
8. Abragam A, Goldman M. Principles of dynamic nuclear polarisation. Rep Prog Phys 1978;41:395-467.
9. Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K. Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A 2003;100:10158-10163.
10. Golman K, Zandt RI, Lerche M, Pehrson R, Ardenkjaer-Larsen JH. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res 2006;66:10855-10860. (Pubitemid 44876982)
11. Comment A, van den Brandt B, Uffmann K, Kurdzesau F, Jannin S, Konter JA, Hautle P, Wenckebach WTH, Gruetter R, van der Klink JJ. Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner. Concepts Magn Reson 2007;31B:255-269.
12. Gallagher FA, Kettunen MI, Day SE, Hu DE, Ardenkjaer-Larsen JH, Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature 2008;453:940-943. (Pubitemid 351832568)
13. van Heeswijk RB, Laus S, Morgenthaler FD, Gruetter R. Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions. Magn Reson Imaging 2007;25:821-825. (Pubitemid 47081355)
14. Kurdzesau F, van den Brandt B, Comment A, Hautle P, Jannin S, van der Klink JJ, Konter JA. Dynamic nuclear polarization of small labelled molecules in frozen water-alcohol solutions. J Phys D-Appl Phys 2008;41.
15. Gruetter R. Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson Med 1993;29:804-811. (Pubitemid 23182863)
16. Sherry AD, Malloy CR, Jeffrey FMH, Cacheris WP, Geraldes CFGC. Dy(Dotp)5- - a new, stable Na-23 shift-reagent. J Magn Reson 1988;76:528-533.
17. RTECS (Registry of Toxic Effects of Chemical Substances). Lithium chloride. The Risk Assessment Information System: National Institute of Occupational Safety and Health, Cincinnati, OH; 1995.
18. Garwood M, Yong K. Symmetrical pulses to induce arbitrary flip angles with compensation for Rf inhomogeneity and resonance offsets. J Magn Reson 1991;94:511-525.
19. Davenport VD. Distribution of parenterally administered lithium in plasma, brain and muscle of rats. Am J Physiol 1950;163:633-641.
20. Ebadi MS, Simmons VJ, Hendrickson MJ, Lacy PS. Pharmacokinetics of lithium and its regional distribution in rat brain. Eur J Pharmacol 1974;27:324-329.