Anemia: An independent predictor of death and hospitalizations among elderly patients with atrial fibrillation

American Heart Journal

Volumn 157, Issue 6, 2009, Pages 1057-1063

  Sharma, Shivak ^a   Gage, Brian F ^a   Deych, Elena ^a   Rich, Michael W ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; AGED; ANEMIA; ARTICLE; COHORT ANALYSIS; COMORBIDITY; FEMALE; HEART ATRIUM FIBRILLATION; HEMATOCRIT; HOSPITALIZATION; HUMAN; MALE; MEDICARE; MORTALITY; PREDICTION AND FORECASTING; PROPORTIONAL HAZARDS MODEL; REGISTER; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL; UNITED STATES;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANEMIA; ATRIAL FIBRILLATION; COHORT STUDIES; COMORBIDITY; FEMALE; HEMATOCRIT; HOSPITALIZATION; HUMANS; MALE; MEDICARE; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; REGISTRIES; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; UNITED STATES;

EID: 67049098530     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2009.03.009     Document Type: Article

References (28)

1. Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: the An Ticoagulation and Risk Factors In Atrial Fibrillation (ATRIA) Study. JAMA 2001;285:2370-5. (Pubitemid 32424106)
2. Hobbs FD, Fitzmaurice DA, Mant J, etal. A randomised controlled trial and cost-effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in people aged 65 and over. The SAFE study. Health Technol Assess 2005;9:1-74.
3. Benjamin EJ, Wolf PA, D'Agostino RB, etal. Impactof atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 1998; 98:946-52. (Pubitemid 28446646)
4. Steensma D, Tefferi A. Anemia in the Elderly: how should we define it, when does it matter, and what can be done? Mayo Clin Proc 2007;82: 958-66. (Pubitemid 47206371)
5. Horwich TB, Fonarow GC, Hamilton MA, et al. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol 2002;39:1780-6. (Pubitemid 34595288)
6. Muzzarelli S, Pfisterer M. Anemia as independent predictor of major events in elderly patients with chronic angina. Am Heart J 2006;152: 991-6. (Pubitemid 44632950)
7. Vaglio J, Safley DM, Rahman M, etal. Relation ofanemiaatdischarge to survival after acute coronary syndromes. Am J Cardiol 2005;96: 496-9. (Pubitemid 41132763)
8. Caro JJ, Salas M, Ward A, et al. Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review. Cancer 2001;91:2214-21. (Pubitemid 32552805)
9. Fangman JJ, Scadden DT. Anemia in HIV-infected adults: epidemiol-ogy, pathogenesis, and clinical management. Curr Hematol Rep 2005;4:95-102.
10. Yan Y, Birman-Deych E, Radford MJ, et al. Comorbidity indices to predict mortality from Medicare data: results from the national registry of atrial fibrillation. Med Care 2005;43:1073-7. (Pubitemid 41587592)
11. Ezekowitz JA, Mc Alister FA, Armstrong PW, et al. The interaction among sex, hemoglobin and outcomes in specialty heart failure clinic. Can J Cardiol 2005;21:165-71. (Pubitemid 40484805)
12. Liu XM, Kang JP, Lu Q, et al. Anemia is an independent predictor of poor long term outcomes after percutaneous coronary intervention. Zhonghua Nei Ke Za Zhi 2008;47:114-6.
13. Go AS, Yang J, Ackerson LM, et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure. The Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study. Circulation 2006;113:2713-23.
14. Mozaffarian D, Nye R, Levy WC. Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE). J Am Coll Cardiol 2003;41:1933-9. (Pubitemid 36677110)
15. Szachniewicz J, Petruk-Kowalczyk J, Majda J, et al. Anaemia is an independent predictor of poor outcome in patients with chronic heart failure. Int J Cardiol 2003;90:303-8. (Pubitemid 37087891)
16. Silverberg DS, Wexler D, Sheps D, et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study. J Am Coll Cardiology 2001;37:1775-80. (Pubitemid 32499958)
17. Palazzuoli A, Silverberg D, Iovine F, et al. Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. Am Heart J 2006;152:1096.e9-1096.e15.
18. Bolger AP, Bartlett FR, Penston HS, et al. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. J Am Coll Cardiol 2006;48:1225-7. (Pubitemid 44345150)
19. Ponikowski P, Anker SD, Szachniewicz J, et al. Effect of darbepoetin alfa on exercise tolerance in anemic patients with symptomatic chronic heart failure. J Am Coll Cardiol 2007;49:753-62.
20. Ghali JK, Anand IS, Abraham WT, et al. Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia. Circulation 2008;117:526-35.
21. Wu WC, Rathore SS, Wang Y, et al. Blood transfusion inelderlypatients with acute myocardial infarction. N Engl J Med 2001; 345: 1230-6. (Pubitemid 34951486)
22. Rao SV, Jollis JG, Harrington RA, et al. Relationship of blood transfusion on clinical outcomes in patients with acute coronary syndromes. JAMA 2004;292:1555-62. (Pubitemid 39314961)
23. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999;340:409-17. (Pubitemid 29084771)
24. Singh AK, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006;355:2085-98. (Pubitemid 44749317)
25. Corwin HL, Gettinger A, Fabian TC, etal. Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med 2007; 357: 965-76. (Pubitemid 47367076)
26. Park J, Gage BF, Vijayan A. Use of EPO in critically ill patients with acute renal failure requiring renal replacement therapy. Am J Kidney Dis 2005;46:791-8. (Pubitemid 41505452)
27. U.S. Food and Drug Administration. Center for Drug Evaluation and Research. information on erythropoiesis-stimulating agents (ESAs). Rockville, MD: Food and Drug Administration, January 26, 2009. Available at: http://www.fda.gov/cder/drug/infopage/ RHE/default.htm. Last accessed Feb 9, 2009.
28. Zhang QL, Koenig W, Raum E, et al. Epidemiology of chronic kidney disease: results from a population of older adults in Germany. Prev Med 2008 [Electronic publication].