Blockade of PGHS-2 inhibits the hypothalamus-pituitary-adrenal axis response to cerebral hypoperfusion in the sheep fetus

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 6, 2009, Pages

  Wood, Charles E ^a,b   Fraites, Melanie Powers ^a   Keller Wood, Maureen ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Adrenocorticotropin; Blood pressure; Cortisol; Fetus

Indexed keywords

CORTICOTROPIN; CYCLOOXYGENASE 2; DIMETHYL SULFOXIDE; HYDROCORTISONE; NIMESULIDE; WATER;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BRAIN; BRAIN PERFUSION; CARDIOVASCULAR RESPONSE; CAROTID ARTERY; CONTROLLED STUDY; CORTICOTROPIN RELEASE; FEMORAL ARTERY; FETUS; FETUS HEART RATE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SHEEP;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BAROREFLEX; BLOOD PRESSURE; BRACHIOCEPHALIC TRUNK; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; FETAL BLOOD; GESTATIONAL AGE; HEART RATE, FETAL; HOMEOSTASIS; HYDROCORTISONE; HYPOTENSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFUSIONS, PARENTERAL; PITUITARY-ADRENAL SYSTEM; PRO-OPIOMELANOCORTIN; SHEEP; SULFONAMIDES;

EID: 67049088179     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90917.2008     Document Type: Article

References (42)

1. Adachi K, Umezaki H, Kaushal KM, Ducsay CA. Long-term hypoxia alters ovine fetal endocrine and physiological responses to hypotension. Am J Physiol Regul Integr Comp Physiol 287: R209-R217, 2004. (Pubitemid 38856329)
2. Adams J, Collaco-Moraes Y, de BJ. Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J Neurochem 66: 6-13, 1996. (Pubitemid 26010758)
3. Ali NS, Keller-Wood M, Wood CE. Ontogenetic changes in the extrapituitary expression of pro-opiomelanocortin in the developing ovine fetus. Peptides 26: 301-306, 2005. (Pubitemid 40051426)
4. Bell ME, Myers TR, Myers DA. Expression of proopiomelanocortin and prohormone convertase-1 and -2 in the late gestation fetal sheep pituitary. Endocrinology 139: 5135-5143, 1998. (Pubitemid 28533462)
5. Breder CD, DeWitt DL, Kraig RP. Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355: 296-315, 1995.
6. Breder CD, Smith WL, Raz A, Masferrer J, Seibert K, Needleman P, Saper CB. Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J Comp Neurol 322: 409-438, 1992.
7. Challis JR, Hart I, Louis TM, Mitchell MD, Jenkin G, Robinson JS, Thorburn GD. Prostaglandins in the sheep fetus: implications for fetal function. Adv Prostaglandin Thromboxane Res 4: 115-132, 1978.
8. Chen HG, Wood CE. The adrenocorticotropic hormone and arginine vasopressin responses to hypercapnia in fetal and maternal sheep. Am J Physiol Regul Integr Comp Physiol 264: R324-R330, 1993. (Pubitemid 23085893)
9. Cudd TA, Castro MI, Wood CE. Content, in vivo release, and bioactivity of fetal pulmonary immunoreactive adrenocorticotropin. Am J Physiol Endocrinol Metab 265: E667-E672, 1993. (Pubitemid 2006569)
10. Cudd TA, Wood CE. Secretion and clearance of immunoreactive ACTH by fetal lung. Am J Physiol Endocrinol Metab 268: E845-E848, 1995.
11. Cudd TA, Wood CE. Prostaglandin E2 releases ovine fetal ACTH from a site not perfused by the carotid vasculature. Am J Physiol Regul Integr Comp Physiol 263: R136-R140, 1992.
12. Deauseault D, Giroux D, Wood CE. Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus, and brainstem. Neuroendocrinology 71: 287-291, 2000. (Pubitemid 30312094)
13. Domoki F, Veltkamp R, Thrikawala N, Robins G, Bari F, Louis TM, Busija DW. Ischemia-reperfusion rapidly increases COX-2 expression in piglet cerebral arteries. Am J Physiol Heart Circ Physiol 277: H1207-H1214, 1999. (Pubitemid 29459636)
14. Edwards AV, Jones CT. The effect of splanchnic nerve section on the sensitivity of the adrenal cortex to adrenocorticotrophin in the calf. J Physiol 390: 23-31, 1987. (Pubitemid 17147844)
15. Edwards AV, Jones CT, Bloom SR. Reduced adrenal cortical sensitivity to ACTH in lambs with cut splanchnic nerves. J Endocrinol 110: 81-85, 1986. (Pubitemid 16057285)
16. Field A. Discovering Statistics Using SPSS. London: Sage Publications, 2005.
17. Gersting J, Schaub CE, Keller-Wood M, Wood CE. Inhibition of brain prostaglandin endoperoxide synthase-2 prevents the preparturient increase in fetal adrenocorticotropin secretion in the sheep fetus. Endocrinology 149: 4128-4136, 2008.
18. Jacobs RA, Young IR, Hollingworth SA, Thorburn GD. Chronic administration of low doses of adrenocorticotropin to hypophysectomized fetal sheep leads to normal term labor. Endocrinology 134: 1389-1394, 1994. (Pubitemid 24085595)
19. Jones SA, Adamson SL, Engelberts D, Bishai I, Norton J, Coceani F. PGE2 in the perinatal brain: local synthesis and transfer across the blood-brain barrier. J Lipid Mediat 6: 487-492, 1993.
20. Kimura Y, Okamura K, Watanabe T, Murotsuki J, Suzuki T, Yano M, Yajima A. Power spectral analysis for autonomic influences in heart rate and blood pressure variability in fetal lambs. Am J Physiol Heart Circ Physiol 271: H1333-H1339, 1996. (Pubitemid 26367009)
21. Li X, Tang D, Zhou S, Zhou G, Wang C, Zhuang Y, Wu G, Shen L. Redistribution of power spectrum of heart rate variability during acute umbilical artery embolism and hypoxemia in late-gestation fetal sheep. Eur J Obstet Gynecol Reprod Biol 114: 137-143, 2004. (Pubitemid 38622072)
22. Ment LR, Oh W, Ehrenkranz RA, Phillip AG, Vohr BR, Allen W, Duncan CC, Scott DT, Taylor KJW, Katz KH, Schneider KC, Makuch RW. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 93: 543-550, 1994. (Pubitemid 24106595)
23. Myers DA, Bell PA, Hyatt K, Mlynarczyk M, Ducsay CA. Long-term hypoxia enhances proopiomelanocortin processing in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol 288: R1178-R1184, 2005. (Pubitemid 40593700)
24. Myers DA, Robertshaw D, Nathanielsz PW. Effect of bilateral splanchnic nerve section on adrenal function in the ovine fetus. Endocrinology 127: 2328-2335, 1990. (Pubitemid 20381765)
25. Needleman P, Isakson PC. The discovery and function of COX-2. J Rheumatol 24 Suppl 49: 6-8, 1997.
26. Ohlsson A, Roberts RS, Schmidt B, Davis P, Moddeman D, Saigal S, Solimano A, Vincer M, Wright L. Male/female differences in indomethacin effects in preterm infants. J Pediatr 147: 860-862, 2005. (Pubitemid 41774850)
27. Powers MJ, Wood CE. Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion. Am J Physiol Regul Integr Comp Physiol 292: R1542-R1549, 2007. (Pubitemid 46557817)
28. Purinton SC, Wood CE. Oestrogen augments the fetal ovine hypothalamus- pituitary-adrenal axis in response to hypotension. J Physiol 544: 919-929, 2002. (Pubitemid 35355968)
29. Reimsnider S, Wood CE. Differential modulation of ovine fetal ACTH secretion by PGHS-1 and PGHS-2. Neuroendocrinology 83: 4-11, 2006. (Pubitemid 43877916)
30. Reimsnider SK, Wood CE. Does reduction of circulating prostaglandin E2 reduce fetal hypothalamic-pituitary-adrenal axis activity? J Soc Gynecol Investig 12: e13-e19, 2005. (Pubitemid 40615104)
31. Rudolph AM. Congenital diseases of the heart. Chicago: Year Book Medical Publishers, 1974.
32. Schaub CE, Keller-Wood M, Wood CE. Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep. Neuroendocrinology 87: 121-128, 2008.
33. Shalak L, Perlman JM. Hemorrhagic-ischemic cerebral injury in the preterm infant: current concepts. Clin Perinatol 29: 745-763, 2002. (Pubitemid 36076380)
34. Thorburn GD, Hollingworth SA, Hooper SB. The trigger for parturition in sheep: fetal hypothalamus or placenta? J Dev Physiol 15: 71-79, 1991.
35. Tong H, Dhillon H, Wood CE. Induction of PGHS-2 mRNA in response to cerebral hypoperfusion in late-gestation fetal sheep. Prostaglandins Other Lipid Mediat 62: 165-172, 2000. (Pubitemid 30628457)
36. Tong H, Lakhdir F, Wood CE. Endogenous prostanoids modulate the ACTH and AVP responses to hypotension in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol 275: R735-R741, 1998. (Pubitemid 28439818)
37. Tong H, Richards E, Wood CE. Prostaglandin endoperoxide synthase-2 abundance is increased in brain tissues of late-gestation fetal sheep in response to cerebral hypoperfusion. J Soc Gynecol Investig 6: 127-135, 1999. (Pubitemid 29264901)
38. Tong H, Wood CE. Indomethacin attenuates the cerebral blood flow response to hypotension in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol 277: R1268-R1273, 1999.
39. Vernikos J, Dallman MF, Bonner C, Katzen A, Shinsako J. Pituitary-adrenal function in rats chronically exposed to cold. Endocrinology 110: 413-420, 1982. (Pubitemid 12162931)
40. Wood CE, Barkoe D, The A, Newman H, Cudd TA, Purinton S, Castro MI. Fetal pulmonary immunoreactive adrenocorticotropin: molecular weight and cellular localization. Regul Pept 73: 191-196, 1998.
41. Wood CE, Chen HG. Acidemia stimulates ACTH, vasopressin, and heart rate responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol 257: R344-R349, 1989. (Pubitemid 19216969)
42. Wood CE, Giroux D. Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheep. J Physiol 549: 573-581, 2003. (Pubitemid 36701767)