An extract from Ricinus communis L. leaves possesses cytotoxic properties and induces apoptosis in SK-MEL-28 human melanoma cells

Natural Product Research

Volumn 23, Issue 6, 2009, Pages 561-571

  Darmanin, Stephanie ^a,b   Wismayer, Pierre Schembri ^a   Camilleri Podesta, Marie Therese ^a   Micallef, Mark J ^a   Buhagiar, Joseph A ^a  

^a UNIVERSITY OF MALTA   (Malta)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cytotoxicity; Ricinus communis L. (Euphorbiaceae); Terpenoids

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPHOR; CARYOPHYLLENE; CINEOLE; CYTOTOXIC AGENT; PHOSPHATIDYLSERINE; PINENE; RICINUS COMMUNIS EXTRACT; SESQUITERPENE DERIVATIVE; TERPENE; CYTOTOXIN; PLANT EXTRACT;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE; CELL NUCLEUS; CELL STRUCTURE; CELL SURFACE; CONTROLLED STUDY; DISTILLATION; DNA CONTENT; DRUG CYTOTOXICITY; EUPHORBIA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MASS FRAGMENTOGRAPHY; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PLANT LEAF; RICINUS COMMUNIS; STAINING; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ISOLATION AND PURIFICATION; PHASE CONTRAST MICROSCOPY; TUMOR CELL LINE;

DRYOBALANOPS; EUPHORBIACEAE; RICINUS COMMUNIS;

APOPTOSIS; CELL LINE, TUMOR; CYTOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MICROSCOPY, PHASE-CONTRAST; MONOTERPENES; PLANT EXTRACTS; PLANT LEAVES; RICINUS;

EID: 67049086961     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786410802228579     Document Type: Article

References (28)

1. Adams, R.P. (1995). Identification of essential oil components by gas chromatography/mass spectroscopy. Illinois: Allured Publishing.
2. Benn, P.A., & Tantravahi, U. (1992). Chromosome staining and banding techniques. In D.E. Rooney & B.H. Czepulkowski (Eds.), Human cytogenetics: A practical approach: Vol I. (pp. 96-98). USA: Oxford University Press.
3. Bigi, M.F.M.A., Torkomian, V.L.V., de Groote, S.T.C.S., Hebling, M.J.A., Bueno, O.C., Pagnocca, F.C., et al. (2004). Activity of Ricinus communis (Euphorbiaceae) and ricinine against the leafcutting ant Atta sexdens rubropilosa (Hymenoptera: Formicidae) and the symbiotic fungus Leucoagaricus gongylophorus. Pest Management Science, 60, 933-938.
4. Boje, K., Lechtenberg, M., & Nahrstedt, A. (2003). New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase. Planta Medica, 69(9), 820-825. (Pubitemid 37346569)
5. Boyd, M. (1997). The NCI in vitro anti-cancer drug discovery screen. In B.A. Teicher (Ed.), Anticancer drug development guide: Preclinical screening, clinical trials and approval (pp. 23-42). Totowa, NJ: Humana Press Inc.
6. British Herbal Medicine Association. (1990). British herbal pharmacopoeia (Vol. I, pp. 95-96). Dorset: British Herbal Medicine Association.
7. Buhagiar, J.A., Camilleri Podesta', M.T., Wilson, A.P., Micallef, M.J., & Ali, S. (1999). The induction of apoptosis in human melanoma, breast and ovarian cancer cell lines using an essential oil extract from the conifer Tetraclinis articulata. Anticancer Research, 19, 5435-5444.
8. Chevallier, A. (1996). The encyclopaedia of medicinal plants (p. 6, 260). London: Dorling Kindersley.
9. Cossarizza, A., Salvioli, S., Franceschini, M.G., Kalashnikova, G., Barberi, D., Monti, D., et al. (1995). Mitochondria and apoptosis: A cytofluorimetric approach. Fundamentals in Clinical Immunology, 3, 67-68.
10. Harborne, J.B. (1991). Recent advances in the ecological chemistry of plant terpenoids. In J.B. Harborne & F.A. Tomas-Barberan (Eds.), Ecological chemistry and biochemistry of plant terpenoids (pp. 399-426). Oxford: Clarendon Press.
11. Hohl, K.J. (1996). Monoterpenes as regulators of malignant cell proliferation. In American Institute of Cancer Research (Ed.), Dietary phytochemicals in cancer prevention and treatment (pp. 137-146). New York: Plenum Press.
12. Kaufman, D.C., & Chabner, B.A. (2001). Clinical strategies for cancer treatment: The role of drugs. In B.A. Chabner & D.L. Longo (Eds.), Cancer chemotherapy and biotherapy: Principles and practice (3rd ed., pp. 1-16). Philadelphia: Lippincott Williams & Wilkins.
13. Kaufmann, S.H., & Earnshaw, W.C. (2000). Induction of Apoptosis by Cancer Chemotherapy. Experimental Cell Research, 256, 42-49.
14. Kerr, J.F., Winterford, C.M., & Harmon, B.V. (1994). Apoptosis: Its significance in cancer and cancer therapy. Cancer, 73(8), 2013-2026. (Pubitemid 24107952)
15. Majno, G., & Joris, I. (1995). Apoptosis, oncosis, and necrosis. An overview of cell death. American Journal of Pathology, 146, 3-15.
16. Mo, H., & Elson, C.E. (1999). Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. Journal of Nutrition, 129, 804-813. (Pubitemid 129785917)
17. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1-2), 55-63.
18. Parkin, D.M., Whelan, S.L., Ferlay, J., & Storm, H. (2005). Cancer Incidence in Five Continents Vols. I to VIII. International Agency for Research on Cancer, Cancer Base No. 7, Lyon.
19. Ripple, G.H., Gould, M.N., Arzoomanian, R.Z., Alberti, D., Feierabend, C., Simon, K., et al. (2000). Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clinical Cancer Research, 6(2), 390-396. (Pubitemid 30111455)
20. Robbers, J.E., Speedie, M.K., & Tyler, V.E. (1996). Pharmacognosy and pharmacobiotechnology (pp. 1-14, 80-107). USA: Williams & Wilkins.
21. Schnell, R., Borchmann, P., Staak, J.O., Schindler, J., Ghetie, V., Vitetta, E.S., et al. (2003). Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma. Annals of Oncology, 14, 729-736. (Pubitemid 36621773)
22. Taraphdar, A.K.R.M., & Bhattacharya, R.K. (2001). Natural products as inducers of apoptosis: Implication for cancer therapy and prevention. Current Science, 80, 1387-1396.
23. Tatman, D., & Mo, H. (2001). Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukaemia cells. Cancer Letters, 175, 129-139. (Pubitemid 34001710)
24. Tequida-Meneses, M., Cortez-Rocha, M., Rosas-Burgos, E.C., Lopez-Sandoval, S., & Corrales-Maldonado, C. (2002). Effect of alcoholic extracts of wild plants on the inhibition of growth of Aspergillus flavus, Aspergillus niger, Penicillium chrysogenum, Penicillium expansum, Fusarium moniliforme and Fusarium poae moulds. Revista Iberoamericana de Micologia, 19(2), 84-88. (Pubitemid 34773795)
25. Vigushin, D.M., Poon, G.K., Boddy, A., English, J., Halbert, G.W., Pagonis, C., et al. (1998). Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Chemotherapy and Pharmacology, 42(2), 111-117. (Pubitemid 28267291)
26. Vitetta, E.S., Thorpe, P.E., & Uhr, J.W. (1993). Immunotoxins: Magic bullets or misguided missiles? Trends in Pharmacological Sciences, 14(5), 148-154.
27. Wang, Z., Chen, H.T., Roa, W., & Finlay, W. (2003). Farnesol for aerosol inhalation: Nebulisation and activity against human lung cancer cells. Journal of Pharmaceutical Sciences, 6(1), 95-100. (Pubitemid 37207244)
28. Yoshida, N., Takagi, A., Kitazawa, H., Kawakami, J., & Adachi, I. (2005). Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli fructus. Toxicology and Applied Pharmacology, 209(2), 167-173. (Pubitemid 41587406)