The T-cell receptor Vβ gene repertoire and clonal expansion from peripheral blood T cells in benzene-exposed workers in China

Hematology

Volumn 14, Issue 2, 2009, Pages 106-110

  Li, Bo ^a   Li, Yangqiu ^a,b   Chen, Shaohua ^a   Yang, Lijian ^a   Yu, Wei ^c   Chen, Jiayu ^c   Liu, Weiwei ^c  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c Twelfth Guangzhou People's Hospital   (China)

Author keywords

Benzene; Complementary determining region 3; T cell clonality; T cell receptor V gene

Indexed keywords

BENZENE; LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR VBETA CHAIN; T LYMPHOCYTE RECEPTOR VBETA CHAIN 16; T LYMPHOCYTE RECEPTOR VBETA CHAIN 21; T LYMPHOCYTE RECEPTOR VBETA CHAIN 3; T LYMPHOCYTE RECEPTOR VBETA CHAIN 6; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHINA; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; OCCUPATIONAL EXPOSURE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BENZENE; CELL LINE; CHINA; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; GENES, T-CELL RECEPTOR; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; YOUNG ADULT;

EID: 66949170716     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1179/102453309X385214     Document Type: Article

References (18)

1. Kenyon EM, Kraichely RE, Hudson KT, Medinsky MA. Differences in rates of benzene metabolism correlate with observed genotoxicity. Toxicol Appl Pharmacol 1996; 136: 49-56.
2. Aksoy M. Benzene as a leukemogenic and carcinogenic agent. Am J Ind Med 1985; 8: 9-20.
3. Ward E. Overview of preventable industrial causes of occupational cancer. Environ Health Perspect 1995; 103: 197-203.
4. Robinson SN, Shah R, Wong BA, Wong VA, Farris GM. Immunotoxicological effects of benzene inhalation in male Sprague-Dawley rats. Toxicology 1997; 119: 227-237.
5. Zeman K, Tchœrzewski H, Baj Z, Nowak Z, Majewska E, Pokoca L, Kocur E, Kantorski J. The effects of occupational exposure to hydrocarbons on some immune parameters of workers of the phenol division of a petrochemical plant. Pol J Occup Med 1990; 3: 399-407.
6. Joo WA, Sul D, Lee DY, Lee E, Kim CW. Proteomic analysis of plasma proteins of workers exposed to benzene. Mutat Res 2004; 558: 35-44.
7. Davis MM, Bjorkman PJ. T-cell antigen receptor gene and T-cell recognition. Nature 1988; 334: 395-402.
8. Pannetier C, Even J, Kourilsky P. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today 1995; 16: 176-181.
9. Li B, Li YQ, Yang LJ, Chen SH, Yu W, Liu WW, Chen JY. T-cell receptor Vα gene repertoire and clonal expansion in benzeneexposed workers. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007; 25: 590-593.
10. Genevée C, Diu A, Nierat J, Caignard A, Dietrich PY, Ferradini L, Roman-Roman S, Triebel F, Hercend T. An experimentally validated panel of subfamily-specific oligonucleotide primers (Valpha1-w29/Vbeta1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur J Immunol 1992; 22: 1261-1269
11. Yoshikai Y, Clark SP, Taylor S, Sohn U, Wilson BI, Minden MD, Mak TW. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor B chain. Proc Natl Acad Sci USA 1985; 82: 8624-8628.
12. Li Y, Chen S, Yang L, Yin Q, Geng S, Wu X, Schmidt CA, Przybylski GK. TRAV and TRBV repertoire, clonality and the proliferative history of umbilical cord blood T-cells. Transplant Immunol 2007; 18: 151-158.
13. Assaf C, Hummel M, Dippel E, Goerdt S, Müller HH. High detection rat of T-cell receptor beta chain rearrangements in T-cell lymphoproliferations by family specific polymerase chain reaction in combination with the GeneScan technique and DNA sequencing. Blood 2000; 96: 640-646.
14. Henderson RF, Sabourin PJ, Bechtold WE, Griffith WC, Medinsky MA, Birnbaum LS, Lucier GW. The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites. Environ Health Perspect 1989; 82: 9-17.
15. Hedli CC, Hoffmann MJ, Ji S, Thomas PE, Snyder R. Benzene metabolism in the isolated perfused mouse liver. Toxicol Appl Pharmacol 1997; 146: 60-68.
16. Clark BR. Fate of intercellular MHC-peptide-T-cell receptor complexes during T-cell activation. J Mol. Recog 1995; 8: 63-66
17. Weiss A, Irving BA, Tan LK, Koretzky GA. Signal transduction by the T cell antigen receptor. Semin Immunol 1991; 3: 313-324
18. Allison JP, Havran WL. The immunobiology of T cells with invariant gamma delta antigen receptors. Ann Rev Immunol 1991; 9: 679-705.