Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2β as biomarkers for rhabdomyosarcoma diagnostics

Histopathology

Volumn 54, Issue 7, 2009, Pages 873-879

  Grass, Beate ^c   Wachtel, Marco ^c   Behnke, Silvia ^a   Leuschner, Ivo ^b   Niggli, Felix K ^c   Schäfer, Beat W ^c,d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF KIEL   (Germany)

^c University Children's Hospital   (Switzerland)

^d UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

AP2 ; Diagnosis; EGFR; Fibrillin 2; P cadherin; Rhabdomyosarcoma

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRILLIN 2; P CADHERIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR AP 2 BETA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYONAL RHABDOMYOSARCOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOMA; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SENSITIVITY AND SPECIFICITY; TISSUE MICROARRAY; TUMOR BIOPSY;

ADAPTOR PROTEIN COMPLEX 2; ADAPTOR PROTEIN COMPLEX BETA SUBUNITS; CADHERINS; CHILD; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA; MALE; MICROFILAMENT PROTEINS; PREGNANCY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHABDOMYOSARCOMA; RHABDOMYOSARCOMA, ALVEOLAR; RHABDOMYOSARCOMA, EMBRYONAL; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 66949167418     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2009.03303.x     Document Type: Article

References (14)

1. Dantonello TM, Int-Veen C, Winkler P et al. Initial patient characteristics can predict pattern and risk of relapse in localized rhabdomyosarcoma. J. Clin. Oncol. 2008 26 406 413. (Pubitemid 351171692)
2. Sabattini E, Falini B, Pileri S. Rhabdomyosarcoma presenting as 'acute leukaemia'. Histopathology 1991 19 575 576.
3. Sandberg AA, Stone JF, Czarnecki L, Cohen JD. Hematologic masquerade of rhabdomyosarcoma. Am. J. Hematol. 2001 68 51 57. (Pubitemid 32738719)
4. Hanke CA, Roessler J, Stegmaier S, Koscielniak E, Niemeyer CM, Kontny U. Alveolar rhabdomyosarcoma mimicking lymphoma with bone marrow involvement. Eur. J. Pediatr. 2007 166 505 506. (Pubitemid 46450490)
5. Tsai SC, Reale LD, Flomenberg N, Schwarting R, Enck RE. Alveolar rhabdomyosarcoma mimicking a lymphoma at presentation. J. Clin. Oncol. 2006 24 4031 4032. (Pubitemid 46630756)
6. Cessna MH, Zhou H, Perkins SL et al. Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics Am. J. Surg. Pathol. 2001 25 1150 1157. (Pubitemid 32777714)
7. Wachtel M, Dettling M, Koscielniak E et al. Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. Cancer Res. 2004 64 5539 5545. (Pubitemid 39095545)
8. Wachtel M, Runge T, Leuschner I et al. Subtype and prognostic classification of rhabdomyosarcoma by immunohistochemistry. J. Clin. Oncol. 2006 24 816 822. (Pubitemid 46622049)
9. Ganti R, Skapek SX, Zhang J et al. Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma. Mod. Pathol. 2006 19 1213 1220. (Pubitemid 44268191)
10. Barr FG, Qualman SJ, Macris MH et al. Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions. Cancer Res. 2002 62 4704 4710. (Pubitemid 34898599)
11. Davicioni E, Finckenstein FG, Shahbazian V, Buckley JD, Triche TJ, Anderson MJ. Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas. Cancer Res. 2006 66 6936 6946. (Pubitemid 44197668)
12. Lae M, Ahn EH, Mercado GE et al. Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas. J. Pathol. 2007 212 143 151. (Pubitemid 46852092)
13. Ebauer M, Wachtel M, Niggli FK, Schafer BW. Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR. Oncogene 2007 26 7267 7281. (Pubitemid 350085317)
14. Kurtin PJ, Pinkus GS. Leukocyte common antigen - a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization. Hum. Pathol. 1985 16 353 365. (Pubitemid 15071532)