Effects of two-months Nigella sativa supplementation on cardiac hemodynamics and adrenergic responsiveness

Journal of the Pakistan Medical Association

Volumn 59, Issue 6, 2009, Pages 363-367

  Al Hariri, Mohammad Taha ^a   Yar, Talay ^a   Bamosa, Abdullah Omar ^a   El Bahai, Mohammad Nabil ^a  

^a IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPRENALINE; NIGELLA SATIVA EXTRACT; CARDIOTONIC AGENT; PLANT EXTRACT;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; CALCULATION; CARDIAC PRESSURE RATE PRODUCT; CHRONOTROPISM; CONTROLLED STUDY; DRUG EFFECT; HEART HEMODYNAMICS; HEART MUSCLE TENSION; HEART PERFORMANCE; HEART RATE; HEART WORK; IN VITRO STUDY; IN VIVO STUDY; INOTROPISM; ISOLATED HEART; LONG TERM CARE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PARAMETER; RAT; SUPPLEMENTATION; TENSION RATE PRODUCT; ANIMAL; CHEMISTRY; DIET SUPPLEMENTATION; DRUG EFFECTS; HEART CONTRACTION; HEMODYNAMICS; PERFUSION; WISTAR RAT;

ANIMALS; CARDIOTONIC AGENTS; DIETARY SUPPLEMENTS; HEART RATE; HEMODYNAMICS; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; NIGELLA SATIVA; PERFUSION; PLANT EXTRACTS; RATS; RATS, WISTAR; IN VITRO TECHNIQUES;

EID: 66949151772     PISSN: 00309982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Wakatsuki T, Schlessinger J, Elson EL. The biochemical response of the heart to hypertension and exercise. Trends Biochem Sci 2004; 29: 609-617 (Pubitemid 39389081)
2. Morisco C, Sadoshima J, Trimarco B, Arora R, Vatner DE, Vatner SF. Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol 2003; 284: H1043-7. (Pubitemid 36348563)
3. Tarone G, Lembo G. Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy. Trends Mol Med 2003; 9: 376-382 (Pubitemid 37169051)
4. Carroll JF, Jones AE, Hester RL, Reinhart GA, Cockrell K, Mizelle HL. Reduced cardiac contractile responsiveness to isoproterenol in obese rabbits. Hypertension 1997; 30: 1376-1381 (Pubitemid 27528078)
5. DiBianco R. Update on therapy for heart failure. Am J Med 2003; 115: 480-488 (Pubitemid 37237562)
6. Gilani AH, Aziz N, Khurram IM, Chaudhary KS, Iqbal A. Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses. J Pak Med Assoc 2001; 51:115-120 (Pubitemid 32441247)
7. El Tahir KE, Ashour MM, al Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 24: 1123-1131
8. Boskabady MH, Shafei MN, Parsaee H. Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity. Pharmazie 2005; 60: 943-948 (Pubitemid 41820763)
9. El-Bahai MN, Al-Hariri MT, Yar T, Bamosa AO. Cardiac Inotropic and Hypertrophic Effects of Nigella sativa Supplementation in Rats. Int J Cardiol 2009; 131: e115-7.
10. McConville P, Spencer RG, Lakatta EG. Temporal dynamics of inotropic, chronotropic, and metabolic responses during beta1- and beta2-AR stimulation in the isolated, perfused rat heart. Am J Physiol Endocrinol Metab 2005; 289:E412-8. (Pubitemid 41192696)
11. Zheng M, Han QD, Xiao RP. Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Sheng Li Xue Bao 2004; 56: 1-15.
12. Hammond HK, White FC, Buxton IL, Saltzstein P, Brunton LL, Longhurst JC. Increased myocardial beta-receptors and adrenergic responses in hyperthyroid pigs. Am J Physiol 1987; 252: H283-90. (Pubitemid 17053097)
13. Serneri GG, Boddi M, Cecioni I, Vanni S, Coppo M, Papa ML et al. Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function. Circ Res 2001; 88: 961-968 (Pubitemid 32441476)
14. Meral I, Yener Z, Kahraman T, Mert N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet Med A Physiol Pathol Clin Med 2001; 48: 593-599 (Pubitemid 33637447)
15. Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, Hassar M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000; 55: 379-382
16. Mann DL, Kent RL, Parsons B, Cooper G. Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 1992; 85: 790-804.
17. Communal C, Ribuot C, Durand A, Demenge P. Myocardial beta-adrenergic reactivity in pressure overload-induced cardiac hypertrophy in the rat. Fundam Clin Pharmacol 1998; 12: 590-598 (Pubitemid 29535481)
18. Haggendal J, Jonsson L, Johansson G, Bjurstrom S, Carlsten J, Thoren-Tolling K. Catecholamine-induced free radicals in myocardial cell necrosis on experimental stress in pigs. Acta Physiol Scand 1987; 131: 447-452 (Pubitemid 18066310)
19. Pearson RM, van der Valk-Kokshoorn EJ, Egas-Kenniphaas JM, Mauve I, van der LA. Isoproterenol-induced cytotoxicity in neonatal rat heart cell cultures is mediated by free radical formation. J Mol Cell Cardiol 1989; 21: 1285-1291 (Pubitemid 20046103)
20. Ko W, Zelano JA, Fahey AL, Berman K, Lang D, Isom OW et al. The effects of amrinone versus dobutamine on myocardial mechanics and energetics after hypothermic global ischemia. J Thorac Cardiovasc Surg 1993; 105: 1015-1024 (Pubitemid 23178832)
21. Zhou Z, Lasley RD, Hegge JO, Bunger R, Mentzer RM Jr. Myocardial stunning: a therapeutic conundrum. J Thorac Cardiovasc Surg 1995; 110: 1391-1400
22. Suga H, Hisano R, Goto Y, Yamada O, Igarashi Y. Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure volume area in canine left ventricle. Circ Res 1983; 53: 306-318
23. Mittmann C, Eschenhagen T, Scholz H. Cellular and molecular aspects of contractile dysfunction in heart failure. Cardiovasc Res 1998; 39: 267-275 (Pubitemid 28346522)
24. Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 2003; 65: 45-79. (Pubitemid 38249147)