New derivatives of ascomycin with modifications in the amino acid region - Synthesis and biological activities, and X-ray crystal structure of 5,6-dehydroascomycin

Helvetica Chimica Acta

Volumn 92, Issue 5, 2009, Pages 839-889

  Bulusu, Murty A R C ^a,c   Waldstätten, Peter ^a   Tricotet, Thomas ^a   Rochais, Christophe ^a   Steck, Andrea ^a,d   Bacher, Markus ^a,d   Schulz, Gerhard ^a   Meingassner, Josef G ^a   Hiestand, Peter ^b   Zenke, Gerhard ^b   Schuler, Walter ^b   Wagner, Trixie ^b  

^a Novartis Institutes for Biomedical Research GmbH and Co KG   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Nabriva Therapeutics Inc   (Austria)

^d Bruker Analytical Services Austria (Bruker Austria GmbH)   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACID MOIETY; ACID REGION; AMIDE BOND; ATOPIC DERMATITIS; BIOLOGICAL ACTIVITIES; CALCINEURIN; CLEAVAGE PRODUCTS; CONTACT DERMATITIS; IN-VITRO; MACROLIDE; METHOXY; NEW APPROACHES; OXAZOLIDINONE; PHOTOCHEMICAL CLEAVAGE; PHOTOREACTION; ROUTINE METHOD; T CELL ACTIVATION; TACROLIMUS; TOPICAL TREATMENTS; X RAY CRYSTAL STRUCTURES;

AMIDES; AMINATION; AMINES; AMINO ACIDS; BIOACTIVITY; CRYSTAL STRUCTURE; DERIVATIVES; DERMATITIS; ORGANIC ACIDS; PHOTOCHEMICAL REACTIONS; SYNTHESIS (CHEMICAL);

CHEMICAL MODIFICATION;

5,6 DEHYDROASCOMYCIN; 6 BETA METHOXYASCOMYCIN; AMIDE; AMINO ACID; ASCOMYCIN; CLOBETASOL PROPIONATE; FLUTICASONE PROPIONATE; IMMUNOSUPPRESSIVE AGENT; OXAZOLIDINONE DERIVATIVE; PIPECOLIC ACID DERIVATIVE; PROLINE DERIVATIVE; SOLVENT; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL BOND; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; IRRADIATION; KIDNEY GRAFT REJECTION; MOUSE; NONHUMAN; PHOTOREACTIVITY; PRIORITY JOURNAL; RAT; RISK; SKIN ALLERGY; X RAY CRYSTALLOGRAPHY;

EID: 66949142648     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200800436     Document Type: Article

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