Frontiers and controversies in the pathobiology of vitiligo: Separating the wheat from the chaff

Experimental Dermatology

Volumn 18, Issue 7, 2009, Pages 583-585

  Boissy, Raymond E ^a   Spritz, Richard A ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Leukoderma; Melanocytes; Pigmentation

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA ANTIGEN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CALCIUM DEFICIENCY; CELL ACTIVATION; CELL DEATH; DENDRITIC CELL; ENVIRONMENTAL FACTOR; GENETIC DISORDER; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; MELANOCYTE; PATHOGENESIS; PROTEIN EXPRESSION; SKIN INJURY; SUNBURN; VITILIGO;

AUTOIMMUNE DISEASES; CALCIUM; HUMANS; MELANOCYTES; REACTIVE OXYGEN SPECIES; SKIN PIGMENTATION; VITILIGO;

EID: 66949135453     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2008.00826.x     Document Type: Article

References (20)

1. Schallreuter K U, Bahadoran P, Picardo M et.al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 2008: 17: 139-140.
2. Nordlund J J, Ortonne J-P, Le Poole I C. Vitiligo vulgaris. In: Nordlund J J, Boissy R E, Hearing V J, King R A, Oetting W S, Ortonne J-P, eds. The Pigmentary System. Malden, MA: Blackwell, 2006: 551-598.
3. Spritz R A. The genetics of generalized vitiligo. Curr Opin Autoimmun 2008: 10: 244-257.
4. Freedman M L, Reich D, Penney K L et al. Assessing the impact of population stratification on genetic association studies. Nat Genet 2004: 36: 388-393.
5. Ongenae K, Van Geel N, Naeyeert J M. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res 2003: 16: 90-100.
6. Le Poole I C, Luiten R M. Autoimmune etiolgy of generalized vitiligo. Curr Dir Autoimmun 2008: 10: 227-243.
7. Alkhateeb A, Fain P R, Thody A, Bennett D C, Spritz R A. Epidemiology of vitiligo and associated autoimmune diseases in caucasian probands and their families. Pigment Cell Res 2003: 16: 208-214.
8. Laberge G, Mailloux C M, Gowan K et al. Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo. Pigment Cell Res 2005: 18: 300-305.
9. Kroll T M, Bommiasamy H, Boissy R E, Nickoloff B J, Mestril R, Le Poole I C. 4-Tertiary butyl phenol exposure sensitizes melanocytes to dendritic cell mediated killing. J Invest Dermatol 2005: 124: 798-806.
10. Neumeister P, Strunk D, Apfelbeck U, Sill H, Linkesch W. Adoptive transfer of vitiligo after allogeneic bone marrow transplantation for non-Hodgkin's lymphoma. Lancet 2000: 355: 1334-1335.
11. Alajlan A, Alfadley A, Pedersen K T. Transfer of vitiligo after allogeneic bone marrow transplantation. J Am Acad Dermatol 2002: 46: 606-610.
12. Mahoney J A, Rosen A. Apoptosis and autoimmunity. Curr Opin Immunol 2005: 17: 583-588.
13. Gauthier Y, Andre M C, Taïeb A. A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? Pigment Cell Res 2003: 16: 322-332.
14. Dell'anna M L, Picardo M. A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. Pigment Cell Res 2006: 19: 406-411.
15. Boissy R E, Manga P. On the etiology of contact/occupational vitiligo. Pigment Cell Res 2004: 17: 208-214.
16. Manga P, Sheyn D, Yang F, Sarangarajan R, Boissy R E. A role for tyrosinase related-protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes. Implications for vitiligo. Am J Pathol 2006: 169: 1652-1662.
17. Sturm R A. Human pigmentation genes and their response to solar UV radiation. Mutat Res 1998: 422: 69-76.
18. Land E J, Ramsden C A, Riley P A. Toxicological aspects of melanin and melanogenesis. In: Nordlund J J, Boissy R E, Hearing V J, King R A, Oetting W S, Ortonne J-P, eds. The Pigmentary System. Malden, MA: Blackwell, 2006: 354-394.
19. Meyskens F L Jr, Farmer P, Fruehauf J P. Redox regulation in human melanocytes and melanoma. Pigment Cell Res 2001: 14: 148-154.
20. Marshall B J, Warren J R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984: 1: 1311-1315.