Split-liver transplantation in the high-MELD adult patient: Are we being too cautious?

Transplant International

Volumn 22, Issue 7, 2009, Pages 702-706

  Nadalin, Silvio ^a,d   Schaffer, Randolph ^b   Fruehauf, Nils ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b SCRIPPS CLINIC   (United States)

^c German Foundation of Organ Transplantation (DSO)   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Liver; MELD; Split; Transplantation

Indexed keywords

ADULT; ARTICLE; CHRONIC LIVER DISEASE; CONTROLLED STUDY; GRAFT SURVIVAL; HUMAN; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; ORGAN DONOR; PRIORITY JOURNAL; SCORING SYSTEM; SURGICAL TECHNIQUE;

ADULT; DATABASES, FACTUAL; GRAFT SURVIVAL; HUMANS; LIVER; LIVER FAILURE; LIVER TRANSPLANTATION; MODELS, THEORETICAL; TIME FACTORS; TISSUE AND ORGAN PROCUREMENT; TRANSPLANTS; TREATMENT OUTCOME;

EID: 66949122510     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2009.00850.x     Document Type: Article

References (29)

1. Renz JF, Yersiz H, Reichert PR, et al. Split-liver transplantation: a review. Am J Transplant 2003 3 : 1323.
2. Fruhauf NR, Malago M, Frilling A, Beckebaum S, Broelsch CE. Latest development in split liver transplantation. Surg Technol Int 2004 13 : 183.
3. Malago M, Hertl M, Testa G, Rogiers X, Broelsch CE. Split-liver transplantation: future use of scarce donor organs. World J Surg 2002 26 : 275.
4. Cardillo M, De Fazio N, Pedotti P, et al. Split and whole liver transplantation outcomes: a comparative cohort study. Liver Transpl 2006 12 : 402.
5. Malinchoc M, Kamath PS, Gordon FD, Peine CJ, Rank J, ter Borg PC. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology (Baltimore, Md 2000 31 : 864.
6. Northup PG, Wanamaker RC, Lee VD, Adams RB, Berg CL. Model for End-Stage Liver Disease (MELD) predicts nontransplant surgical mortality in patients with cirrhosis. Ann Surg 2005 242 : 244.
7. Cucchetti A, Ercolani G, Vivarelli M, et al. Impact of model for end-stage liver disease (MELD) score on prognosis after hepatectomy for hepatocellular carcinoma on cirrhosis. Liver Transpl 2006 12 : 966.
8. Xia VW, Du B, Braunfeld M, et al. Preoperative characteristics and intraoperative transfusion and vasopressor requirements in patients with low vs. high MELD scores. Liver Transpl 2006 12 : 614.
9. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology (Baltimore, Md 2001 33 : 464.
10. Freeman RB Jr., Wiesner RH, Harper A, et al. The new liver allocation system: moving toward evidence-based transplantation policy. Liver Transpl 2002 8 : 851.
11. Wiesner R, Edwards E, Freeman R, et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003 124 : 91.
12. Olthoff KM, Brown RS Jr., Delmonico FL, et al. Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. December 8, 2003, Washington, DC, USA. Liver Transpl 2004 10 : A6.
13. Schaffer RL III., Kulkarni S, Harper A, Millis JM, Cronin DC II. The sickest first? Disparities with model for end-stage liver disease-based organ allocation: one region's experience. Liver Transpl 2003 9 : 1211.
14. Washburn K, Halff G, Mieles L, Goldstein R, Goss JA. Split-liver transplantation: results of statewide usage of the right trisegmental graft. Am J Transplant 2005 5 : 1652.
15. Loss M, Obed A, Schlitt HJ. Split-liver transplantation. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2008 79 : 144.
16. Schaubel DE, Sima CS, Goodrich NP, Feng S, Merion RM. The survival benefit of deceased donor liver transplantation as a function of candidate disease severity and donor quality. Am J Transplant 2008 8 : 419.
17. Biggins SW. Beyond the numbers: rational and ethical application of outcome models for organ allocation in liver transplantation. Liver Transpl 2007 13 : 1080.
18. Burroughs AK, Sabin CA, Rolles K, et al. 3-month and 12-month mortality after first liver transplant in adults in Europe: predictive models for outcome. Lancet 2006 367 : 225.
19. Merion RM, Rush SH, Dykstra DM, Goodrich N, Freeman RB Jr., Wolfe RA. Predicted lifetimes for adult and pediatric split liver versus adult whole liver transplant recipients. Am J Transplant 2004 4 : 1792.
20. Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006 6 : 783.
21. Bonney GK, Aldouri A, Attia M, et al. Outcomes in right liver lobe transplantation: a matched pair analysis. Transpl Int 2008 21 : 1045.
22. Ikegami T, Taketomi A, Soejima Y, et al. Living donor liver transplantation for acute liver failure: a 10-year experience in a single center. J Am Coll Surg 2008 206 : 412.
23. Broering DC, Topp S, Schaefer U, et al. Split liver transplantation and risk to the adult recipient: analysis using matched pairs. J Am Coll Surg 2002 195 : 648.
24. Humar A, Beissel J, Crotteau S, Kandaswamy R, Lake J, Payne W. Whole liver versus split liver versus living donor in the adult recipient: an analysis of outcomes by graft type. Transplantation 2008 85 : 1420.
25. Sainz-Barriga M, Ricciardi S, Haentjens I, et al. Split liver transplantation with extended right grafts under patient-oriented allocation policy. Single center matched-pair outcome analysis. Clin Transplant 2008 22 : 447.
26. Sebagh M, Yilmaz F, Karam V, et al. Cadaveric full-size liver transplantation and the graft alternatives in adults: a comparative study from a single centre. J Hepatol 2006 44 : 118.
27. Wilms C, Walter J, Kaptein M, et al. Long-term outcome of split liver transplantation using right extended grafts in adulthood: A matched pair analysis. Ann Surg 2006 244 : 865, discussion 72-3.
28. Yersiz H, Renz JF, Farmer DG, Hisatake GM, McDiarmid SV, Busuttil RW. One hundred in situ split-liver transplantations: a single-center experience. Ann Surg 2003 238 : 496, discussion 6-7.
29. Becker T, Takabe A, Schrem H, et al. Extended right liver grafts by ex situ split can be used safely for primary and secondary transplantation in adults with acceptable biliary morbidity. Transplantationsmedizin 2008 Suppl. II : 94.