-
1
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
2
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
3
-
-
76749105404
-
Phase III, randomised, open-label
-
Stockholm, Sweden, September 12-16
-
Mok T, Wu Y-L, Thongprasert S, et al: Phase III, randomised, open-label, firstline study of gefitinib vs carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer (IPASS). The 33rd European Society for Medical Oncology Congress, Stockholm, Sweden, September 12-16, 2008
-
(2008)
firstline study of gefitinib vs carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer (IPASS). The 33rd European Society for Medical Oncology Congress
-
-
Mok, T.1
Wu, Y.-L.2
Thongprasert, S.3
-
4
-
-
33947498978
-
Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
-
Sequist LV, Bell DW, Lynch TJ, et al: Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 25:587-595, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 587-595
-
-
Sequist, L.V.1
Bell, D.W.2
Lynch, T.J.3
-
5
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, et al: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352:786-792, 2005
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
6
-
-
18244371651
-
-
Pao W, Miller VA, Politi KA, et al: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoSMed 2:e73, 2005
-
Pao W, Miller VA, Politi KA, et al: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoSMed 2:e73, 2005
-
-
-
-
7
-
-
28444478439
-
Oncogenic transformation by inhibitorsensitive and -resistant EGFR mutants
-
Greulich H, Chen TH, Feng W, et al: Oncogenic transformation by inhibitorsensitive and -resistant EGFR mutants. PLoS Med 2:e313, 2005
-
(2005)
PLoS Med
, vol.2
-
-
Greulich, H.1
Chen, T.H.2
Feng, W.3
-
8
-
-
34250161814
-
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/ phospho-Aktpositive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial
-
Cappuzzo F, Ligorio C, Janne PA, et al: Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/ phospho-Aktpositive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial. J Clin Oncol 25:2248-2255, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 2248-2255
-
-
Cappuzzo, F.1
Ligorio, C.2
Janne, P.A.3
-
9
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al: MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316:1039-1043, 2007
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
10
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al: MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104:20932-20937, 2007
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
11
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 101:13306-13311, 2004
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
12
-
-
33746061252
-
A blood-based test for epidermal growth factor receptor mutations in lung cancer
-
Bell DW, Haber DA: A blood-based test for epidermal growth factor receptor mutations in lung cancer. Clin Cancer Res 12:3875-3877, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3875-3877
-
-
Bell, D.W.1
Haber, D.A.2
-
13
-
-
34250880807
-
Detection of epidermal growth factor receptor mutation in transbronchial needle aspirates of non-small cell lung cancer
-
Horiike A, Kimura H, Nishio K, et al: Detection of epidermal growth factor receptor mutation in transbronchial needle aspirates of non-small cell lung cancer. Chest 131:1628-1634, 2007
-
(2007)
Chest
, vol.131
, pp. 1628-1634
-
-
Horiike, A.1
Kimura, H.2
Nishio, K.3
-
14
-
-
34548849132
-
Epidermal growth factor receptor mutation testing in lung cancer: Searching for the ideal method
-
Pao W, Ladanyi M: Epidermal growth factor receptor mutation testing in lung cancer: Searching for the ideal method. Clin Cancer Res 13:4954-4955, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4954-4955
-
-
Pao, W.1
Ladanyi, M.2
-
15
-
-
33746877875
-
Epidermal growth factor receptor mutation testing in the care of lung cancer patients
-
Sequist LV, Joshi VA, Janne PA, et al: Epidermal growth factor receptor mutation testing in the care of lung cancer patients. Clin Cancer Res 12:4403s-4408s, 2006
-
(2006)
Clin Cancer Res
, vol.12
-
-
Sequist, L.V.1
Joshi, V.A.2
Janne, P.A.3
-
16
-
-
66849091226
-
Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stage IIIB to IV non-small-cell lung cancer
-
Bai H, Mao L, Wang HS, et al: Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stage IIIB to IV non-small-cell lung cancer. J Clin Oncol 27:2653-2659, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 2653-2659
-
-
Bai, H.1
Mao, L.2
Wang, H.S.3
-
17
-
-
32944468710
-
A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening
-
Janne PA, Borras AM, Kuang Y, et al: A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening. Clin Cancer Res 12:751-758, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 751-758
-
-
Janne, P.A.1
Borras, A.M.2
Kuang, Y.3
-
18
-
-
33845572242
-
Evaluation of denaturing high-performance liquid chromatography as a rapid detection method for identification of epidermal growth factor receptor mutations in nonsmall-cell lung cancer
-
Cohen V, Agulnik JS, Jarry J, et al: Evaluation of denaturing high-performance liquid chromatography as a rapid detection method for identification of epidermal growth factor receptor mutations in nonsmall-cell lung cancer. Cancer 107:2858-2865, 2006
-
(2006)
Cancer
, vol.107
, pp. 2858-2865
-
-
Cohen, V.1
Agulnik, J.S.2
Jarry, J.3
-
19
-
-
33845989517
-
Detection of epidermal growth factor receptor variations by partially denaturing HPLC
-
Chin TM, Anuar D, Soo R, et al: Detection of epidermal growth factor receptor variations by partially denaturing HPLC. Clin Chem 53:62-70, 2007
-
(2007)
Clin Chem
, vol.53
, pp. 62-70
-
-
Chin, T.M.1
Anuar, D.2
Soo, R.3
-
20
-
-
20244388126
-
Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
-
Mitsudomi T, Kosaka T, Endoh H, et al: Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 23:2513-2520, 2005
-
(2005)
J Clin Oncol
, vol.23
, pp. 2513-2520
-
-
Mitsudomi, T.1
Kosaka, T.2
Endoh, H.3
-
21
-
-
23844490782
-
Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
-
Taron M, Ichinose Y, Rosell R, et al: Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res 11:5878-5885, 2005
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5878-5885
-
-
Taron, M.1
Ichinose, Y.2
Rosell, R.3
-
22
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, et al: First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 26:2442-2449, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
-
23
-
-
53949092103
-
Molecular and clinical subgroup analyses from a phase III trial comparing gefitinib with docetaxel in previously treated non-small cell lung cancer (INTEREST)
-
suppl; abstr 8001, 424s
-
Douillard JY, Hirsh V, Mok T, et al: Molecular and clinical subgroup analyses from a phase III trial comparing gefitinib with docetaxel in previously treated non-small cell lung cancer (INTEREST). J Clin Oncol 26:424s, 2008 (suppl; abstr 8001)
-
(2008)
J Clin Oncol
, vol.26
-
-
Douillard, J.Y.1
Hirsh, V.2
Mok, T.3
-
24
-
-
33746100318
-
Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-smallcell lung cancer
-
Kimura H, Kasahara K, Kawaishi M, et al: Detection of epidermal growth factor receptor mutations in serum as a predictor of the response to gefitinib in patients with non-smallcell lung cancer. Clin Cancer Res 12:3915-3921, 2006
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3915-3921
-
-
Kimura, H.1
Kasahara, K.2
Kawaishi, M.3
-
25
-
-
34548593298
-
Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA)
-
Kimura H, Suminoe M, Kasahara K, et al: Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA). Br J Cancer 97:778-784, 2007
-
(2007)
Br J Cancer
, vol.97
, pp. 778-784
-
-
Kimura, H.1
Suminoe, M.2
Kasahara, K.3
-
26
-
-
74949112609
-
High correspondence between EGFR mutations in tissue and in circulating DNA from non-small-cell lung cancer (NSCLC) patients with poor performance status (PS)
-
suppl; abstr 7505, 386s
-
Moran T, Pas-Ares L, Isla D, et al: High correspondence between EGFR mutations in tissue and in circulating DNA from non-small-cell lung cancer (NSCLC) patients with poor performance status (PS). J Clin Oncol 25:386s, 2007 (suppl; abstr 7505)
-
(2007)
J Clin Oncol
, vol.25
-
-
Moran, T.1
Pas-Ares, L.2
Isla, D.3
-
27
-
-
37549002543
-
Isolation of rare circulating tumour cells in cancer patients by microchip technology
-
Nagrath S, Sequist LV, Maheswaran S, et al: Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450:1235-1239, 2007
-
(2007)
Nature
, vol.450
, pp. 1235-1239
-
-
Nagrath, S.1
Sequist, L.V.2
Maheswaran, S.3
-
28
-
-
47949114668
-
Detection of mutations in EGFR in circulating lung-cancer cells
-
Maheswaran S, Sequist LV, Nagrath S, et al: Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359:366-377, 2008
-
(2008)
N Engl J Med
, vol.359
, pp. 366-377
-
-
Maheswaran, S.1
Sequist, L.V.2
Nagrath, S.3
-
29
-
-
33746789922
-
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
-
Inoue A, Suzuki T, Fukuhara T, et al: Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 24:3340-3346, 2006
-
(2006)
J Clin Oncol
, vol.24
, pp. 3340-3346
-
-
Inoue, A.1
Suzuki, T.2
Fukuhara, T.3
-
30
-
-
33750205340
-
A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
-
Asahina H, Yamazaki K, Kinoshita I, et al: A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer 95:998-1004, 2006
-
(2006)
Br J Cancer
, vol.95
, pp. 998-1004
-
-
Asahina, H.1
Yamazaki, K.2
Kinoshita, I.3
-
31
-
-
33845434121
-
A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR)
-
suppl; abstr 7020, 369s
-
Paz-Ares L, Sanchez JM, Garcia-Velasco A, et al: A prospective phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR). J Clin Oncol 24:369s, 2006 (suppl; abstr 7020)
-
(2006)
J Clin Oncol
, vol.24
-
-
Paz-Ares, L.1
Sanchez, J.M.2
Garcia-Velasco, A.3
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