Renal thrombotic microangiopathy after hematopoietic cell transplant: Role of GVHD in pathogenesis

Clinical Journal of the American Society of Nephrology

Volumn 4, Issue 2, 2009, Pages 345-353

  Changsirikulchai, Siribha ^a   Myerson, David ^b,d   Guthrie, Katherine A ^d   McDonald, George B ^b,d   Alpers, Charles E ^b   Hingorani, Sangeeta R ^c  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMPHOTERICIN; CYCLOSPORIN A; HLA ANTIGEN; TACROLIMUS;

ACUTE GRAFT VERSUS HOST DISEASE; ADENOVIRUS; ADULT; AGE; APLASTIC ANEMIA; ARTICLE; AUTOPSY; CONTROLLED STUDY; CYTOMEGALOVIRUS; DEATH; DIALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DONOR; FEMALE; GRAFT INFECTION; GRAFT RECIPIENT; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; HLA MATCHING; HUMAN; HUMAN TISSUE; KIDNEY FAILURE; KIDNEY PARENCHYMA; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; PREVALENCE; RADIATION DOSE; SEX DIFFERENCE; THROMBOTIC THROMBOCYTOPENIC PURPURA; VARICELLA ZOSTER VIRUS; WHOLE BODY RADIATION; ADENOVIRUS INFECTION; ADOLESCENT; AGED; CHILD; GRAFT VERSUS HOST REACTION; HOSPITALIZATION; INFANT; KIDNEY; KIDNEY DISEASE; MIDDLE AGED; MORTALITY; PATHOLOGY; PRESCHOOL CHILD; RISK; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; THROMBOCYTOPENIA; THROMBOSIS;

ADENOVIRIDAE INFECTIONS; ADOLESCENT; ADULT; AGED; AUTOPSY; CHILD; CHILD, PRESCHOOL; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFANT; KIDNEY; KIDNEY DISEASES; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PREVALENCE; RADIATION DOSAGE; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; THROMBOCYTOPENIA; THROMBOSIS; YOUNG ADULT;

EID: 66849128214     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.02070508     Document Type: Article

References (35)

1. Fogo AB: The role of angiotensin ii and plasminogen activator inhibitor-1 in progressive glomerulosclerosis. Am J Kidney Dis 35: 179-188, 2000 (Pubitemid 30070837)
2. Ruggenenti P, Noris M, Remuzzi G: Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int 60: 831-846, 2001 (Pubitemid 34205784)
3. van der Plas RM, Schiphorst ME, Huizinga EG, Hene RJ, Verdonck LF, Sixma JJ, Fijnheer R: Von Willebrand factor proteolysis is deficient in classic, but not in bone marrow transplantation-associated, thrombotic thrombocytopenic purpura. Blood 93: 3798-3802, 1999
4. Fuge R, Bird JM, Fraser A, Hart D, Hunt L, Cornish JM, Goulden N, Oakhill A, Pamphilon DH, Steward CG, Marks DI: The clinical features, risk factors and outcome of thrombotic thrombocytopenic purpura occurring after bone marrow transplantation. Br J Haematol 113: 58-64, 2001 (Pubitemid 32423303)
5. Paquette RL, Tran L, Landaw EM: Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft-versus-host disease prophylaxis. Bone Marrow Transplant 22: 351-357, 1998 (Pubitemid 28401075)
6. Uderzo C, Fumagalli M, De Lorenzo P, Busca A, Vassallo E, Bonanomi S, Lanino E, Dini G, Varotto S, Messina C, Miniero R, Valsecchi MG, Balduzzi A: Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing bone marrow transplantation. Bone Marrow Transplant 26: 1005-1009, 2000
7. Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE, Lerner KG, Glucksberg H, Buckner CD: Bone-marrow transplantation. N Engl J Med 292: 895-902, 1975
8. Nakamae H, Yamane T, Hasegawa T, Nakamae M, Terada Y, Hagihara K, Ohta K, Hino M: Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation. Am J Hematol 81: 525-531, 2006
9. Daly AS, Hasegawa WS, Lipton JH, Messner HA, Kiss TL: Transplantation-associated thrombotic microangiopathy is associated with transplantation from unrelated donors, acute graft-versus-host disease and venoocclusive disease of the liver. Transfus Apher Sci 27: 3-12, 2002
10. Holler E, Kolb HJ, Hiller E, Mraz W, Lehmacher W, Gleixner B, Seeber C, Jehn U, Gerhartz HH, Brehm G, Willmanns W: Microangiopathy in patients on cyclosporine prophylaxis who developed acute graft-versus-host disease after HLA-identical bone marrow transplantation. Blood 73: 2018-2024, 1989 (Pubitemid 19145140)
11. George JN, Li X, McMinn JR, Terrell DR, Vesely SK, Selby GB: Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome following allogeneic HPC transplantation: A diagnostic dilemma. Transfusion 44: 294-304, 2004 (Pubitemid 38236394)
12. Biedermann BC, Sahner S, Gregor M, Tsakiris DA, Jeanneret C, Pober JS, Gratwohl A: Endothelial injury mediated by cytotoxic t lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet 359: 2078-2083, 2002 (Pubitemid 34680972)
13. Kanamori H, Maruta A, Sasaki S, Yamazaki E, Ueda S, Katoh K, Tamura T, Otsuka-Aoba M, Taguchi J, Harano H, Ogawa K, Mohri H, Okubo T, Matsuzaki M, Watanabe S, Koharazawa H, Fujita H, Kodama F: Diagnostic value of hemostatic parameters in bone marrow transplant-associated thrombotic microangiopathy. Bone Marrow Transplant 21: 705-709, 1998
14. Matsuda Y, Hara J, Osugi Y, Tokimasa S, Fujisaki H, Takai K, Ohta H, Kawa-Ha K, Okada S: Serum levels of soluble adhesion molecules in stem cell transplantation-related complications. Bone Marrow Transplant 27: 977-982, 2001 (Pubitemid 32529880)
15. Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE: VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358: 1129-1136, 2008
16. Min CK, Kim SY, Lee MJ, Eom KS, Kim YJ, Kim HJ, Lee S, Cho SG, Kim DW, Lee JW, Min WS, Kim CC, Cho CS: Vascular endothelial growth factor (VEGF) is associated with reduced severity of acute graft-versus-host disease and nonrelapse mortality after allogeneic stem cell transplantation. Bone Marrow Transplant 38: 149-156, 2006
17. Nash RA, Pepe MS, Storb R, Longton G, Pettinger M, Anasetti C, Appelbaum FR, Bowden RA, Deeg HJ, Doney K, Martin PJ, Sullivan KM, Sanders J, Witherspoon RP: Acute graft-versus-host disease: Analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate. Blood 80: 1838-1845, 1992
18. Randolph SS, Gooley TA, Warren EH, Appelbaum FR, Riddell SR: Female donors contribute to a selective graft-versus- leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants. Blood 103: 347-352, 2004
19. Beddhu S, Samore MH, Roberts MS, Stoddard GJ, Pappas LM, Cheung AK: Creatinine production, nutrition, and glomerular filtration rate estimation. J Am Soc Nephrol 14: 1000-1005, 2003
20. Ross EA, Wilkinson A, Hawkins RA, Danovitch GM: The plasma creatinine concentration is not an accurate reflection of the glomerular filtration rate in stable renal transplant patients receiving cyclosporine. Am J Kidney Dis 10: 113-117, 1987
21. Waiser J, Budde K, Rudolph B, Ortner MA, Neumayer HH: De novo hemolytic uremic syndrome postrenal transplant after cytomegalovirus infection. Am J Kidney Dis 34: 556-559, 1999
22. Tarbell NJ, Guinan EC, Niemeyer C, Mauch P, Sallan SE, Weinstein HJ: Late onset of renal dysfunction in survivors of bone marrow transplantation. Int J Radiat Oncol Biol Phys 15: 99-104, 1988 (Pubitemid 18186422)
23. Antignac C, Gubler MC, Leverger G, Broyer M, Habib R: Delayed renal failure with extensive mesangiolysis following bone marrow transplantation. Kidney Int 35: 1336-1344, 1989 (Pubitemid 19167926)
24. Cohen EP, Lawton CA, Moulder JE: Bone marrow transplant nephropathy: Radiation nephritis revisited. Nephron 70: 217-222, 1995
25. Lawton CA, Cohen EP, Murray KJ, Derus SW, Casper JT, Drobyski WR, Horowitz MM, Moulder JE: Long-term results of selective renal shielding in patients undergoing total body irradiation in preparation for bone marrow transplantation. Bone Marrow Transplant 20: 1069-1074, 1997
26. Yabe H, Hattori K, Inoue H, Matsumoto M, Hamanoue S, Hiroi A, Koike T, Kato S, Shimamura K, Yabe M: Fatal adenovirus infection indistinguishable from thrombotic microangiopathy after allogeneic cd34+ peripheral progenitor cell transplantation. Tokai J Exp Clin Med 30: 71-75, 2005 (Pubitemid 40628375)
27. Bruno B, Zager RA, Boeckh MJ, Gooley TA, Myerson DH, Huang ML, Hackman RC: Adenovirus nephritis in hematopoietic stem-cell transplantation. Transplantation 77: 1049-1057, 2004 (Pubitemid 38508923)
28. Martinez MT, Bucher C, Stussi G, Heim D, Buser A, Tsakiris DA, Tichelli A, Gratwohl A, Passweg JR: Transplant-associated microangiopathy (tam) in recipients of allogeneic hematopoietic stem cell transplants. Bone Marrow Transplant 36: 993-1000, 2005 (Pubitemid 41741563)
29. Pettitt AR, Clark RE: Thrombotic microangiopathy following bone marrow transplantation. Bone Marrow Transplant 14: 495-504, 1994 (Pubitemid 24338473)
30. Schriber JR, Herzig GP: Transplantation-associated thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol 34: 126-133, 1997 (Pubitemid 27175070)
31. Atkinson K, Biggs JC, Hayes J, Ralston M, Dodds AJ, Concannon AJ, Naidoo D: Cyclosporin a associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: Three distinct syndromes. Br J Haematol 54: 59-67, 1983
32. Zeigler ZR, Rosenfeld CS, Andrews DF, 3rd, Nemunaitis J, Raymond JM, Shadduck RK, Kramer RE, Gryn JF, Rintels PB, Besa EC, George JN: Plasma Von Willebrand factor antigen (vwf:Ag) and thrombomodulin (tm) levels in adult thrombotic thrombocytopenic purpura/hemolytic uremic syndromes (ttp/hus) and bone marrow transplant-associated thrombotic microangiopathy (bmt-tm). Am J Hematol 53: 213-220, 1996
33. Chappell ME, Keeling DM, Prentice HG, Sweny P: Haemolytic uraemic syndrome after bone marrow transplantation: An adverse effect of total body irradiation? Bone Marrow Transplant 3: 339-347, 1988 (Pubitemid 18188532)
34. Sarkodee-Adoo C, Sotirescu D, Sensenbrenner L, Rapoport AP, Cottler-Fox M, Tricot G, Ruehle K, Meisenberg B: Thrombotic microangiopathy in blood and marrow transplant patients receiving tacrolimus or cyclosporine a. Transfusion 43: 78-84, 2003 (Pubitemid 36322900)
35. Cutler C, Henry NL, Magee C, Li S, Kim HT, Alyea E, Ho V, Lee SJ, Soiffer R, Antin JH: Sirolimus and thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 11: 551-557, 2005 (Pubitemid 40862452)