-
1
-
-
13544249943
-
Genetic polymorphisms of cytochrome P450 2D6 ( CYP2D6): Clinical consequences, evolutionary aspects and functional diversity
-
Ingelman-Sundberg M: Genetic polymorphisms of cytochrome P450 2D6 ( CYP2D6): clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 5, 6-13 (2005).
-
(2005)
Pharmacogenomics J
, vol.5
, pp. 6-13
-
-
Ingelman-Sundberg, M.1
-
2
-
-
0036124107
-
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
-
Bradford LD: CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3, 229-243 (2002).
-
(2002)
Pharmacogenomics
, vol.3
, pp. 229-243
-
-
Bradford, L.D.1
-
3
-
-
38349132802
-
The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
-
Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS: The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin. Pharmacol. Ther. 83, 234-242 (2008).
-
(2008)
Clin. Pharmacol. Ther
, vol.83
, pp. 234-242
-
-
Gaedigk, A.1
Simon, S.D.2
Pearce, R.E.3
Bradford, L.D.4
Kennedy, M.J.5
Leeder, J.S.6
-
4
-
-
0027534276
-
Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine
-
Bertilsson L, Dahl ML, Sjoqvist F et al.: Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine. Lancet 341, 63 (1993).
-
(1993)
Lancet
, vol.341
, pp. 63
-
-
Bertilsson, L.1
Dahl, M.L.2
Sjoqvist, F.3
-
5
-
-
0027136288
-
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
-
Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjoqvist F, Ingelman-Sundberg M: Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc. Natl Acad. Sci. USA 90, 11825-11829 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 11825-11829
-
-
Johansson, I.1
Lundqvist, E.2
Bertilsson, L.3
Dahl, M.L.4
Sjoqvist, F.5
Ingelman-Sundberg, M.6
-
6
-
-
0035049437
-
Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
-
Siegle I, Fritz P, Eckhardt K, Zanger UM, Eichelbaum M: Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics 11, 237-245 (2001).
-
(2001)
Pharmacogenetics
, vol.11
, pp. 237-245
-
-
Siegle, I.1
Fritz, P.2
Eckhardt, K.3
Zanger, U.M.4
Eichelbaum, M.5
-
7
-
-
4344568973
-
Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: Modulation by endogenous compounds
-
Gervasini G, Carrillo JA, Benitez J: Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds. Clin. Pharmacokinet. 43, 693-706 (2004).
-
(2004)
Clin. Pharmacokinet
, vol.43
, pp. 693-706
-
-
Gervasini, G.1
Carrillo, J.A.2
Benitez, J.3
-
8
-
-
0011578981
-
Debrisoquine hydroxylation polymorphism and personality
-
Bertilsson L, Alm C, De Las Carreras C, Widen J, Edman G, Schalling D: Debrisoquine hydroxylation polymorphism and personality. Lancet 1, 555 (1989).
-
(1989)
Lancet
, vol.1
, pp. 555
-
-
Bertilsson, L.1
Alm, C.2
De Las Carreras, C.3
Widen, J.4
Edman, G.5
Schalling, D.6
-
9
-
-
0027464041
-
Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
-
Llerena. A, Edman G, Cobaleda J, Benitez J, Schalling D, Bertilsson L: Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6. Acta Psychiatr. Scand. 87, 23-28 (1993).
-
(1993)
Acta Psychiatr. Scand
, vol.87
, pp. 23-28
-
-
Llerena, A.1
Edman, G.2
Cobaleda, J.3
Benitez, J.4
Schalling, D.5
Bertilsson, L.6
-
10
-
-
2142642298
-
Association between cytochrome P450 2D6 genotype and harm avoidance
-
Roberts RL, Luty SE, Mulder RT, Joyce PR, Kennedy MA: Association between cytochrome P450 2D6 genotype and harm avoidance. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 127, 90-93 (2004).
-
(2004)
Am. J. Med. Genet. B. Neuropsychiatr. Genet
, vol.127
, pp. 90-93
-
-
Roberts, R.L.1
Luty, S.E.2
Mulder, R.T.3
Joyce, P.R.4
Kennedy, M.A.5
-
11
-
-
2942577455
-
Relationship between Type A and B personality and debrisoquine hydroxylation capacity
-
Gan SH, Ismail R, Wan Adnan WA, Zulmi W, Kumaraswamy N, Larmie ET: Relationship between Type A and B personality and debrisoquine hydroxylation capacity. Br. J. Clin. Pharmacol. 57, 785-789 (2004).
-
(2004)
Br. J. Clin. Pharmacol
, vol.57
, pp. 785-789
-
-
Gan, S.H.1
Ismail, R.2
Wan Adnan, W.A.3
Zulmi, W.4
Kumaraswamy, N.5
Larmie, E.T.6
-
12
-
-
33746923412
-
Association of CYP2D6 genotypes and personality traits in healthy individuals
-
Kirchheiner J, Lang U, Stamm T, Sander T, Gallinat J: Association of CYP2D6 genotypes and personality traits in healthy individuals. J. Clin. Psychopharmacol. 26, 440-442 (2006).
-
(2006)
J. Clin. Psychopharmacol
, vol.26
, pp. 440-442
-
-
Kirchheiner, J.1
Lang, U.2
Stamm, T.3
Sander, T.4
Gallinat, J.5
-
13
-
-
33845911495
-
Could endogenous substrates of drug-metabolizing enzymes influence constitutive physiology and drug target responsiveness?
-
Ozdemir V, Gunes A, Dahl ML, Scordo MG, Williams-Jones B, Someya T: Could endogenous substrates of drug-metabolizing enzymes influence constitutive physiology and drug target responsiveness? Pharmacogenomics 7, 1199-1210 (2006).
-
(2006)
Pharmacogenomics
, vol.7
, pp. 1199-1210
-
-
Ozdemir, V.1
Gunes, A.2
Dahl, M.L.3
Scordo, M.G.4
Williams-Jones, B.5
Someya, T.6
-
14
-
-
0030920945
-
Personality dimensions and depression: Review and commentary
-
Enns MW, Cox BJ: Personality dimensions and depression: review and commentary. Can. J. Psychiatry 42, 274-284 (1997).
-
(1997)
Can. J. Psychiatry
, vol.42
, pp. 274-284
-
-
Enns, M.W.1
Cox, B.J.2
-
15
-
-
0037342251
-
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6
-
Yu AM, Idle JR, Byrd LG, Krausz KW, Kupfer A, Gonzalez FJ: Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. Pharmacogenetics 13, 173-181 (2003).
-
(2003)
Pharmacogenetics
, vol.13
, pp. 173-181
-
-
Yu, A.M.1
Idle, J.R.2
Byrd, L.G.3
Krausz, K.W.4
Kupfer, A.5
Gonzalez, F.J.6
-
16
-
-
22944482153
-
Impact of the CYP2D6 ultra-rapid merabolizer genotype on doxepin pharmacokinetics and serotonin in platelets
-
Kirchheiner J, Henckel HB, Franke I, et al.: Impact of the CYP2D6 ultra-rapid merabolizer genotype on doxepin pharmacokinetics and serotonin in platelets. Pharmacogenet. Genomics 15, 579-587 (2005).
-
(2005)
Pharmacogenet. Genomics
, vol.15
, pp. 579-587
-
-
Kirchheiner, J.1
Henckel, H.B.2
Franke, I.3
-
17
-
-
0031695414
-
Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital
-
de Leon J, Barnhill J, Rogers T, Boyle J, Chou WH, Wedlund PJ: Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital. Am. J. Psychiatry 155, 1278-1280 (1998).
-
(1998)
Am. J. Psychiatry
, vol.155
, pp. 1278-1280
-
-
de Leon, J.1
Barnhill, J.2
Rogers, T.3
Boyle, J.4
Chou, W.H.5
Wedlund, P.J.6
-
18
-
-
2042512985
-
CYP2D6 genotype: Impact on adverse effects and nonresponse during treatment with antidepressants - a pilot study
-
Rau T, Wohlleben G, Wuttke H et al.: CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants - a pilot study. Clin. Pharmacol. Ther. 75, 386-393 (2004).
-
(2004)
Clin. Pharmacol. Ther
, vol.75
, pp. 386-393
-
-
Rau, T.1
Wohlleben, G.2
Wuttke, H.3
-
19
-
-
0025767240
-
Determinants of disease and disability in the elderly: The Rotterdam Elderly Study
-
Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA: Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur. J. Epidemiol. 7, 403-422 (1991).
-
(1991)
Eur. J. Epidemiol
, vol.7
, pp. 403-422
-
-
Hofman, A.1
Grobbee, D.E.2
de Jong, P.T.3
van den Ouweland, F.A.4
-
21
-
-
84965520932
-
The CES-D scale: A self-report depression scale for research in the general population
-
Radloff L: The CES-D scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1, 385-401 (1977).
-
(1977)
Appl. Psychol. Meas
, vol.1
, pp. 385-401
-
-
Radloff, L.1
-
23
-
-
0031718245
-
Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI)
-
Wittchen HU, Lachner G, Wunderlich U, Pfister H: Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI). Soc. Psychiatry Pychiatr. Epidemiol. 33, 568-578 (1998).
-
(1998)
Soc. Psychiatry Pychiatr. Epidemiol
, vol.33
, pp. 568-578
-
-
Wittchen, H.U.1
Lachner, G.2
Wunderlich, U.3
Pfister, H.4
-
24
-
-
40549089935
-
Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants
-
Bijl MJ, Visser LE, Hofman A et al.: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br. J. Clin. Pharmacol. 65, 558-564 (2008).
-
(2008)
Br. J. Clin. Pharmacol
, vol.65
, pp. 558-564
-
-
Bijl, M.J.1
Visser, L.E.2
Hofman, A.3
-
25
-
-
3042515935
-
Polymorphic cytochrome P450 2D6: Humanized mouse model and endogenous substrates
-
Yu AM, Idle JR, Gonzalez FJ: Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab. Rev. 36, 243-277 (2004).
-
(2004)
Drug Metab. Rev
, vol.36
, pp. 243-277
-
-
Yu, A.M.1
Idle, J.R.2
Gonzalez, F.J.3
|