메뉴 건너뛰기




Volumn 8, Issue 5, 2009, Pages 1045-1054

Epigenetic reversal of acquired resistance to 5-fluorouracil treatment

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; FLUOROURACIL; FLUOROURIDINE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE KINASE;

EID: 66849111560     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0717     Document Type: Conference Paper
Times cited : (26)

References (45)
  • 1
    • 0029001154 scopus 로고
    • Suppression of intestinal neoplasia by DNA hypomethylation
    • Laird PW, Jackson-Grusby L, Fazeli A, et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995;81:197-205.
    • (1995) Cell , vol.81 , pp. 197-205
    • Laird, P.W.1    Jackson-Grusby, L.2    Fazeli, A.3
  • 2
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-428 (Pubitemid 34587077)
    • (2002) Nature Reviews Genetics , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 4
    • 5444255150 scopus 로고    scopus 로고
    • The epigenetics of cancer etiology
    • DOI 10.1016/j.semcancer.2004.06.005, PII S1044579X04000483
    • Feinberg AP. The epigenetics of cancer etiology. Semin Cancer Biol 2004;14:427-432 (Pubitemid 39360990)
    • (2004) Seminars in Cancer Biology , vol.14 , Issue.6 , pp. 427-432
    • Feinberg, A.P.1
  • 6
    • 0345357773 scopus 로고    scopus 로고
    • Gene Silencing in Cancer in Association with Promoter Hypermethylation
    • DOI 10.1056/NEJMra023075
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-2054 (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 7
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • DOI 10.1101/gad.947102
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6-21. (Pubitemid 34049633)
    • (2002) Genes and Development , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 8
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - A mechanism for early oncogenic pathway addiction?
    • Baylin SB, Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 2006;6:107-116
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 11
    • 3042693554 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia
    • DOI 10.1038/labinvest.3700108
    • Lee S, Hwang KS, Lee HJ, Kim JS, Kang GH. Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. Lab Invest 2004;84:884-893 (Pubitemid 38833248)
    • (2004) Laboratory Investigation , vol.84 , Issue.7 , pp. 884-893
    • Lee, S.1    Hwang, K.S.2    Lee, H.J.3    Kim, J.-S.4    Kang, G.H.5
  • 12
    • 16544389958 scopus 로고    scopus 로고
    • Promoter Methylation Inhibits APC Gene Expression by Causing Changes in Chromatin Conformation and Interfering with the Binding of Transcription Factor CCAAT-Binding Factor
    • DOI 10.1158/0008-5472.CAN-03-3000
    • Deng G, Song GA, Pong E, Sleisenger M, Kim YS. Promoter methylation inhibits APC gene expression by causing changes in chromatin conformation and interfering with the binding of transcription factor CCAAT-binding factor. Cancer Res 2004;64:2692-2698 (Pubitemid 38500603)
    • (2004) Cancer Research , vol.64 , Issue.8 , pp. 2692-2698
    • Deng, G.1    Song, G.-A.2    Pong, E.3    Sleisenger, M.4    Kim, Y.S.5
  • 14
    • 0037869289 scopus 로고    scopus 로고
    • Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines
    • DOI 10.1002/ijc.11176
    • Arnold CN, Goel A, Boland CR. Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer 2003;106:66-73. (Pubitemid 36750389)
    • (2003) International Journal of Cancer , vol.106 , Issue.1 , pp. 66-73
    • Arnold, C.N.1    Goel, A.2    Boland, C.R.3
  • 15
    • 0035950541 scopus 로고    scopus 로고
    • Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression
    • DOI 10.1038/sj.onc.1204891
    • Deng G, Chen A, Pong E, Kim YS. Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression. Oncogene 2001;20:7120-7127 (Pubitemid 33052206)
    • (2001) Oncogene , vol.20 , Issue.48 , pp. 7120-7127
    • Deng, G.1    Chen, A.2    Pong, E.3    Kim, Y.S.4
  • 16
    • 0032820505 scopus 로고    scopus 로고
    • 0 stage colorectal cancers: Association with DNA replication error and shorter survival
    • 0 stage colorectal cancers: association with DNA replication error and shorter survival. Oncology 1999;57:149-156
    • (1999) Oncology , vol.57 , pp. 149-156
    • Liang, J.T.1    Chang, K.J.2    Chen, J.C.3
  • 17
    • 37549066863 scopus 로고    scopus 로고
    • Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells
    • Jacinto FV, Ballestar E, Ropero S, Esteller M. Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. Cancer Res 2007;67:11481-11486
    • (2007) Cancer Res , vol.67 , pp. 11481-11486
    • Jacinto, F.V.1    Ballestar, E.2    Ropero, S.3    Esteller, M.4
  • 18
    • 33646128506 scopus 로고    scopus 로고
    • Epigenetics as a mechanism driving polygenic clinical drug resistance
    • Glasspool RM, Teodoridis JM, Brown R. Epigenetics as a mechanism driving polygenic clinical drug resistance. Br J Cancer 2006;94:1087-1092
    • (2006) Br J Cancer , vol.94 , pp. 1087-1092
    • Glasspool, R.M.1    Teodoridis, J.M.2    Brown, R.3
  • 19
    • 0345701519 scopus 로고    scopus 로고
    • Aberrant DNA methylation in ovarian cancer: Is there an epigenetic predisposition to drug response?
    • Wei SH, Brown R, Huang TH. Aberrant DNA methylation in ovarian cancer: is there an epigenetic predisposition to drug response? Ann N Y Acad Sci 2003;983:243-250
    • (2003) Ann N Y Acad Sci , vol.983 , pp. 243-250
    • Wei, S.H.1    Brown, R.2    Huang, T.H.3
  • 21
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- Or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • DOI 10.1038/sj.onc.1204750
    • Fulda S, Kufer MU, Meyer E, van Valen F, Dockhorn-Dworniczak B, Debatin KM. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001;20:5865-5877 (Pubitemid 32937956)
    • (2001) Oncogene , vol.20 , Issue.41 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    Van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.-M.6
  • 23
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients
    • DOI 10.1158/1078-0432.CCR-03-0732
    • Gifford G, Paul J, Vasey PA, Kaye SB, Brown R. The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res 2004;10:4420-4426 (Pubitemid 38878884)
    • (2004) Clinical Cancer Research , vol.10 , Issue.13 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3    Kaye, S.B.4    Brown, R.5
  • 24
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
    • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006;106:1794-1803
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 26
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R. Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 2000;60:6039-6044
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 28
    • 0026637845 scopus 로고
    • Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
    • Aschele C, Sobrero A, Faderan MA, Bertino JR. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 1992;52:1855-1864.
    • (1992) Cancer Res , vol.52 , pp. 1855-1864
    • Aschele, C.1    Sobrero, A.2    Faderan, M.A.3    Bertino, J.R.4
  • 29
    • 0028797769 scopus 로고
    • Effect of clinically modeled regimens on the growth response and development of resist ance in human colon carcinoma cell lines
    • Pizzorno G, Handschumacher RE. Effect of clinically modeled regimens on the growth response and development of resist ance in human colon carcinoma cell lines. Biochem Pharmacol 1995;49:559-565
    • (1995) Biochem Pharmacol , vol.49 , pp. 559-565
    • Pizzorno, G.1    Handschumacher, R.E.2
  • 30
    • 0035710746 scopus 로고    scopus 로고
    • -DD;CT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-DDC(T)) method. Methods 2001;25:402-408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 0346564424 scopus 로고    scopus 로고
    • Real-time RT-PCR analysis of mRNA decay: Half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines
    • DOI 10.1186/1475-2867-2-1
    • Leclerc GJ, Leclerc GM, Barredo JC. Real-time RT-PCR analysis of mRNA decay: half-life of β-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines. Cancer Cell Int 2002;2:1. (Pubitemid 38751051)
    • (2002) Cancer Cell International , vol.2 , pp. 1
    • Leclerc, G.J.1    Leclerc, G.M.2    Barredo, J.C.3
  • 33
    • 0034201441 scopus 로고    scopus 로고
    • EMBOSS: The European Molecular Biology Open Software Suite
    • Rice P, Longden I, Bleasby A. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet 2000;16:276-277
    • (2000) Trends Genet , vol.16 , pp. 276-277
    • Rice, P.1    Longden, I.2    Bleasby, A.3
  • 34
    • 21844463806 scopus 로고    scopus 로고
    • Decitabine dosing schedules
    • DOI 10.1053/j.seminhematol.2005.05.006, PII S0037196305000661, Emerging Role of Epigenetic Therapy: Focus on Decitabine
    • Kantarjian HM, Issa JP. Decitabine dosing schedules. Semin Hematol 2005;42:S17-22. (Pubitemid 40961868)
    • (2005) Seminars in Hematology , vol.42 , Issue.SUPPL. 2
    • Kantarjian, H.M.1    Issa, J.-P.J.2
  • 35
    • 0016786638 scopus 로고
    • The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine
    • Wilkinson DS, Tlsty TD, Hanas RJ. The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine. Cancer Res 1975;35:3014-3020
    • (1975) Cancer Res , vol.35 , pp. 3014-3020
    • Wilkinson, D.S.1    Tlsty, T.D.2    Hanas, R.J.3
  • 36
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • DOI 10.1038/nrc1074
    • Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-338 (Pubitemid 37328853)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.5 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 38
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio RB, Harris BE. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 1989;16:215-237 (Pubitemid 19114713)
    • (1989) Clinical Pharmacokinetics , vol.16 , Issue.4 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 39
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer - A tale of two drugs: Implications for biochemical modulation
    • Sobrero AF, Aschele C, Bertino JR. Fluorouracil in colorectal cancer- a tale of two drugs: implications for biochemical modulation. J Clin Oncol 1997;15:368-381 (Pubitemid 27020595)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.1 , pp. 368-381
    • Sobrero, A.F.1    Aschele, C.2    Bertino, J.R.3
  • 40
    • 10044286102 scopus 로고    scopus 로고
    • 5-Fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs
    • DOI 10.1128/MCB.24.24.10766-10776.2004
    • Fang F, Hoskins J, Butler JS. 5-Fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs. Mol Cell Biol 2004;24:10766-10776 (Pubitemid 39603133)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.24 , pp. 10766-10776
    • Fang, F.1    Hoskins, J.2    Butler, J.S.3
  • 42
    • 34047137913 scopus 로고    scopus 로고
    • Transcriptional reactivation of murine cytomegalovirus ie gene expression by 5-aza-2′-deoxycytidine and trichostatin a in latently infected cells despite lack of methylation of the major immediate-early promoter
    • DOI 10.1099/vir.0.82696-0
    • Hummel M, Yan S, Li Z, Varghese TK, Abecassis M. Transcriptional reactivation of murine cytomegalovirus in gene expression by 5-aza-2′- deoxycytidine and trichostatin A in latently infected cells despite lack of methylation of the major immediate-early promoter. J Gen Virol 2007;88:1097-1102 (Pubitemid 46523497)
    • (2007) Journal of General Virology , vol.88 , Issue.4 , pp. 1097-1102
    • Hummel, M.1    Yan, S.2    Li, Z.3    Varghese, T.K.4    Abecassis, M.5
  • 43
    • 33744932953 scopus 로고    scopus 로고
    • Identification of novel target genes by an epigenetic reactivation screen of renal cancer
    • DOI 10.1158/0008-5472.CAN-05-3365
    • Ibanez de Caceres I, Dulaimi E, Hoffman AM, Al-Saleem T, Uzzo RG, Cairns P. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Cancer Res 2006;66:5021-5028 (Pubitemid 43844922)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5021-5028
    • Ibanez De Caceres, I.1    Dulaimi, E.2    Hoffman, A.M.3    Al-Saleem, T.4    Uzzo, R.G.5    Cairns, P.6
  • 44
    • 0033598843 scopus 로고    scopus 로고
    • Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells
    • Karpf A R, Peterson PW, Rawlins JT, et al. Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells. Proc Natl Acad Sci U S A 1999;96:14007-14012
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14007-14012
    • Karpf, A.R.1    Peterson, P.W.2    Rawlins, J.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.