Phenotypic cure 6 years after bone marrow transplantation in a β-thalassemia patient

American Journal of Hematology

Volumn 84, Issue 6, 2009, Pages 373-375

  Berger Achituv, Sivan ^a   Rothschild, Michal ^a   Naparstek, Elizabeth ^b,c   Wolach, Baruch ^a,c  

^a MEIR MEDICAL CENTER   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; BETA GLOBIN; BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DEFEROXAMINE; DEFEROXAMINE MESYLATE; GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN; IMMUNOGLOBULIN; STEROID; TRANEXAMIC ACID;

ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; BONE MARROW TRANSPLANTATION; CASE REPORT; CHIMERA; CLINICAL EVALUATION; GENE MUTATION; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON CHELATION; MALE; MUTATIONAL ANALYSIS; NEUTROPENIA; PHENOTYPE; PRIORITY JOURNAL; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADOLESCENT; BETA-THALASSEMIA; BONE MARROW TRANSPLANTATION; CHILD, PRESCHOOL; HUMANS; MALE;

EID: 66849089903     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21404     Document Type: Article

References (19)

1. Di Bartolomeo P, Santarone S, Di Bartolomeo E, et al. Long-term results of survival in patients with thalassemia major treated with bone marrow transplantation. Am J Hematol 2008;83:528-530.
2. Andreani M, Nesci S, Lucarelli G, et al. Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation. Bone Marrow Transplant 2000;25:401-404.
3. Andreani M, Manna M, Lucarelli G, et al. Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia. Blood 1996;87:3494-3499.
4. Kapelushnik J, Or R, Filon D, et al. Analysis of beta-globin mutations shows stable mixed chimerism in patients with thalassemia after bone marrow transplantation. Blood 1995;86:3241-13216
5. Baron F, Sandmaier BM. Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning. Leukemia 2006;20:1690-1700.
6. Lisini D, Zecca M, Giorgiani G, et al. Donor/recipient mixed chimerism does not predict graft failure in children with beta-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling. Haematologica 2008;93: 1859-1867.
7. Manna M, Nesci S, Andreani M, et al. Influence of the conditioning regimens on the incidence of mixed chimerism in thalassemic transplanted patients. Bone Marrow Transplant 1993;12(Suppl 1):70-73.
8. Khan F, Agarwal A, Agrawal S. Significance of chimerism in hematopoietic stem cell transplantation: New variations on an old theme. Bone Marrow Transplant 2004;34:1-12.
9. Ugozzoli L, Yam P, Petz LD, et al. Amplification by the polymerase chain reaction of hypervariable regions of the human genome for evaluation of chimerism after bone marrow transplantation. Blood 1991;77:1607-1615.
10. Alizadeh M, Bernard M, Danic B, et al. Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction. Blood 2002;99:4618-4625.
11. Schouten HC, Sizoo W, van't Veer MB, et al. Incomplete chimerism in erythroid, myeloid and B lymphocyte lineage after T cell-depleted allogeneic bone marrow transplantation. Bone Marrow Transplant 1988;3: 407-412.
12. Thiele J, Wickenhauser C, Kvasnicka HM, et al. Mixed chimerism of erythro- and megakaryopoiesis following allogeneic bone marrow transplantation. Acta Haematol 2003;109:176-183.
13. Thiele J, Varus E, Siebolts U, et al. Dualism of mixed chimerism between hematopoiesis and stroma in chronic idiopathic myelofibrosis after allogeneic stem cell transplantation. Histol Histopathol 2007;22:365-372.
14. Wu CJ, Hochberg EP, Rogers SA, et al. Molecular assessment of erythroid lineage chimerism following nonmyeloablative allogeneic stem cell transplantation. Exp Hematol 2003;31:924-933.
15. 0-thalassaemia bone marrow transplant recipient with red cell indices indicative of apparent full engraftment. Br J Haematol 1997;99:61-63.
16. Bär BM, Schattenberg A, Van Dijk BA, et al. Host and donor erythrocyte repopulation patterns after allogeneic bone marrow transplantation analysed with antibody-coated fluorescent microspheres. Br J Haematol 1989;72:239-245.
17. First LR, Smith BR, Lipton J, et al. Isolated thrombocytopenia after allogeneic bone marrow transplantation: Existence of transient and chronic thrombocytopenic syndromes. Blood 1985;65:368-374.
18. Mital MK, Curtis A, Spencer V, et al. Delayed engraftment and mixed chimerism after HLA-identical sibling donor BMT in Fanconi anaemia. Bone Marrow Transplant 1999;24:201-204.
19. Giardini C, Visani G, Lucesole M, et al. Unusual late rejection of the first graft seven years after allogeneic transplant for thalassemia successfully treated with second BMT. Bone Marrow Transplant 2007;39(Suppl 1):S191.