Inspiratory duty cycle responses to flow limitation predict nocturnal hypoventilation

European Respiratory Journal

Volumn 33, Issue 5, 2009, Pages 1068-1076

  Schneider, H ^a,b   Krishnan, V ^a   Pichard, L E ^a   Patil, S P ^a   Smith, P L ^a   Schwartz, A R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Nocturnal hypoventilation; Obstructive sleep apnoea; Sex; Sleep disordered breathing; Susceptibility; Ventilatory control

Indexed keywords

ADULT; AIRWAY OBSTRUCTION; ARTICLE; BREATHING PATTERN; BREATHING RATE; CONTROLLED STUDY; FEMALE; HUMAN; HYPOVENTILATION; INSPIRATORY CAPACITY; INSPIRATORY DUTY CYCLE; LUNG MINUTE VOLUME; LUNG VENTILATION; MALE; NONREM SLEEP; NOSE AIRWAY RESISTANCE; PRIORITY JOURNAL; SEX DIFFERENCE; SLEEP APNEA SYNDROME; UPPER RESPIRATORY TRACT OBSTRUCTION;

ADULT; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANTHROPOMETRY; CIRCADIAN RHYTHM; FEMALE; HUMANS; HYPOVENTILATION; INSPIRATORY CAPACITY; MALE; PREDICTIVE VALUE OF TESTS; RESPIRATORY FUNCTION TESTS; RESPIRATORY MECHANICS; SLEEP; SLEEP APNEA, OBSTRUCTIVE; WAKEFULNESS;

EID: 66749182796     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00063008     Document Type: Article

References (45)

1. Gleadhill IC, Schwartz AR, Schubert N, Wise RA, Permutt S, Smith PL. Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Am Rev Respir Dis 1991; 143: 1300-1303.
2. Gold AR, Marcus CL, Dipalo F, Gold MS. Upper airway collapsibility during sleep in upper airway resistance syndrome. Chest 2002; 121: 1531-1540.
3. Schwartz AR, Smith PL, Wise RA, Bankman I, Permutt S. Effect of positive nasal pressure on upper airway pressure- flow relationships. J Appl Physiol 1989; 66: 1626-1634.
4. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002; 165: 1217-1239.
5. Jordan AS, McEvoy RD. Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms. Sleep Med Rev 2003; 7: 377-389.
6. Redline S, Kump K, Tishler PV, Browner I, Ferrette V. Gender differences in sleep-disordered breathing in a community-based sample. Am J Respir Crit Care Med 1994;149: 722-726.
7. Guilleminault C, Partinen M, Hollman K, Powell N, Stoohs R. Familial aggregates in obstructive sleep apnea syndrome. Chest 1995; 107: 1545-1551.
8. Schwab RJ. Genetic determinants of upper airway structure that predispose to obstructive sleep apnea. Respir Physiol Neurobiol 2005; 147: 289-298.
9. Schwab RJ, Pasirstein M, Kaplan L, et al. Family aggregation of upper airway soft tissue structures in normal subjects and patients with sleep apnea. Am J Respir Crit Care Med 2006; 173: 453-463.
10. 10Redline S, Tishler PV. Familial influences on sleep apnea. In: Saunders NA, Sullivan CE, eds. Sleep and Breathing. 2nd Edn. New York, Marcel Dekker Inc., 1994; pp. 363-377.
11. Patel SR. Shared genetic risk factors for obstructive sleep apnea and obesity. J Appl Physiol 2005; 99: 1600-1606.
12. Palmer LJ, Buxbaum SG, Larkin EK, et al. Whole genome scan for obstructive sleep apnea and obesity in African- American families. Am J Respir Crit Care Med 2004; 169:1314-1321.
13. Redline S, Tishler PV, Tosteson TD, et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995; 151: 682-687.
14. King ED, O'Donnell CP, Smith PL, Schwartz AR. A model of obstructive sleep apnea in normal humans. Role of the upper airway. Am J Respir Crit Care Med 2000; 161:1979-1984.
15. Patil SP, Schneider H, Marx JJ, Gladmon E, Schwartz AR, Smith PL. Neuromechanical control of upper airway patency during sleep. J Appl Physiol 2007; 102: 547-556.
16. Jordan AS, Wellman A, Heinzer RC, et al. Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans. Thorax 2007; 62: 861-867.
17. Schneider H, Patil SP, Canisius S, et al. Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5. J Appl Physiol 2003; 95: 11-19.
18. Younes M. Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea. Am J Respir Crit Care Med 2003; 168: 645-658.
19. Stoohs R, Guilleminault C. Snoring during NREM sleep: respiratory timing, esophageal pressure and EEG arousal. Respir Physiol 1991; 85: 151-167.
20. Tagaito Y, Schneider H, O'Donnell CP, Smith PL, Schwartz AR. Ventilating with tracheal gas insufflation and periodic tracheal occlusion during sleep and wakeful-ness. Chest 2002; 122: 1742-1750.
21. Pichard LE, Patil SP, Gladmon E, Smith PL, Schwartz AR, Schneider H. Women have a greater ventilatory responses to upper airway obstruction than men. ConfProc IEEE Eng Med Biol Soc 2004; 5: 3878-3880.
22. Krishnan V, Pichard LE, Patil S, Schwartz AR, Smith PL, Schneider H. Gender differences in ventilatory response to inspiratory flow limitation during non rapid eye movement (NREM) sleep. American Thoracic Society 2007; 3: A197.
23. Smith PL, Wise RA, Gold AR, Schwartz AR, Permutt S. Upper airway pressure-flow relationships in obstructive sleep apnea. J Appl Physiol 1988; 64: 789-795.
24. Smith PL, Schwartz AR, Gauda E, Wise R, Brower R, Permutt S. The modulation of upper airway critical pressures during sleep. In: Issa FG, Surratt PM, Remmers JE, eds. Sleep and Respiration. New York, Wiley-Liss, 1990; pp. 253-260.
25. Eastwood PR, Szollosi I, Platt PR, Hillman DR. Collapsibility of the upper airway during anesthesia with isoflurane. Anesthesiology 2002; 97: 786-793.
26. Patil SP, Punjabi NM, Schneider H, O'Donnell CP, Smith PL, Schwartz AR. A simplified method for measuring critical pressures during sleep in the clinical setting. Am J Respir Crit Care Med 2004; 170: 86-93.
27. Miller MR, Crapo R, Hankinson J, et al. General considerations for lung function testing. Eur Respir J 2005; 26: 153-161.
28. Chow CM, Xi L, Smith CA, Saupe KW, Dempsey JA. A volume-dependent apneic threshold during NREM sleep in the dog. J Appl Physiol 1994; 76: 2315-2325.
29. Coleridge HM, Coleridge JCG. Reflexes evoked from tracheobronchial tree and lungs. In: Fishman AP, Cherniack NS, Widdicombe JG, Geiger SR, eds. Handbook of Physiology. Section 3: The Respiratory System. Volume II Control of Breathing, Part 1.Baltimore, Waverly Press Inc., 1986; pp. 395-429.
30. Iber C, Simon P, Skatrud JB, Mahowald MW, Dempsey JA. The Breuer-Hering reflex in humans. Effects of pulmonary denervation and hypocapnia. Am J Respir Crit Care Med 1995; 152: 217-224.
31. Kimoff RJ, Sforza E, Champagne V, Ofiara L, Gendron D. Upper airway sensation in snoring and obstructive sleep apnea. Am J Respir Crit Care Med 2001; 164: 250-255.
32. Leevers AM, Simon PM, Xi L, Dempsey JA. Apnoea following normocapnic mechanical ventilation in awake mammals: a emonstration of control system inertia. J Physiol (Lond) 1993; 472: 749-768.
33. Manchanda S, Leevers AM, Wilson CR, Simon PM, Skatrud JB, Dempsey JA. Frequency and volume thresholds for inhibition of inspiratory motor output during mechanical ventilation. Respir Physiol 1996; 105: 1-16.
34. Aitken ML, Franklin JL, Pierson DJ, Schoene RB. Influence of body size and gender on control of ventilation. J Appl Physiol 1986; 60: 1894-1899.
35. White DP, Weil JV, Zwillich CW. Metabolic rate and breathing during sleep. J Appl Physiol 1985; 59: 384-391.
36. Fontvieille AM, Rising R, Spraul M, Larson DE, Ravussin E. Relationship between sleep stages and metabolic rate in humans. Am J Physiol 1994; 267: E732-E737.
37. Webb P, Hiestand M. Sleep metabolism and age. J Appl Physiol 1975; 38: 257-262.
38. Ferraro R, Lillioja S, Fontvieille AM, Rising R, Bogardus C, Ravussin E. Lower sedentary metabolic rate in women compared with men. J Clin Invest 1992; 90: 780-784.
39. Kreider MB, Biskirk ER, Bass DE. Oxygen consumption and body temperatures during the night. J Appl Physiol 1958; 12: 361-366.
40. Schneider H, Boudewyns A, Smith PL, et al. Modulation of upper airway collapsibility during sleep: influence of respiratory phase and flow regimen. J Appl Physiol 2002;93: 1365-1376.
41. Schwartz AR, O'Donnell CP, Baron J, et al. The hypotonic upper airway in obstructive sleep apnea: role of structures and neuromuscular activity. Am J Respir Crit Care Med 1998; 157: 1051-1057.
42. Kars AH, Bogaard JM, Stijnen T, de Vries J, Verbraak AF, Hilvering C. Dead space and slope indices from the expiratory carbon dioxide tension-volume curve. Eur Respir J 1997; 10: 1829-1836.
43. 2. J Clin Invest 1948; 27: 327-334.
44. Milic-Emili J, Zin WA. Breathing responses to imposed mechanical loads. In: Fishman AP, Cherniack NS, Widdicombe JG, Geiger SR, eds. Handbook of Physiology. Section 3 - The Respiratory System, Vol. II. Bethesda, American Physiological Society, 1986; pp. 751-769.
45. Iber C, Berssenbrugge A, Skatrud JB, Dempsey JA. Ventilatory adaptations to resistive loading during wake- fulness and on-REM sleep. J Appl Physiol 1982; 52: 607-614.