Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21

Carcinogenesis

Volumn 30, Issue 6, 2009, Pages 1041-1048

  Derks, Sarah ^b   Bosch, Linda J W ^a   Niessen, Hanneke E C ^b   Moerkerk, Peter T M ^b   van den Bosch, Sandra M ^b   Carvalho, Beatriz ^a   Mongera, Sandra ^a   Voncken, J Willem ^b   Meijer, Gerrit A ^a   de Bruïne, Adriaan P ^b   Herman, James G ^b,c   van Engeland, Manon ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CPG BINDING PROTEIN CXXC1; HISTONE 3 TRIMETHYL LYSINE 27; HISTONE 3 TRIMETHYL LYSINE 9; HISTONE H3; METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 1; METHYL CPG BINDING PROTEIN 2; SMAD4 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CHROMOSOME 18Q; CHROMOSOME DELETION; CHROMOSOME LOSS; COLON CANCER; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; CPG ISLAND; EPIGENETICS; FEMALE; GENE AMPLIFICATION; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION;

AZACITIDINE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 18; COLONIC NEOPLASMS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONES; HUMANS; HYDROXAMIC ACIDS; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS, GENETIC; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS;

EID: 66749172219     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp073     Document Type: Article

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